Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Roeland, Hanemaaijer"'
Autor:
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models. Here, we investigated the mec
Externí odkaz:
https://doaj.org/article/655a3f5a3c6143cd8f62fdeaec52efc2
Autor:
Lars Verschuren, Anne Linde Mak, Arianne van Koppen, Serdar Özsezen, Sonia Difrancesco, Martien P. M. Caspers, Jessica Snabel, David van der Meer, Anne-Marieke van Dijk, Elias Badal Rashu, Puria Nabilou, Mikkel Parsberg Werge, Koen van Son, Robert Kleemann, Amanda J. Kiliaan, Eric J. Hazebroek, André Boonstra, Willem P. Brouwer, Michail Doukas, Saurabh Gupta, Cornelis Kluft, Max Nieuwdorp, Joanne Verheij, Lise Lotte Gluud, Adriaan G. Holleboom, Maarten E. Tushuizen, Roeland Hanemaaijer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibr
Externí odkaz:
https://doaj.org/article/6be533e026b74a099d1ef00fbf2fcead
Autor:
Jennifer Venhorst, Roeland Hanemaaijer, Remon Dulos, Martien P. M. Caspers, Karin Toet, Joline Attema, Christa de Ruiter, Gino Kalkman, Tanja Rouhani Rankouhi, Jelle C. B. C. de Jong, Lars Verschuren
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
An in silico target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH)-induced liver fibrosis. This approach integrates text mining, network b
Externí odkaz:
https://doaj.org/article/2ed7e1d7d253401ab02b8a54abdd0c8d
Autor:
Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M. Mato, Roeland Hanemaaijer, Cristina Alonso, Robert Kleemann
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1513-1532 (2018)
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventio
Externí odkaz:
https://doaj.org/article/b7dbea0375ad493383bf24d4d1bb040c
Autor:
Eveline Gart, Wim van Duyvenvoorde, Karin Toet, Martien P. M. Caspers, Lars Verschuren, Mette Juul Nielsen, Diana Julie Leeming, Everton Souto Lima, Aswin Menke, Roeland Hanemaaijer, Jaap Keijer, Kanita Salic, Robert Kleemann, Martine C. Morrison
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1954 (2021)
In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH-associated mortality. The short-chain fatty acid butyrate can exert metab
Externí odkaz:
https://doaj.org/article/d68615dbae2a4f9ab2273c659445ae93
Autor:
Martine C. Morrison, Robert Kleemann, Arianne van Koppen, Roeland Hanemaaijer, Lars Verschuren
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined i
Externí odkaz:
https://doaj.org/article/b8d39cfa767c4bd4bb4053c1ecf78829
Autor:
Koen C. van Son, Lars Verschuren, Roeland Hanemaaijer, Helen Reeves, R. Bart Takkenberg, Joost P. H. Drenth, Maarten E. Tushuizen, Adriaan G. Holleboom
Publikováno v:
Cancers, 15, 4
Cancers, 15
Cancers, 15(4). MDPI
Cancers, 15
Cancers, 15(4). MDPI
Simple Summary The incidence of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD) has increased in recent years. Compared to HCC caused by other chronic liver diseases, NAFLD-related HCC is often detected later
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63f1dc9cb06636fae7bcbc8aca0e105
Autor:
Arianne van Koppen, Lars Verschuren, Anita M. van den Hoek, Joanne Verheij, Martine C. Morrison, Kelvin Li, Hiroshi Nagabukuro, Adalberto Costessi, Martien P.M. Caspers, Tim J. van den Broek, John Sagartz, Cornelis Kluft, Carine Beysen, Claire Emson, Alain J. van Gool, Roel Goldschmeding, Reinout Stoop, Ivana Bobeldijk-Pastorova, Scott M. Turner, Guido Hanauer, Roeland Hanemaaijer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 83-98.e10 (2018)
The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynam
Externí odkaz:
https://doaj.org/article/592b66b824aa47b5807c7f2ccfe9465f
Autor:
Anita M. van den Hoek, Serdar Özsezen, Martien P.M Caspers, Geurt Stokman, Arianne van Koppen, Roeland Hanemaaijer, Lars Verschuren
Publikováno v:
Journal of Hepatology. 77:S685-S686
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7952543d8f290936ee890c5dfffaa848
https://doi.org/10.1016/s0168-8278(22)01689-0
https://doi.org/10.1016/s0168-8278(22)01689-0
Autor:
Anita M. van den Hoek, Serdar Özsezen, Martien P. M. Caspers, Arianne van Koppen, Roeland Hanemaaijer, Lars Verschuren
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8229
The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6e610d14d7f48cabc5ef529d3927f5
https://doi.org/10.3390/ijms23158229
https://doi.org/10.3390/ijms23158229