Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Roel Q. J. Schaapveld"'
1
Akademický článek
The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis
Autor: Marion T. J. van den Bosch, Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Chantal L. Duurland, Rianne Biemans, Ludwig J. Dubois, Laurens A. H. van Pinxteren, Roel Q. J. Schaapveld, Michel Janicot
Publikováno v: Frontiers in Drug Discovery, Vol 3 (2023)
As cancer is a multifactorial disease, the multimodal action of microRNAs makes them an attractive tool for novel therapeutic approaches. The tumor suppressive miR-7-5p has been shown to act on many aspects of oncogenesis, including cell proliferatio
Externí odkaz: https://doaj.org/article/39e32167fc4c42c8971d2b5dfc2308e8
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3
Akademický článek
A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability.
Autor: Jos B Poell, Rick J van Haastert, Thijs de Gunst, Iman J Schultz, Willemijn M Gommans, Mark Verheul, Francesco Cerisoli, Andre A F L van Puijenbroek, Paula I van Noort, Gregoire P Prevost, Roel Q J Schaapveld, Edwin Cuppen
Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43569 (2012)
Malignant melanoma is an aggressive form of skin cancer with poor prognosis. Despite improvements in awareness and prevention of this disease, its incidence is rapidly increasing. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate ce
Externí odkaz: https://doaj.org/article/d40c736567e848e5920930dd9625597e
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4
Antagonizing Increased
Autor: Vamshidhar R, Vangoor, Cristina R, Reschke, Ketharini, Senthilkumar, Lieke L, van de Haar, Marina, de Wit, Giuliano, Giuliani, Mark H, Broekhoven, Gareth, Morris, Tobias, Engel, Gary P, Brennan, Ronan M, Conroy, Peter C, van Rijen, Peter H, Gosselaar, Stephanie, Schorge, Roel Q J, Schaapveld, David C, Henshall, Pierre N E, De Graan, R Jeroen, Pasterkamp
Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(26)
Mesial temporal lobe epilepsy (mTLE) is a chronic neurological disease characterized by recurrent seizures. The antiepileptic drugs currently available to treat mTLE are ineffective in one-third of patients and lack disease-modifying effects. miRNAs,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04e536ed66bd35d9a24aacd44e0c67dc
https://pubmed.ncbi.nlm.nih.gov/31015341
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5
Correction: A Functional Screen Identifies Specific MicroRNAs Capable of Inhibiting Human Melanoma Cell Viability
Autor: Jos B. Poell, Rick J. van Haastert, Thijs de Gunst, Iman J. Schultz, Willemijn M. Gommans, Mark Verheul, Francesco Cerisoli, Andre A.F.L. van Puijenbroek, Paula I. van Noort, Gregoire P. Prevost, Roel Q. J. Schaapveld, Edwin Cuppen
Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 1 (2013)
Malignant melanoma is an aggressive form of skin cancer with poor prognosis. Despite improvements in awareness and prevention of this disease, its incidence is rapidly increasing. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1081e862857698711587d6c6254b4a8
https://pubmed.ncbi.nlm.nih.gov/22927992
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6
miRNA-520f Reverses Epithelial-to-Mesenchymal Transition by Targeting
Autor: Jasmijn G M, van Kampen, Onno, van Hooij, Cornelius F, Jansen, Frank P, Smit, Paula I, van Noort, Iman, Schultz, Roel Q J, Schaapveld, Jack A, Schalken, Gerald W, Verhaegh
Publikováno v: Cancer research. 77(8)
Reversing epithelial-to-mesenchymal transition (EMT) in cancer cells has been widely considered as an approach to combat cancer progression and therapeutic resistance, but a limited number of broadly comprehensive investigations of miRNAs involved in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0415d4ee3cf49bfd0cb38a84609582e5
https://pubmed.ncbi.nlm.nih.gov/28209612
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7
Intracellular Delivery of the p38 Mitogen-Activated Protein Kinase Inhibitor SB202190 [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in Renal Tubular Cells: A Novel Strategy to Treat Renal Fibrosis
Autor: Roel Q. J. Schaapveld, György Kéri, Maria Sandovici, Robert H. Henning, Frits Moolenaar, Robbert J. Kok, Marie Lacombe, Martin H. de Borst, Jai Prakash, Klaas Poelstra, Johannes H. Proost, Vinay Saluja, Harry van Goor, Dirk K. F. Meijer
Publikováno v: Journal of Pharmacology and Experimental Therapeutics, 319(1), 8-19. WILLIAMS & WILKINS
During renal injury, activation of p38 mitogen-activated protein kinase (MAPK) in proximal tubular cells plays an important role in the inflammatory events that eventually lead to renal fibrosis. We hypothesized that local inhibition of p38 within th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4d69c65dac65f643be6cd8c970cdf5
https://doi.org/10.1124/jpet.106.106054
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8
A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability
Autor: Jos B, Poell, Rick J, van Haastert, Thijs, de Gunst, Iman J, Schultz, Willemijn M, Gommans, Mark, Verheul, Francesco, Cerisoli, Andre A F L, van Puijenbroek, Paula I, van Noort, Gregoire P, Prevost, Roel Q J, Schaapveld, Edwin, Cuppen
Publikováno v: PLoS ONE
PLoS One, 7(8). Public Library of Science
PLoS ONE, Vol 7, Iss 8, p e43569 (2012)
Malignant melanoma is an aggressive form of skin cancer with poor prognosis. Despite improvements in awareness and prevention of this disease, its incidence is rapidly increasing. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ca73bb2d5645163f919233ba9b9703
https://pubmed.ncbi.nlm.nih.gov/29364961
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