The effect of certolizumab drug concentration and anti-drug antibodies on TNF neutralisation

Autor: Lea C, Berkhout, Erik H, Vogelzang, Margreet M, Hart, Floris C, Loeff, Lisanne, Dijk, Ninotska I L, Derksen, Roeland, Wieringa, W Astrid, van Leeuwen, Charlotte L M, Krieckaert, Annick, de Vries, Michael T, Nurmohamed, Gerrit J, Wolbink, Theo, Rispens

Publikováno v: Clinical and experimental rheumatology. 38(2)

Tumour necrosis factor (TNF) inhibitors like certolizumab, elicit an immunogenic response leading to the formation of anti-drug antibodies (ADAs). We sought to mechanistically investigate the relationship between certolizumab concentrations, ADAs, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::266561cf597d9f5586a130c9fe2f9f1d
https://pubmed.ncbi.nlm.nih.gov/31498069

Intra- and Intermolecular Disulfide Bonds of theGP 2b Glycoprotein of Equine Arteritis Virus: Relevance forVirus Assembly andInfectivity

Autor: Peter J. M. Rottier, Sabine M. Post, Antoine A.F. de Vries, Roeland Wieringa

Publikováno v: Journal of Virology. 77:12996-13004

Equine arteritis virus (EAV) is an enveloped, positive-strand RNA virus belonging to the family Arteriviridae of the order Nidovirales . EAV virions contain six different envelope proteins. The glycoprotein GP 5 (previously named G L ) and the unglyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a67f7f11f3ca8f3caa3b67e0bb4254
https://doi.org/10.1128/jvi.77.24.12996-13004.2003

Formation of Disulfide-Linked Complexes between the Three Minor Envelope Glycoproteins (GP 2b , GP 3 , and GP 4 ) of Equine Arteritis Virus

Autor: Peter J. M. Rottier, Antoine A. F. de Vries, Roeland Wieringa

Publikováno v: Journal of Virology. 77:6216-6226

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales . Six transmembrane proteins have been identified in EAV particles: the nonglycosylated membrane protein M and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bb31e757b359276e5a74da5f3e0d0e
https://doi.org/10.1128/jvi.77.11.6216-6226.2003

Golimumab trough levels, antidrug antibodies and clinical response in patients with rheumatoid arthritis treated in daily clinical practice

Autor: Roeland Wieringa, Dora Pascual-Salcedo, Theo Rispens, Charlotte L M Krieckaert, M Teresa López-Casla, Gertjan Wolbink, Chamaida Plasencia, Michael T. Nurmohamed, E. Kneepkens, Desiree van der Kleij

Publikováno v: Annals of the Rheumatic Diseases, 73(12), 2217-2219. BMJ Publishing Group
Kneepkens, E L, Plasencia, C, Krieckaert, C L M, Pascual-Salcedo, D, van der Kleij, D, Nurmohamed, M T, Lopez-Casla, M T, Wieringa, R, Rispens, T & Wolbink, G 2014, ' Golimumab trough levels, antidrug antibodies and clinical response in patients with rheumatoid arthritis treated in daily clinical practice ', Annals of the Rheumatic Diseases, vol. 73, no. 12, pp. 2217-2219 . https://doi.org/10.1136/annrheumdis-2014-205983
Annals of the rheumatic diseases, 73(12), 2217-2219. BMJ Publishing Group

Tumour necrosis factor inhibitors (TNFi) are effective in the majority of patients with rheumatoid arthritis (RA),1 however, an important reason for non-response is low drug level due to immunogenicity.2 To our knowledge, no data collected during a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c9e00d790e7c641425b994e6ce8cbc
https://pubmed.ncbi.nlm.nih.gov/25261580

Targeted Chromosomal Insertion of Large DNA into the Human Genome by a Fiber-Modified High-Capacity Adenovirus-Based Vector System

Autor: Roeland Wieringa, Maria G. Pau, Gijsbert P. van Nierop, Manuel A F V Gonçalves, Antoine A.F. de Vries, Maarten Holkers

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 8, p e3084 (2008)

A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b1481c9cbf8ba7ba9555ac5130e7d
https://doi.org/10.1371/journal.pone.0003084