Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roel Wijtmans"'
Autor:
J.C.M. van Hest, Kaspar Koch, Roel Wijtmans, Hans E. Schoemaker, Floris P. J. T. Rutjes, R. J. Van Den Berg, Pieter J. Nieuwland
Publikováno v:
Biotechnology and Bioengineering, 99, 4, pp. 1028-1033
Biotechnology and Bioengineering, 99, 1028-1033
Biotechnology and Bioengineering, 99, 1028-1033
We have demonstrated that multiple crude enzyme lysates containing a hydroxynitrile lyase can be used for the enantioselective synthesis of cyanohydrins from aldehydes in microchannels. Using a microreactor setup, two important parameters were effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fe18889b7005f8a8cd4180b0c94c62
https://doi.org/10.1002/bit.21649
https://doi.org/10.1002/bit.21649
Autor:
Hans E. Schoemaker, Rutger J. F. van den Berg, Richard H. Blaauw, Theo Sonke, Roel Wijtmans, Marloes A. Wijdeven, Richard W. Fitch, Floris P. J. T. Rutjes, Floris van Delft, John W. Daly, Wim L. Noorduin, Thomas F. Spande
Publikováno v:
Organic Letters, 10, 4001-4003
Organic Letters, 10, 18, pp. 4001-4003
Organic Letters, 10, 18, pp. 4001-4003
A stereoselective synthesis of (+)-epiquinamide is presented in combination with determination of the absolute configuration of the natural product. Key steps in the sequence involved chemoenzymatic formation of an enantiomerically pure cyanohydrin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7da1de52d97f43356b58d4448db0fb
https://pubmed.ncbi.nlm.nih.gov/18702495
https://pubmed.ncbi.nlm.nih.gov/18702495
Autor:
Hans E. Schoemaker, Rutger J. F. van den Berg, Roel Wijtmans, Kaspar Koch, Jan C. M. van Hest, Pieter J. Nieuwland, Marcel Wubbolts, Floris P. J. T. Rutjes
Publikováno v:
Chemical Engineering Journal (1997), 135, S89-S92
Chemical Engineering Journal (1997), 135, pp. S89-S92
Chemical Engineering Journal (1997), 135, pp. S89-S92
The synthesis of optically pure cyanohydrins using a crude cell lysate containing the enzyme hydroxynitrile lyase (HNL) was studied in a microreactor in an aqueous–organic biphasic system. Different aldehyde substrates were selected to be converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4e5eed9e56848b405e40ca545e89b6
http://hdl.handle.net/2066/70363
http://hdl.handle.net/2066/70363
Autor:
Floris P. J. T. Rutjes, Christien A. Schortinghuis, Rutger J. F. van den Berg, Mandy K. S. Vink, Helmut Schwab, Roel Wijtmans, Christoph Reisinger, Hans E. Schoemaker
Publikováno v:
Biotechnology journal. 1(5)
The nitrile hydrolyzing properties of the bacterium strain Rhodococcus erythropolis NCIMB 11540 have been investigated. Using whole cells of the microorganism, a wide variety of aromatic and aliphatic cyanide-containing substrates was successfully hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e777d294e1864bec71ff4ed5e1ffec
https://pubmed.ncbi.nlm.nih.gov/16892293
https://pubmed.ncbi.nlm.nih.gov/16892293
Autor:
Hans E. Schoemaker, Floris P. J. T. Rutjes, Roel Wijtmans, Marloes A. Wijdeven, Peter N. M. Botman, Richard H. Blaauw
Publikováno v:
Organic Letters, 7, 4005-4007
Organic Letters, 7, 18, pp. 4005-4007
Organic Letters, 7(18), 4005-4007. American Chemical Society
Organic Letters, 7, 18, pp. 4005-4007
Organic Letters, 7(18), 4005-4007. American Chemical Society
The stereoselective total synthesis of the novel quinolizidine alkaloid (+)-epiquinamide is presented, starting from the amino acid l-allysine ethylene acetal. Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc281891e7f5273066a76293e6a20e5
http://hdl.handle.net/2066/33163
http://hdl.handle.net/2066/33163
Autor:
Richard H. Blaauw, Mandy K. S. Vink, Roel Wijtmans, F.P.J.T. Rutjes, F.L. van Delft, Hans E. Schoemaker
Publikováno v:
ChemInform. 35
C-Functionalized morpholines are found in a variety of natural products and biologically active compounds, but have also for other reasons been applied in organic synthesis. This review deals with the biological relevance of C-substituted morpholines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9655b2045fe7de8c926307e08af2173a
https://doi.org/10.1002/chin.200427266
https://doi.org/10.1002/chin.200427266
Vinylaziridines are useful and versatile synthetic intermediates, as the relief of ring-strain provides a driving force for efficient ring-opening or ring-expansion reactions. Furthermore, the vinyl group can be derivatized into interesting functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b28bb179f23ec3edc69483d73c3f3e
http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-109688
http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-109688
N,N-Acetals as N-Acyliminium Ion Precursors: Synthesis and Absolute Stereochemistry of Epiquinamide.
Autor:
Marloes A. Wijdeven, Roel Wijtmans, Rutger J. F. van den Berg, Wim Noorduin, Hans E. Schoemaker, Theo Sonke, Floris L. van Delft, Richard H. Blaauw, Richard W. Fitch, Thomas F. Spande, John W. Daly, Floris P. J. T. Rutjes
Publikováno v:
Organic Letters; Aug2008, Vol. 10 Issue 18, p4001-4003, 3p