Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Roel P L, Bell"'
Autor:
Xiaowen Peng, James C. Lanter, Angela Y.-P. Chen, Morgan A. Brand, Mary K. Wozniak, Steven Hoekman, Ondřej Longin, Hendrik Regeling, Wim Zonneveld, Roel P. L. Bell, Gerhard Koenig, Raymond S. Hurst, Jean-François Blain, Duane A. Burnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 80
Phenotypic screening of an annotated small molecule library and initial SAR studies identified compound 2 as a robust enhancer of progranulin secretion. Detailed SAR development on conformationally restricted carbamate isosteres led to the identifica
Autor:
Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:223-236
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on
Publikováno v:
ChemInform. 29
Publikováno v:
ChemInform. 32
A general and efficient route to the marasmane skeleton is described. Total syntheses of two simple marasmanes (35 and 37) in racemic form were achieved using a MgI2-catalyzed rearrangement−cyclopropanation reaction of trimethylsilyl enol ether 31
Publikováno v:
The Journal of organic chemistry. 63(1)
It is observed that mesylate 1 on exposure to Li(Ot-Bu)(3)AlH in refluxing toluene rearranges selectively to the 11-oxatricyclo[5.3.1.0(2,6)]undecane derivative 3. A similar rearrangement, leading to a bridged tricyclic ether (14 --5), has been used
Publikováno v:
Journal of Organic Chemistry 66 (2001) 7
Journal of Organic Chemistry, 66(7), 2350-2357
Journal of Organic Chemistry, 66(7), 2350-2357
A general and efficient route to the marasmane skeleton is described. Total syntheses of two simple marasmanes (35 and 37) in racemic form were achieved using a MgI2-catalyzed rearrangement−cyclopropanation reaction of trimethylsilyl enol ether 31