Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Roel G W, Verhaak"'
Autor:
Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F. Bruns, Khaja Syed, James A. Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S. Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A. Care, Luisa Cutillo, David R. Westhead, Susan C. Short, Michael D. Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G. W. Verhaak, Lucy F. Stead
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing da
Externí odkaz:
https://doaj.org/article/190c474079fc465a883fccd59c89b7b7
Autor:
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Aram S. Modrek, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G. W. Verhaak, Erik P. Sulman
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-23 (2022)
Abstract Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed “CAPTURE”, a single-cell barcoding approach to comprehensive
Externí odkaz:
https://doaj.org/article/e91108592f504fbf93459cedf14bc51e
Autor:
Manako Yamaguchi, Hirofumi Nakaoka, Kazuaki Suda, Kosuke Yoshihara, Tatsuya Ishiguro, Nozomi Yachida, Kyota Saito, Haruka Ueda, Kentaro Sugino, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Sundaramoorthy Revathidevi, Teiichi Motoyama, Kazuki Tainaka, Roel G. W. Verhaak, Ituro Inoue, Takayuki Enomoto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Through regeneration, the endometrium accumulates somatic mutations that can lead to diseases like endometriosis and cancer. Here, the authors use genomics to analyse normal endometrial glands from different patient cohorts, detect rhizome structures
Externí odkaz:
https://doaj.org/article/489f82bf348f4647b67f1068544d1ba2
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. L. Bhat, Thanh-Thuy T. Le, Floris P. Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G. W. Verhaak, Kenneth D. Aldape, Erik P. Sulman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood. We demonstrate that podoplanin (PDPN) expression is an indepe
Externí odkaz:
https://doaj.org/article/17361cb6986142ceaa84f9b6ee8f62af
Autor:
Yona Kim, Frederick S. Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G. W. Verhaak, Sun Ha Paek
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain tumor, still portends a poor prognosis with a median overall survival of 12–16 months. The complexity of GBM treatment mainly lies in the inter- and intr
Externí odkaz:
https://doaj.org/article/f9d5a299ebbd44bc8b99d034e1b64aff
Autor:
Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K. Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G. W. Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Chemotherapy resistance in recurrent gliomas is a large hurdle for successful therapy. Here, the authors show that some recurrent gliomas harbour O-6-methylguanine-DNA methyltransferase (MGMT) genomic rearrangements, and in vitro and in vivo these co
Externí odkaz:
https://doaj.org/article/7b8914f315a045a59cf1cda9e3456735
Autor:
Jason K. Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P. Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P. Sulman, Amy B. Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone, Roel G. W. Verhaak, Do-Hyun Nam
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are gen
Externí odkaz:
https://doaj.org/article/e8da640943fc48ff98c50176324f09fa
Autor:
Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Annalise C. Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M. Lippman, Roel G. W. Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Brian J. Reid, Rebecca C. Fitzgerald, Thomas G. Paulson, Howard Y. Chang, Sihan Wu, Vineet Bafna, Paul S. Mischel
Publikováno v:
Luebeck, J, Ng, A W T, Galipeau, P C, Li, X, Sanchez, C A, Katz-Summercorn, A C, Kim, H, Jammula, S, He, Y, Lippman, S M, Verhaak, R G W, Maley, C C, Alexandrov, L B, Reid, B J, Fitzgerald, R C, Paulson, T G, Chang, H Y, Wu, S, Bafna, V & Mischel, P S 2023, ' Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus ', Nature, vol. 616, no. 7958, pp. 798-805 . https://doi.org/10.1038/s41586-023-05937-5
Nature, 616(7958), 798-805. Nature Publishing Group
Nature, 616(7958), 798-805. Nature Publishing Group
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer1–6. At present, it is unclear whether ecDNA is a later manifesta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b79f4c574e7c40779822effa0cc3bcc
http://www.scopus.com/inward/record.url?scp=85152435510&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85152435510&partnerID=8YFLogxK
Publikováno v:
Yi, E, Chamorro González, R, Henssen, A G & Verhaak, R G W 2022, ' Extrachromosomal DNA amplifications in cancer ', Nature Reviews Genetics, vol. 23, no. 12, pp. 760-771 . https://doi.org/10.1038/s41576-022-00521-5
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse patient outcome. The functional impact of ecDNA has been linked to its unique properties, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c9176cce6f3f0d17311301070057c0
http://www.scopus.com/inward/record.url?scp=85136004159&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85136004159&partnerID=8YFLogxK