Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Roel Ottenhoff"'
1
Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Autor: Albert H. Bootsma, Ronald P.J. Oude Elferink, D. Rudi de Waart, Albert H. van Gennip, Christoph G. Dietrich, Roel Ottenhoff
Publikováno v: Carcinogenesis. 22:805-811
While metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived heterocyclic amine and carcinogen, has been studied extensively in several species, transport of this compound and its metabolites has not been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::803b0515a824f8efc69623c1d5e4cb33
https://doi.org/10.1093/carcin/22.5.805
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2
Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice☆☆☆
Autor: Rick Havinga, Folkert Kuipers, Hans M.G. Princen, Ronald P.J. Oude Elferink, Henk Wolters, Roel Ottenhoff, Albert K. Groen, Peter J. Voshol
Publikováno v: Gastroenterology, 114(5), 1024-1034. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 114(5), 1024-1034. W.B. Saunders Ltd
Background & Aims: mdr2 P-glycoprotein (Pgp) deficiency in mice leads to the absence of biliary phospholipids and cholesterol in the presence of normal bile salt secretion. The aim of this study was to evaluate the importance of the biliary pathway i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f0b3e7400d0446108764f138cdd3b4
https://doi.org/10.1016/s0016-5085(98)70323-3
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3
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
Autor: L. Van Deemter, Roel Ottenhoff, M van Roon, A.K. Groen, A Berns, M. A. Van Der Valk, C. A. A. M. Mol, J. J. M. Smit, N. M. T. Van Der Lugt, G.J.A. Offerhaus, Els Wagenaar, Piet Borst, R.P.J. Oude Elferink, A.H. Schinkel
Publikováno v: Cell, 75(3), 451-462. Cell Press
Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The latter is encoded by the human MDR3 (also called MDR2) and the mouse mdr2 genes, an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d4968b83431e10d7af0fa8aa1e196d
https://doi.org/10.1016/0092-8674(93)90380-9
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4
Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats
Autor: Ivo G. Schoots, Roel Ottenhoff, D. Rudi de Waart, Christoph G. Dietrich, Ronald P.J. Oude Elferink
Publikováno v: Molecular pharmacology. 59(5)
MRP2 is an apical transporter expressed in hepatocytes and the epithelial cells of the small intestine and kidney proximal tubule. It extrudes organic anions, conjugated compounds, and some uncharged amphipaths. We studied the transport of an abundan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99371223eb4156f0a92e0850b9fb8b86
https://pubmed.ncbi.nlm.nih.gov/11306678
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5
Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
Autor: Roel Ottenhoff, Alexander J. Smith, J.Marleen L. De Vree, Ronald P.J. Oude Elferink, Piter J. Bosma, Jan Aten
Publikováno v: Gastroenterology, 119(6), 1720-1730. W.B. Saunders Ltd
Scopus-Elsevier
Background & Aims: Patients with progressive familial intrahepatic cholestasis (PFIC) type 3 have a mutation in the MDR3 gene, encoding the hepatocanalicular phospholipid translocator. In general, liver failure develops within the first decade of lif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a016a51a74e4741b8bc464c09161acb3
https://pure.amc.nl/en/publications/correction-of-liver-disease-by-hepatocyte-transplantation-in-a-mouse-model-of-progressive-familial-intrahepatic-cholestasis(f4452bb2-c2a9-4cd3-9b69-0d2a75ba39d0).html
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6
Regulation of mdr2 P-glycoprotein expression by bile salts
Autor: Albert K. Groen, C. M. G. Frijters, M. J. A. Van Wijland, R. P. J. Oude Elferink, Roel Ottenhoff, C. M. J. Van Nieuwkerk
Publikováno v: Biochemical journal, 321(2), 389-395. Portland Press Ltd.
The phosphatidyl translocating activity of the mdr2 P-glycoprotein (Pgp) in the canalicular membrane of the mouse hepatocyte is a rate-controlling step in the biliary secretion of phospholipid. Since bile salts also regulate the secretion of biliary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0895b9808d363afa9dab724ad4a89f1b
https://pure.amc.nl/en/publications/regulation-of-mdr2-pglycoprotein-expression-by-bile-salts(86a6fc95-e481-4652-aec1-ad14cefd7d71).html
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