Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Roel Docter"'
Publikováno v:
European Thyroid Journal. 8:169-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c3c29e3fdda76f6dba12066d1de18f
https://doi.org/10.1159/000500417
https://doi.org/10.1159/000500417
Publikováno v:
American Journal of Physiology, Endocrinology and Metabolism, 283, 1232-1238. American Physiological Society
Liver uptake of thyroxine (T4) is mediated by transporters and is rate limiting for hepatic 3,3′,5-triiodothyronine (T3) production. We investigated whether hepatic mRNA for T4transporters is regulated by thyroid state using Xenopus laevis oocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f924a2ae81a331e70cdc05713dec1a
https://doi.org/10.1152/ajpendo.00214.2002
https://doi.org/10.1152/ajpendo.00214.2002
Autor:
François Verrey, Eric P. Krenning, Ellis P. C. M. Moerings, Georg Hennemann, Roel Docter, Edith C. H. Friesema, Theo J. Visser
Publikováno v:
Endocrinology. 142:4339-4348
Transport of thyroid hormone across the cell membrane is required for thyroid hormone action and metabolism. We have investigated the possible transport of iodothyronines by the human system L amino acid transporter, a protein consisting of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f84b136ffd88465fb3d8b9ef4489b
https://doi.org/10.1210/endo.142.10.8418
https://doi.org/10.1210/endo.142.10.8418
Publikováno v:
Metabolism. 43:1355-1361
The transport and subsequent metabolism of triiodothyronine (T3) were studied in isolated perfused livers of euthyroid, hypothyroid, and hyperthyroid rats, both fed and 48-hour-fasted. T3 kinetics (transport and metabolism) during perfusion were eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ac7ddc5754baeb2e6717dbc75e084d
https://doi.org/10.1016/0026-0495(94)90027-2
https://doi.org/10.1016/0026-0495(94)90027-2
Publikováno v:
Clinical Endocrinology. 40:751-758
Summary BACKGROUND Abnormalities of the serum thyroid hormone binding proteins are not uncommon but, when properly asessed, they do not present diagnostic difficulties. In contrast, the presence of two inherited defects of thyroid hormone transport,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5861ec43924c7c0b3b49b7140b408e
https://doi.org/10.1111/j.1365-2265.1994.tb02508.x
https://doi.org/10.1111/j.1365-2265.1994.tb02508.x
Autor:
Georg Hennemann, Eric P. Krenning, Hans van Toor, Bert F. Bernard, Marion de Jong, Chen-Fee Lim, Roel Docter
Publikováno v:
Clinical Endocrinology. 40:79-85
Summary OBJECTIVE Inhibitors of cellular T4 transport leading to diminished plasma T3 production have been identified as 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) and indoxyl sulphate in uraemia and bilirubin and non-esterified fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328533610d9fd9beaea8a45648e7f231
https://doi.org/10.1111/j.1365-2265.1994.tb02447.x
https://doi.org/10.1111/j.1365-2265.1994.tb02447.x
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 14(4)
Studies in hypothyroid rats show that, when infused with a combination of thyroxine (T4) plus triiodothyronine (T3) to normalize thyrotropin (TSH), euthyroidism in all organs is only ensured when T(4) and T(3) are administered in a ratio as normally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acff8952bdc82172d3b0e815d325a65
https://pubmed.ncbi.nlm.nih.gov/15142360
https://pubmed.ncbi.nlm.nih.gov/15142360
Reduced T3 deiodination by the human hepatoblastoma cell line HepG2 caused by deficient T3 sulfation
Autor:
Roel Docter, Eric P. Krenning, Marion de Jong, Hans J. van der Hoek, Paul G. J. van Stralen, Georg Hennemann, Chen F. Lim
Publikováno v:
Biochimica et biophysica acta. 1157(1)
Type I deiodination of T3 sulfate occurs at a Vmax that is 30-fold higher as compared to T3, both in rat and in human liver homogenates. We now present data showing lack of T3 deiodination by a human liver derived hepatoblastoma cell line, HepG2, cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8eb3a923e4e0c25aa5ab3caa1488fa
https://pubmed.ncbi.nlm.nih.gov/8388730
https://pubmed.ncbi.nlm.nih.gov/8388730
Publikováno v:
Endocrinology. 125:2175-2186
The liver metabolizes T4 by deiodination and conjugation to T4 glucuronide (T4G), but little information exists about the formation of T4 sulfate (T4S) in vivo. We have examined the excretion of T4G, T4S, T3 and rT3 glucuronide (T3G and rT3G) in bile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fea5f528feba7a58bd05b42b44291a5
https://doi.org/10.1210/endo-125-4-2175
https://doi.org/10.1210/endo-125-4-2175