Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rodwell Mabaera"'
Autor:
Mohamed A. ElTanbouly, Yanding Zhao, Evelien Schaafsma, Christopher M. Burns, Rodwell Mabaera, Chao Cheng, Randolph J. Noelle
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
In recent years, the success of immunotherapy targeting immunoregulatory receptors (immune checkpoints) in cancer have generated enthusiastic support to target these receptors in a wide range of other immune related diseases. While the overwhelming f
Externí odkaz:
https://doaj.org/article/abea92dae8fd454784696491bf1265c9
Autor:
Mohamed A. ElTanbouly, Evelien Schaafsma, Nicole C. Smits, Parth Shah, Chao Cheng, Christopher Burns, Bruce R. Blazar, Randolph J. Noelle, Rodwell Mabaera
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the abi
Externí odkaz:
https://doaj.org/article/f05ea260137e48869195112b2fe2209a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-8 (2018)
Abstract Background Uveal melanoma accounts for 85% of the ocular melanomas and has an increased risk of hematogenous spread, most commonly to the liver. After curative intent therapy like surgery and radiation, fifty percent of patients present with
Externí odkaz:
https://doaj.org/article/2f50bbafae1f4d488aace80186767302
Autor:
Thomas W. K. Broughton, Mohamed A. ElTanbouly, Evelien Schaafsma, Jie Deng, Aurélien Sarde, Walburga Croteau, Jiannan Li, Elizabeth C. Nowak, Rodwell Mabaera, Nicole C. Smits, Anna Kuta, Randolph J. Noelle, J. Louise Lines
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The role of negative checkpoint regulators (NCRs) in human health and disease cannot be overstated. V-domain Ig-containing Suppressor of T-cell Activation (VISTA) is an Ig superfamily protein predominantly expressed within the hematopoietic compartme
Externí odkaz:
https://doaj.org/article/aa81c03c2d9d49e181064387b1d2ad4b
Autor:
Rodwell Mabaera, Randolph J. Noelle, David A. Leib, Chao Cheng, Frederick S. Varn, Christopher H. Lowrey, Isabelle Le Mercier, Richard Manivanh, Dov A. Pechenick, David C. Qian, Yu-Chi Lee, J. Louise Lines, Aurelien Sarde, Jiannan Li, Jie Deng
Tumor hypoxia is a negative prognostic factor that is implicated in oncogenic signal activation, immune escape, and resistance to treatment. Identifying the mechanistic role of hypoxia in immune escape and resistance to immune-checkpoint inhibitors m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949804db5e7d6c80642766b2bbbdc66e
https://doi.org/10.1158/2326-6066.c.6549897
https://doi.org/10.1158/2326-6066.c.6549897
Autor:
Rodwell Mabaera, Randolph J. Noelle, David A. Leib, Chao Cheng, Frederick S. Varn, Christopher H. Lowrey, Isabelle Le Mercier, Richard Manivanh, Dov A. Pechenick, David C. Qian, Yu-Chi Lee, J. Louise Lines, Aurelien Sarde, Jiannan Li, Jie Deng
Supplementary Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622a10c668596dce71cdf77357503f9a
https://doi.org/10.1158/2326-6066.22542372.v1
https://doi.org/10.1158/2326-6066.22542372.v1
Autor:
Rodwell Mabaera, Randolph J. Noelle, David A. Leib, Chao Cheng, Frederick S. Varn, Christopher H. Lowrey, Isabelle Le Mercier, Richard Manivanh, Dov A. Pechenick, David C. Qian, Yu-Chi Lee, J. Louise Lines, Aurelien Sarde, Jiannan Li, Jie Deng
Figure S2. Vista expression is correlated with myeloid infiltration in the TME of colon cancer patients. Volcano plot of CLS differences (granulocytic, monocytic, and αβ T cells) between VISTAhigh and VISTAlow cohorts and the associated significanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d9c19353a01304e5354684d00c0541
https://doi.org/10.1158/2326-6066.22542375.v1
https://doi.org/10.1158/2326-6066.22542375.v1
Autor:
Joaquina C Baranda, Francisco J Diaz, Larry Rubinstein, Anthony F Shields, Farshid Dayyani, Amitkumar Mehta, Janice M Mehnert, Jonathan Trent, Rodwell Mabaera, Margaret Mooney, Jeffrey A Moscow, James Doroshow, Brittany Waters, Percy Ivy, Steven D Gore, Alexandra Thomas
Publikováno v:
JNCI cancer spectrum, vol 7, iss 1
BackgroundDisparities in cancer outcomes persist for underserved populations; one important aspect of this is limited access to promising early phase clinical trials. To address this, the National Cancer Institute–funded Create Access to Targeted C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c8b904287aeee25aa6e06dd717aab0
https://escholarship.org/uc/item/5678c101
https://escholarship.org/uc/item/5678c101
Autor:
Randolph J. Noelle, Mohamed A. ElTanbouly, Chao Cheng, Evelien Schaafsma, Bruce R. Blazar, Rodwell Mabaera, Nicole C. Smits, Parth S Shah, Christopher M. Burns
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c163c7f22c5b99185fa9553eba4232c
http://europepmc.org/articles/PMC7593571
http://europepmc.org/articles/PMC7593571
Autor:
Rodwell Mabaera
Publikováno v:
JAMA Oncology. 7:1652
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb0d3644da228a419a0899b35422fa8
https://doi.org/10.1001/jamaoncol.2021.3970
https://doi.org/10.1001/jamaoncol.2021.3970