Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Roelof A. J. Smit"'
Autor:
Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Genome-wide association studies have identified over five hundred loci that contribute to variation in type 2 diabetes (T2D), an established risk factor for many diseases. However, the mechanisms and extent through which these loci contribut
Externí odkaz:
https://doaj.org/article/842d0f1aec394ab0a493c4db4ae0d3be
Autor:
Nuzulul Kurniansyah, Matthew O. Goodman, Tanika N. Kelly, Tali Elfassy, Kerri L. Wiggins, Joshua C. Bis, Xiuqing Guo, Walter Palmas, Kent D. Taylor, Henry J. Lin, Jeffrey Haessler, Yan Gao, Daichi Shimbo, Jennifer A. Smith, Bing Yu, Elena V. Feofanova, Roelof A. J. Smit, Zhe Wang, Shih-Jen Hwang, Simin Liu, Sylvia Wassertheil-Smoller, JoAnn E. Manson, Donald M. Lloyd-Jones, Stephen S. Rich, Ruth J. F. Loos, Susan Redline, Adolfo Correa, Charles Kooperberg, Myriam Fornage, Robert C. Kaplan, Bruce M. Psaty, Jerome I. Rotter, Donna K. Arnett, Alanna C. Morrison, Nora Franceschini, Daniel Levy, the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated w
Externí odkaz:
https://doaj.org/article/1a3f2850a7bb43a88a01df6eb8a52c37
Autor:
Stella Trompet, Iris Postmus, Helen R. Warren, Raymond Noordam, Roelof A. J. Smit, Elizabeth Theusch, Xiaohui Li, Benoit Arsenault, Daniel I. Chasman, Graham A. Hitman, Patricia B. Munroe, Jerome I. Rotter, Bruce M. Psaty, Mark J. Caulfield, Ron M. Krauss, Adrienne L. Cupples, Wouter J. Jukema
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Background: The pharmacogenetic effect on cardiovascular disease reduction in response to statin treatment has only been assessed in small studies. In a pharmacogenetic genome wide association study (GWAS) analysis within the Genomic Investigation of
Externí odkaz:
https://doaj.org/article/a2d8d3a7c59940099b7735739ad32258
Autor:
Ian J. Neeland, Sebastiaan C. Boone, Dennis O. Mook‐Kanamori, Colby Ayers, Roelof A. J. Smit, Ioanna Tzoulaki, Ibrahim Karaman, Claire Boulange, Dhananjay Vaidya, Naresh Punjabi, Matthew Allison, David M. Herrington, J. Wouter Jukema, Frits R. Rosendaal, Hildo J. Lamb, Ko Willems van Dijk, Philip Greenland, Renée de Mutsert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)
Background Identifying associations between serum metabolites and visceral adipose tissue (VAT) could provide novel biomarkers of VAT and insights into the pathogenesis of obesity‐related diseases. We aimed to discover and replicate metabolites ref
Externí odkaz:
https://doaj.org/article/502ded21db1845dd93d04118598e9bd8
Autor:
Lauren A. Stalbow, Michael H. Preuss, Roelof A. J. Smit, Nathalie Chami, Lise Bjørkhaug, Ingvild Aukrust, Anna L. Gloyn, Ruth J. F. Loos
Publikováno v:
Diabetologia
Stalbow, L A, Preuss, M H, Smit, R A J, Chami, N, Bjørkhaug, L, Aukrust, I, Gloyn, A L & Loos, R J F 2023, ' The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations ', Diabetologia, vol. 66, pp. 116-126 . https://doi.org/10.1007/s00125-022-05806-2
Stalbow, L A, Preuss, M H, Smit, R A J, Chami, N, Bjørkhaug, L, Aukrust, I, Gloyn, A L & Loos, R J F 2023, ' The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations ', Diabetologia, vol. 66, pp. 116-126 . https://doi.org/10.1007/s00125-022-05806-2
Aims/hypothesis We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups. Methods Using exome se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a804f0062bcda997dd44bc0621f49e
https://hdl.handle.net/11250/3044350
https://hdl.handle.net/11250/3044350
Autor:
Lauren A, Stalbow, Michael H, Preuss, Roelof A J, Smit, Nathalie, Chami, Lise, Bjørkhaug, Ingvild, Aukrust, Anna L, Gloyn, Ruth J F, Loos
Publikováno v:
Diabetologia. 66(1)
We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups.Using exome sequencing data of 160,615
Autor:
Raymond, Noordam, Kristi, Läll, Roelof A J, Smit, Triin, Laisk, Andres, Metspalu, Tõnu, Esko, Lili, Milani, Ruth J F, Loos, Reedik, Mägi, Ko, Willems van Dijk, Diana, van Heemst
Publikováno v:
Diabetes, 70(8), 1816-1825. AMER DIABETES ASSOC
The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we used a stratification based on age of diagnosis to gain insight into the genetics and causal risk factors of T2D across different age-groups. We performed genome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3313fd16f482d2aca989bf038bf32b0e
http://hdl.handle.net/1887/3276822
http://hdl.handle.net/1887/3276822