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Autor:
Spahn, V., Del Vecchio, G., Labuz, D., Rodriguez-Gaztelumendi, A., Massaly, N., Temp, J., Durmaz, V., Sabri, P., Reidelbach, M., Machelska, H., Weber, M., Stein, C.
Publikováno v:
Science, 2017 Mar 01. 355(6328), 966-969.
Externí odkaz:
https://www.jstor.org/stable/24918457
Autor:
Sara González-Rodríguez, Mohiuddin A Quadir, Shilpi Gupta, Karolina A Walker, Xuejiao Zhang, Viola Spahn, Dominika Labuz, Antonio Rodriguez-Gaztelumendi, Martin Schmelz, Jan Joseph, Maria K Parr, Halina Machelska, Rainer Haag, Christoph Stein
Publikováno v:
eLife, Vol 6 (2017)
Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synt
Externí odkaz:
https://doaj.org/article/553bd809c96a44cbbe7e18aeffc752ed
Publikováno v:
In Experimental Neurology 2010 224(1):37-47
Publikováno v:
In Neuropharmacology December 2008 55(8):1391-1396
Autor:
Daniela Laricchiuta, Maria Luisa Rojo, Antonio Rodriguez-Gaztelumendi, Fabio Ferlazzo, Laura Petrosini, Christopher J Fowler
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42111 (2012)
Typically, approach behaviour is displayed in the context of moving towards a desired goal, while avoidance behaviour is displayed in the context of moving away from threatening or novel stimuli. In the current research, we detected three sub-populat
Externí odkaz:
https://doaj.org/article/e05cefdfca8e47708c38998113fed5f6
Autor:
Antonio Rodriguez-Gaztelumendi, Halina Machelska, Christoph Stein, Dominika Labuz, Viola Spahn
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. The newly designed, pH-dependent opioid agonist NFEPP induced analgesia exclusively through peripheral opioid receptors in models of neuropathic and abdominal pain.
Recently, (±)-N-(3-fluor
Recently, (±)-N-(3-fluor
Autor:
Halina Machelska, Viola Seitz, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Marcus Weber, Michael Kloner, Roger Negrete, Dominika Labuz, Julia Temp
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Autor:
Marcus Weber, Dominika Labuz, Michael Kloner, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Roger Negrete, Viola Seitz, Halina Machelska, Julia Temp
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Autor:
Martin Schmelz, Rainer Haag, Viola Spahn, Dominika Labuz, Christoph Stein, Jan Felix Joseph, Maria Kristina Parr, Sara González-Rodríguez, Xuejiao Zhang, Mohiuddin A. Quadir, Shilpi Gupta, Halina Machelska, Karolina A Walker, Antonio Rodriguez-Gaztelumendi
Publikováno v:
eLife, Vol 6 (2017)
eLife
Gonzalez-Rodriguez, S.; Quadir, M.A.; Gupta, S.; Walker, K.A.; Zhang, X.; Spahn, V.; Labuz, D.; Rodriguez-Gaztelumendi, A.; Schmelz, M.; Joseph, J.; Parr, M.K.; Machelska, H.; Haag, R.; Stein, C. : Polyglycerol-opioid conjugate produces analgesia devoid of side effects. In: eLife. Vol. 6 (2017) e27081. (DOI: 10.7554/eLife.27081)
eLife
Gonzalez-Rodriguez, S.; Quadir, M.A.; Gupta, S.; Walker, K.A.; Zhang, X.; Spahn, V.; Labuz, D.; Rodriguez-Gaztelumendi, A.; Schmelz, M.; Joseph, J.; Parr, M.K.; Machelska, H.; Haag, R.; Stein, C. : Polyglycerol-opioid conjugate produces analgesia devoid of side effects. In: eLife. Vol. 6 (2017) e27081. (DOI: 10.7554/eLife.27081)
Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synt