Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

Autor: Christel F. A. Ramirez, Daniel Taranto, Masami Ando-Kuri, Marnix H. P. de Groot, Efi Tsouri, Zhijie Huang, Daniel de Groot, Roelof J. C. Kluin, Daan J. Kloosterman, Joanne Verheij, Jing Xu, Serena Vegna, Leila Akkari

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)

Abstract Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis. Yet several aspects underlying their dynamic alter

Externí odkaz: https://doaj.org/article/8fdb0db866fb4b6fba788951b3b0d68b

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

Autor: Roelof J. C. Kluin, Kristel Kemper, Thomas Kuilman, Julian R. de Ruiter, Vivek Iyer, Josep V. Forment, Paulien Cornelissen-Steijger, Iris de Rink, Petra ter Brugge, Ji-Ying Song, Sjoerd Klarenbeek, Ultan McDermott, Jos Jonkers, Arno Velds, David J. Adams, Daniel S. Peeper, Oscar Krijgsman

Publikováno v: BMC Bioinformatics, Vol 19, Iss 1, Pp 1-15 (2018)

Abstract Background Mouse xenografts from (patient-derived) tumors (PDX) or tumor cell lines are widely used as models to study various biological and preclinical aspects of cancer. However, analyses of their RNA and DNA profiles are challenging, bec

Externí odkaz: https://doaj.org/article/6434550c4ed14fcc9809b0f01e508946

Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.

Autor: David M Vossen, Caroline V M Verhagen, Reidar Grénman, Roelof J C Kluin, Marcel Verheij, Michiel W M van den Brekel, Lodewyk F A Wessels, Conchita Vens

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206632 (2018)

BACKGROUND:Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA

Externí odkaz: https://doaj.org/article/1ece493379cf446194cdc3f9516511b8

Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation

Autor: Cormac, Murphy, Elisabeth, Naderlinger, Amber, Mater, Roelof J C, Kluin, Anja, Wilmes

Publikováno v: Murphy, C, Naderlinger, E, Mater, A, Kluin, R J C & Wilmes, A 2023, ' Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation ', ALTEX, vol. 40, no. 1, pp. 141-159 . https://doi.org/10.14573/altex.2112204
ALTEX, 40(1), 141-159. Spektrum, Akad. Verl., Springer Science + Business

Human induced pluripotent stem cells (hiPSCs) offer great opportunities within the 3R framework. In the field of toxicology, they may contribute greatly to the reduction and eventually replacement of animal models. However, culturing hiPSCs as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b298c1ac63a9fb7425598677f2611b39
https://doi.org/10.14573/altex.2112204

Dynamic changes in clonal architecture during disease progression in follicular lymphoma

Autor: Christoffer Flensburg, Tobias Sargeant, Astrid Bosma, Roelof J. C. Kluin, Robby E. Kibbelaar, Mels Hoogendoorn, Warren S. Alexander, Andrew W. Roberts, René Bernards, Daphne de Jong, Ian J. Majewski

Follicular lymphoma (FL) is typically a slow growing cancer that can be effectively treated. Some patients undergo transformation to diffuse large B cell lymphoma (DLBCL), which is frequently resistant to chemotherapy and is generally fatal. Targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5d18ae3bd0cfac5b735f54bc523284
https://doi.org/10.1101/181792