Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Roelf Datema"'
Publikováno v:
European Journal of Biochemistry. 130:147-153
Mucosa from the duodenal and jejunal regions of pig small intestine was repeatedly freeze-thaw treated to solubilize an enzyme preparation, enriched in maltase, glucoamylase and alpha-limit dextrinase activities; isomaltase and sucrase remained essen
Publikováno v:
Pharmacology & Therapeutics
Publikováno v:
Journal of General Virology. 72:1959-1965
We have described two types of oligosaccharide modification influencing the antigenicity of the herpes simplex virus type 1 (HSV-1)-specified glycoprotein C (gC-1). First, the expression of several epitopes belonging to antigenic site II of gC-1 is d
Autor:
Erik Lycke, Sigvard Olofsson, Stig Jeansson, Marita Lundström, Roelf Datema, Jan-Eric Månsson
Publikováno v:
Virology. 161:385-394
Lectins with narrow oligosaccharide specificities were established as probes to study the host cell influence on the biosynthesis of O-linked oligosaccharides of the herpes simplex virus type 1 (HSV-1)-specified glycoprotein C (gC-1). We found that o
Publikováno v:
Antimicrobial Agents and Chemotherapy. 32:1807-1812
The acyclic guanosine analog (R,S)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine, (+/-)2HM-HBG, is an effective inhibitor of herpes simplex virus and varicella-zoster virus infections in vitro. This report is concerned with the pharmacokinetic evaluati
Autor:
Ralph T. Schwarz, Roelf Datema
Publikováno v:
Bioscience Reports. 4:213-221
The guanosine disphospate and uridine diphosphate esters of the antiviral sugar analog 2-deoxy-2-fluoro-D-glucose (GDP-FGlc and UDP-FGlc) were synthesized and tested as inhibitors of formation of lipid-linked sugars in cell-free extracts. Formation o
Publikováno v:
Antiviral Research. 7:303-316
Buciclovir is an example of an antiherpes, acyclic guanosine analog activated by the viral thymidine kinase and inhibiting viral DNA synthesis in infected cells. An investigation of closely related buciclovir-analogs with similar antiherpes activitie
Publikováno v:
Biochemical Society Transactions. 7:322-326
Autor:
Gunnar Antoni, Bengt Långström, Roelf Datema, Stefan Oscarson, Curt R. Enzell, Ragnar Ryhage, Roland Isaksson
Publikováno v:
Acta Chemica Scandinavica. :152-156
Publikováno v:
Virology
The roles of glucose and mannose trimming in the maturation of Sindbis virus in BHK cells have been investigated using inhibitors of glycoprotein oligosaccharide processing. In the presence of the glucosidase inhibitor N -methyl-1-deoxynojirimycin th