Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Roeben N, Munji"'
Autor:
Anaamika Campeau, Robert H. Mills, Marie Blanchette, Kaja Bajc, Mario Malfavon, Roeben N. Munji, Liwen Deng, Bryan Hancock, Kathryn A. Patras, Joshua Olson, Victor Nizet, Richard Daneman, Kelly Doran, David J. Gonzalez
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
ABSTRACT Group B Streptococcus (GBS) remains the leading cause of neonatal meningitis, a disease associated with high rates of adverse neurological sequelae. The in vivo relationship between GBS and brain tissues remains poorly characterized, partly
Externí odkaz:
https://doaj.org/article/6937f2e3052a4afdbe7d31c35a75fdc5
Autor:
Samantha J. Hindle, Roeben N. Munji, Elena Dolghih, Garrett Gaskins, Souvinh Orng, Hiroshi Ishimoto, Allison Soung, Michael DeSalvo, Toshihiro Kitamoto, Michael J. Keiser, Matthew P. Jacobson, Richard Daneman, Roland J. Bainton
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1304-1316 (2017)
Summary: Central nervous system (CNS) chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs cause CNS side-effects despite negligible transit past the BBB. To investigate th
Externí odkaz:
https://doaj.org/article/ab536355a3d44a6c8f5909e9d8116224
Autor:
Geoffrey Weiner, Sidar Aydin, Michael C. Oldham, Masakazu Kotoda, Anne Christelle Cabangcala, Richard Daneman, Roeben N. Munji, Bridgette D. Semple, Tomoki Hashimoto, Austin Batugal, Masaaki Korai, Linda J. Noble-Haeusslein, Patrick G. Schupp, Fabien Sohet, Kayleen Gimlin, Allison Soung, Alpa Trivedi
Publikováno v:
Nature neuroscience, vol 22, iss 11
Nature neuroscience
Nature neuroscience
Blood vessels in the central nervous system (CNS) form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disea
Autor:
Victor Nizet, Robert H. Mills, Roeben N. Munji, Mario Malfavon, Richard Daneman, Anaamika Campeau, Kelly S. Doran, Liwen Deng, Joshua Olson, Kaja Bajc, Marie Blanchette, David Gonzalez, Bryan Hancock, Kathryn A. Patras
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
mSystems
mSystems, Vol 5, Iss 4, p e00368-20 (2020)
mSystems, vol 5, iss 4
mSystems
mSystems, Vol 5, Iss 4, p e00368-20 (2020)
mSystems, vol 5, iss 4
Group B Streptococcus (GBS) meningitis remains a major cause of poor health outcomes very early in life. Both the host-pathogen relationship leading to disease and the massive host response to infection contributing to these poor outcomes are orchest
Publikováno v:
The Journal of Experimental Medicine
The blood vessels of the central nervous system tightly control the movement of ions, molecules, and cells between the blood and tissue. This “blood–brain barrier” is vital for neural homeostasis and protection. This review discusses current kn
Autor:
Roeben N. Munji, Richard Daneman
Publikováno v:
Nature. 583:362-363
The discovery that larger quantities of blood-borne proteins enter the brains of young, healthy mice than enter those of aged animals will alter our understanding of the blood–brain barrier, and how it changes with age. Endogenous proteins tracked
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes
Autor:
Frédéric Gachon, Mario Malfavon, Geoffrey Weiner, Koji L. Foreman, Clare R. Quirk, Sara Elmsaouri, Stefan Leutgeb, Tongcheng Qian, Caterina P. Profaci, Richard Daneman, Tamara C. Chan, Eric V. Shusta, Meghan Rossi, Michael R. Gorman, Robert S. Pulido, Marie Blanchette, Benjamin D. Weger, Aaron Deng, Roeben N. Munji
Publikováno v:
Neuron
Neuron, vol 108, iss 5
Neuron, vol 108, iss 5
The blood vessels in the central nervous system (CNS) have a series of unique properties, termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into the brain, thus maintaining proper brain homeostasis. We sought to
Autor:
Ann Easton, Joseph S. Ramahi, Roeben N. Munji, Susan C. Chapman, Rami N. Hannoush, Baouyen Tran, Linda A. Szabo, Camilla S Teng, Laura W. Burrus, Lydia Li, Rowena Suriben, Ouma Onguka, Lisa M. Galli
Publikováno v:
Developmental Dynamics. 243:833-843
Background: WNT1 and WNT3A drive a dorsal to ventral gradient of b-catenin-dependent Wnt signaling in the developing spinal cord. However, the identity of the receptors mediating downstream functions remains poorly understood. Results: In this report
Autor:
Calvin J. Kuo, Dimitrios Davalos, An-Chi Tien, Junlei Chang, Hui-Hsin Tsai, Roeben N. Munji, Jonah R. Chan, Stephen P.J. Fancy, Richard Daneman, Haijing Zhang, Jianqin Niu
Publikováno v:
Science (New York, N.Y.), vol 351, iss 6271
Neuronal migrations follow vascular pathways In the developing brain, various types of cells migrate from their birthplaces to their workplaces. Oligodendrocyte precursors, which develop to form the insulating sheaths that make signal transmission al
Autor:
Christine D. Pozniak, Trung Huynh, Samuel J. Pleasure, Abraham J. Langseth, Roeben N. Munji, Youngshik Choe
Publikováno v:
The Journal of Neuroscience. 30:13367-13372
Oligodendrocyte precursor cells (OPCs) are generated from multiple progenitor domains in the telencephalon in developmental succession from ventral to dorsal. Previous studies showed that Wnt signaling inhibits the differentiation of OPCs into mature