Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Autor: Graff, Mariaelisa, Justice, Anne E., Young, Kristin L., Marouli, Eirini, Zhang, Xinruo, Fine, Rebecca S., Lim, Elise, Buchanan, Victoria, Rand, Kristin, Feitosa, Mary F., Wojczynski, Mary K., Yanek, Lisa R., Shao, Yaming, Rohde, Rebecca, Adeyemo, Adebowale A., Aldrich, Melinda C., Allison, Matthew A., Ambrosone, Christine B., Ambs, Stefan, Amos, Christopher, Arnett, Donna K., Atwood, Larry, Bandera, Elisa V., Bartz, Traci, Becker, Diane M., Berndt, Sonja I., Bernstein, Leslie, Bielak, Lawrence F., Blot, William J., Bottinger, Erwin P., Bowden, Donald W., Bradfield, Jonathan P., Brody, Jennifer A., Broeckel, Ulrich, Burke, Gregory, Cade, Brian E., Cai, Qiuyin, Caporaso, Neil, Carlson, Chris, Carpten, John, Casey, Graham, Chanock, Stephen J., Chen, Guanjie, Chen, Minhui, Chen, Yii-Der I., Chen, Wei-Min, Chesi, Alessandra, Chiang, Charleston W.K., Chu, Lisa, Coetzee, Gerry A., Conti, David V., Cooper, Richard S., Cushman, Mary, Demerath, Ellen, Deming, Sandra L., Dimitrov, Latchezar, Ding, Jingzhong, Diver, W. Ryan, Duan, Qing, Evans, Michele K., Falusi, Adeyinka G., Faul, Jessica D., Fornage, Myriam, Fox, Caroline, Freedman, Barry I., Garcia, Melissa, Gillanders, Elizabeth M., Goodman, Phyllis, Gottesman, Omri, Grant, Struan F.A., Guo, Xiuqing, Hakonarson, Hakon, Haritunians, Talin, Harris, Tamara B., Harris, Curtis C., Henderson, Brian E., Hennis, Anselm, Hernandez, Dena G., Hirschhorn, Joel N., McNeill, Lorna Haughton, Howard, Timothy D., Howard, Barbara, Hsing, Ann W., Hsu, Yu-Han H., Hu, Jennifer J., Huff, Chad D., Huo, Dezheng, Ingles, Sue A., Irvin, Marguerite R., John, Esther M., Johnson, Karen C., Jordan, Joanne M., Kabagambe, Edmond K., Kang, Sun J., Kardia, Sharon L., Keating, Brendan J., Kittles, Rick A., Klein, Eric A., Kolb, Suzanne, Kolonel, Laurence N., Kooperberg, Charles, Kuller, Lewis, Kutlar, Abdullah, Lange, Leslie, Langefeld, Carl D., Le Marchand, Loic, Leonard, Hampton, Lettre, Guillaume, Levin, Albert M., Li, Yun, Li, Jin, Liu, Yongmei, Liu, Youfang, Liu, Simin, Lohman, Kurt, Lotay, Vaneet, Lu, Yingchang, Maixner, William, Manson, JoAnn E., McKnight, Barbara, Meng, Yan, Monda, Keri L., Monroe, Kris, Moore, Jason H., Mosley, Thomas H., Mudgal, Poorva, Murphy, Adam B., Nadukuru, Rajiv, Nalls, Mike A., Nathanson, Katherine L., Nayak, Uma, N’Diaye, Amidou, Nemesure, Barbara, Neslund-Dudas, Christine, Neuhouser, Marian L., Nyante, Sarah, Ochs-Balcom, Heather, Ogundiran, Temidayo O., Ogunniyi, Adesola, Ojengbede, Oladosu, Okut, Hayrettin, Olopade, Olufunmilayo I., Olshan, Andrew, Padhukasahasram, Badri, Palmer, Julie, Palmer, Cameron D., Palmer, Nicholette D., Papanicolaou, George, Patel, Sanjay R., Pettaway, Curtis A., Peyser, Patricia A., Press, Michael F., Rao, D.C., Rasmussen-Torvik, Laura J., Redline, Susan, Reiner, Alex P., Rhie, Suhn K., Rodriguez-Gil, Jorge L., Rotimi, Charles N., Rotter, Jerome I., Ruiz-Narvaez, Edward A., Rybicki, Benjamin A., Salako, Babatunde, Sale, Michele M., Sanderson, Maureen, Schadt, Eric, Schreiner, Pamela J., Schurmann, Claudia, Schwartz, Ann G., Shriner, Daniel A., Signorello, Lisa B., Singleton, Andrew B., Siscovick, David S., Smith, Jennifer A., Smith, Shad, Speliotes, Elizabeth, Spitz, Margaret, Stanford, Janet L., Stevens, Victoria L., Stram, Alex, Strom, Sara S., Sucheston, Lara, Sun, Yan V., Tajuddin, Salman M., Taylor, Herman, Taylor, Kira, Tayo, Bamidele O., Thun, Michael J., Tucker, Margaret A., Vaidya, Dhananjay, Van Den Berg, David J., Vedantam, Sailaja, Vitolins, Mara, Wang, Zhaoming, Ware, Erin B., Wassertheil-Smoller, Sylvia, Weir, David R., Wiencke, John K., Williams, Scott M., Williams, L. Keoki, Wilson, James G., Witte, John S., Wrensch, Margaret, Wu, Xifeng, Yao, Jie, Zakai, Neil, Zanetti, Krista, Zemel, Babette S., Zhao, Wei, Zhao, Jing Hua, Zheng, Wei, Zhi, Degui, Zhou, Jie, Zhu, Xiaofeng, Ziegler, Regina G., Zmuda, Joe, Zonderman, Alan B., Psaty, Bruce M., Borecki, Ingrid B., Cupples, L. Adrienne, Liu, Ching-Ti, Haiman, Christopher A., Loos, Ruth, Ng, Maggie C.Y., North, Kari E.

Publikováno v: In The American Journal of Human Genetics 1 April 2021 108(4):564-582

Genome-wide scan of 29,141 African Americans finds no evidence of selection since admixture

Autor: Bhatia, Gaurav, Tandon, Arti, Aldrich, Melinda C., Ambrosone, Christine B., Amos, Christopher, Bandera, Elisa V., Berndt, Sonja I., Bernstein, Leslie, Blot, William J., Bock, Cathryn H., Caporaso, Neil, Casey, Graham, Deming, Sandra L., Diver, W. Ryan, Gapstur, Susan M., Gillanders, Elizabeth M., Harris, Curtis C., Henderson, Brian E., Ingles, Sue A., Isaacs, William, John, Esther M., Kittles, Rick A., Larkin, Emma, McNeill, Lorna H., Millikan, Robert C., Murphy, Adam, Neslund-Dudas, Christine, Nyante, Sarah, Press, Michael F., Rodriguez-Gil, Jorge L., Rybicki, Benjamin A., Schwartz, Ann G., Signorello, Lisa B., Spitz, Margaret, Strom, Sara S., Tucker, Margaret A., Wiencke, John K., Witte, John S., Wu, Xifeng, Yamamura, Yuko, Zanetti, Krista A., Zheng, Wei, Ziegler, Regina G., Chanock, Stephen J., Haiman, Christopher A., Reich, David, Price, Alkes L.

We scanned through the genomes of 29,141 African Americans, searching for loci where the average proportion of African ancestry deviates significantly from the genome-wide average. We failed to find any genome-wide significant deviations, and conclud

Externí odkaz: http://arxiv.org/abs/1312.2675

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach

Autor: Gao, Guimin, Zhao, Fangyuan, Ahearn, Thomas U, Lunetta, Kathryn L, Troester, Melissa A, Du, Zhaohui, Ogundiran, Temidayo O, Ojengbede, Oladosu, Blot, William, Nathanson, Katherine L, Domchek, Susan M, Nemesure, Barbara, Hennis, Anselm, Ambs, Stefan, McClellan, Julian, Nie, Mark, Bertrand, Kimberly, Zirpoli, Gary, Yao, Song, Olshan, Andrew F, Bensen, Jeannette T, Bandera, Elisa V, Nyante, Sarah, Conti, David V, Press, Michael F, Ingles, Sue A, John, Esther M, Bernstein, Leslie, Hu, Jennifer J, Deming-Halverson, Sandra L, Chanock, Stephen J, Ziegler, Regina G, Rodriguez-Gil, Jorge L, Sucheston-Campbell, Lara E, Sandler, Dale P, Taylor, Jack A, Kitahara, Cari M, O’Brien, Katie M, Bolla, Manjeet K, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Michailidou, Kyriaki, Pharoah, Paul D P, Wang, Qin, Figueroa, Jonine, Biritwum, Richard, Adjei, Ernest, Wiafe, Seth, Ambrosone, Christine B, Zheng, Wei, Olopade, Olufunmilayo I, García-Closas, Montserrat, Palmer, Julie R, Haiman, Christopher A, Huo, Dezheng

Publikováno v: Hum Mol Genet
Gao, G, Zhao, F, Ahearn, T U, Lunetta, K L, Troester, M A, Du, Z, Ogundiran, T O, Ojengbede, O, Blot, W, Nathanson, K L, Domchek, S M, Nemesure, B, Hennis, A, Ambs, S, Mcclellan, J, Nie, M, Bertrand, K, Zirpoli, G, Yao, S, Olshan, A F, Bensen, J T, Bandera, E V, Nyante, S, Conti, D V, Press, M F, Ingles, S A, John, E M, Bernstein, L, Hu, J J, Deming-halverson, S L, Chanock, S J, Ziegler, R G, Rodriguez-gil, J L, Sucheston-campbell, L E, Sandler, D P, Taylor, J A, Kitahara, C M, O’brien, K M, Bolla, M K, Dennis, J, Dunning, A M, Easton, D F, Michailidou, K, Pharoah, P D P, Wang, Q, Figueroa, J, Biritwum, R, Adjei, E, Wiafe, S, Ambrosone, C B, Zheng, W, Olopade, O I, García-closas, M, Palmer, J R, Haiman, C A & Huo, D 2022, ' Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry : a Cross-Ancestry Approach ', Human Molecular Genetics, vol. 31, no. 18, pp. 3133-3143 . https://doi.org/10.1093/hmg/ddac102

Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remains relatively low. We aim to develop optimal PRSs for the prediction of overall and estroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5190aabf731b674db5f93e178b8d40
https://doi.org/10.1093/hmg/ddac102

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