Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Roel M. van Harten"'
Autor:
Roel M. van Harten, Johanna L.M. Tjeerdsma-van Bokhoven, Astrid de Greeff, Melanie D. Balhuizen, Albert van Dijk, Edwin J.A. Veldhuizen, Henk P. Haagsman, Maaike R. Scheenstra
Publikováno v:
Journal of Advanced Research, Vol 36, Iss , Pp 101-112 (2022)
Introduction: Due to the increase of antibiotic resistant bacterial strains, there is an urgent need for development of alternatives to antibiotics. Cathelicidins can be such an alternative to antibiotics having both a direct antimicrobial capacity a
Externí odkaz:
https://doaj.org/article/56f2c3a709914fcabbd62c5e4030ba46
Autor:
Jesús Pérez-Ortega, Roel M. Van Harten, Ria Van Boxtel, Michel Plisnier, Marc Louckx, Dominique Ingels, Henk P. Haagsman, Jan Tommassen
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 1452-1468 (2021)
Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of
Externí odkaz:
https://doaj.org/article/f279f887fb2d47fea4b021ea83261fa8
Autor:
Lianci Peng, Maaike R. Scheenstra, Roel M. van Harten, Henk P. Haagsman, Edwin J. A. Veldhuizen
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-12 (2020)
Abstract Cathelicidins (CATHs) play an important role in the innate immune response against microbial infections. Among the four chicken cathelicidins, CATH-B1 is studied the least. In this study, the effect of CATH-B1 on the macrophage response towa
Externí odkaz:
https://doaj.org/article/6c0c19975e484945874af7b9015289ff
Autor:
Melanie D. Balhuizen, Chantal M. Versluis, Roel M. van Harten, Eline F. de Jonge, Jos F. Brouwers, Chris H.A. van de Lest, Edwin J.A. Veldhuizen, Jan Tommassen, Henk P. Haagsman
Publikováno v:
Current Research in Microbial Sciences, Vol 2, Iss , Pp 100010- (2021)
Host defense peptides (HDPs), such as cathelicidins, are small, cationic, amphipathic peptides and represent an important part of the innate immune system. Most cathelicidins, including the porcine PMAP-36, are membrane active and disrupt the bacteri
Externí odkaz:
https://doaj.org/article/50ce85dddf5846178b3ee968d0292b68
Autor:
Maaike R. Scheenstra, Roel M. van Harten, Edwin J. A. Veldhuizen, Henk P. Haagsman, Maarten Coorens
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cathelicidins are short cationic peptides that are part of the innate immune system. At first, these peptides were studied mostly for their direct antimicrobial killing capacity, but nowadays they are more and more appreciated for their immunomodulat
Externí odkaz:
https://doaj.org/article/0f32eed78e5645e0889a37cbafdb3227
Publikováno v:
Vaccines, Vol 6, Iss 3, p 63 (2018)
Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics lik
Externí odkaz:
https://doaj.org/article/73cd60f26d3f43419be82500823beeb0
Publikováno v:
Research in Microbiology. :104049
To develop a Bordetella bronchiseptica vaccine with reduced endotoxicity, we previously inactivated lpxL1, the gene encoding the enzyme that incorporates a secondary 2-hydroxy-laurate in lipid A. The mutant showed a myriad of phenotypes. Structural a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0161d529aa97c11fe0f45654bd11076b
https://doi.org/10.1016/j.resmic.2023.104049
https://doi.org/10.1016/j.resmic.2023.104049
Autor:
Thomas M. Wood, Małgorzata Śleszyńska, Nathaniel I. Martin, Antoni P. A. Hendrickx, Eefjan Breukink, Peter 't Hart, Rob J. L. Willems, Inmaculada Rentero Rebollo, Kamaleddin Haj Mohammad Ebrahim Tehrani, Roel M. van Harten
Publikováno v:
Chemical Science, 8(12), 7991. Royal Society of Chemistry
Chemical Science, 8(12), 7991-7997
Chemical Science, 8(12), 7991-7997
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fada92c0189fcf3e891b27e8162673
https://doi.org/10.1039/c7sc03413j
https://doi.org/10.1039/c7sc03413j
Publikováno v:
Trends in Microbiology, 25(6), 467. Elsevier Limited
Over the past two decades infections due to antibiotic-resistant bacteria have escalated world-wide, affecting patient morbidity, mortality, and health care costs. Among these bacteria, Enterococcus faecium and Enterococcus faecalis represent opportu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e400e46966a2ce6e49438a17e091adb4
https://dspace.library.uu.nl/handle/1874/361404
https://dspace.library.uu.nl/handle/1874/361404
