How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities

Autor: Bunne, Charlotte, Roohani, Yusuf, Rosen, Yanay, Gupta, Ankit, Zhang, Xikun, Roed, Marcel, Alexandrov, Theo, AlQuraishi, Mohammed, Brennan, Patricia, Burkhardt, Daniel B., Califano, Andrea, Cool, Jonah, Dernburg, Abby F., Ewing, Kirsty, Fox, Emily B., Haury, Matthias, Herr, Amy E., Horvitz, Eric, Hsu, Patrick D., Jain, Viren, Johnson, Gregory R., Kalil, Thomas, Kelley, David R., Kelley, Shana O., Kreshuk, Anna, Mitchison, Tim, Otte, Stephani, Shendure, Jay, Sofroniew, Nicholas J., Theis, Fabian, Theodoris, Christina V., Upadhyayula, Srigokul, Valer, Marc, Wang, Bo, Xing, Eric, Yeung-Levy, Serena, Zitnik, Marinka, Karaletsos, Theofanis, Regev, Aviv, Lundberg, Emma, Leskovec, Jure, Quake, Stephen R.

The cell is arguably the most fundamental unit of life and is central to understanding biology. Accurate modeling of cells is important for this understanding as well as for determining the root causes of disease. Recent advances in artificial intell

Externí odkaz: http://arxiv.org/abs/2409.11654

How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities.

Autor: Bunne C; Department of Computer Science, Stanford University, Stanford, CA, USA.; Genentech, South San Francisco, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA.; School of Computer and Communication Sciences and School of Life Sciences, EPFL, Lausanne, Switzerland., Roohani Y; Department of Computer Science, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA.; Arc Institute, Palo Alto, CA, USA., Rosen Y; Department of Computer Science, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA., Gupta A; Chan Zuckerberg Initiative, Redwood City, CA, USA.; KTH Royal Institute of Technology, Science for Life Laboratory, Department of Protein Science, Stockholm, Sweden., Zhang X; Department of Computer Science, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Roed M; Department of Computer Science, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA., Alexandrov T; Department of Pharmacology, University of California, San Diego, CA, USA.; Department of Bioengineering, University of California, San Diego, CA, USA., AlQuraishi M; Department of Systems Biology, Columbia University, New York, NY, USA., Brennan P; Chan Zuckerberg Initiative, Redwood City, CA, USA., Burkhardt DB; Cellarity, Somerville, MA, USA., Califano A; Department of Systems Biology, Columbia University, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.; Chan Zuckerberg Biohub New York, NY, USA., Cool J; Chan Zuckerberg Initiative, Redwood City, CA, USA., Dernburg AF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Ewing K; Chan Zuckerberg Initiative, Redwood City, CA, USA., Fox EB; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Biohub San Francisco, CA, USA., Haury M; Chan Zuckerberg Institute for Advanced Biological Imaging, Redwood City, CA, USA., Herr AE; Chan Zuckerberg Biohub San Francisco, CA, USA.; Department of Bioengineering, University of California, Berkeley, CA, USA., Horvitz E; Microsoft Research, Redmond, WA, USA., Hsu PD; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Jain V; Google Research, Mountain View, CA, USA., Johnson GR; NewLimit, San Francisco, CA, USA., Kalil T; Schmidt Futures, USA., Kelley DR; Calico Life Sciences LLC, San Francisco, CA, USA., Kelley SO; Chan Zuckerberg Biohub Chicago, IL, USA.; Northwestern University, Evanston, IL, USA., Kreshuk A; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Mitchison T; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Otte S; Chan Zuckerberg Institute for Advanced Biological Imaging, Redwood City, CA, USA., Shendure J; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Sofroniew NJ; EvolutionaryScale, PBC, USA., Theis F; Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany., Theodoris CV; Gladstone Institute of Cardiovascular Disease, Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Department of Pediatrics, University of California, San Francisco, CA, USA., Upadhyayula S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Chan Zuckerberg Biohub San Francisco, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Valer M; Chan Zuckerberg Initiative, Redwood City, CA, USA., Wang B; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada., Xing E; Carnegie Mellon University, School of Computer Science, Pittsburgh, PA, USA.; Mohamed Bin Zayed University of Artificial Intelligence, Abu Dhabi, United Arab Emirates., Yeung-Levy S; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Zitnik M; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Karaletsos T; Chan Zuckerberg Initiative, Redwood City, CA, USA., Regev A; Genentech, South San Francisco, CA, USA., Lundberg E; Chan Zuckerberg Initiative, Redwood City, CA, USA.; KTH Royal Institute of Technology, Science for Life Laboratory, Department of Protein Science, Stockholm, Sweden.; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., Leskovec J; Department of Computer Science, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Initiative, Redwood City, CA, USA., Quake SR; Chan Zuckerberg Initiative, Redwood City, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Department of Applied Physics, Stanford University, Stanford, CA, USA.

Publikováno v: ArXiv [ArXiv] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.