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Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers.

Autor: Loi P; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Schade AE; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Rodriguez CL; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Krishnan A; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Perurena N; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Nguyen VTM; Division of Cancer Biology, The Institute of Cancer Research, London, United Kingdom., Xu Y; Ludwig Center at Harvard, Boston, Massachusetts.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Watanabe M; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Davis RA; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Gardner A; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Pilla NF; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Mattioli K; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Popow O; Harvard Medical School, Boston, Massachusetts.; Dana Farber Institute, Boston, Massachusetts., Gunduz N; CRUK Beatson Institute, Glasgow, United Kingdom.; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Lannagan TRM; CRUK Beatson Institute, Glasgow, United Kingdom.; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Fitzgerald S; Harvard Medical School, Boston, Massachusetts.; Dana Farber Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Sicinska ET; Dana Farber Institute, Boston, Massachusetts., Lin JR; Ludwig Center at Harvard, Boston, Massachusetts.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Tan W; Dana Farber Institute, Boston, Massachusetts., Brais LK; Dana Farber Institute, Boston, Massachusetts., Haigis KM; Harvard Medical School, Boston, Massachusetts.; Dana Farber Institute, Boston, Massachusetts., Giannakis M; Harvard Medical School, Boston, Massachusetts.; Dana Farber Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Ng K; Dana Farber Institute, Boston, Massachusetts., Santagata S; Ludwig Center at Harvard, Boston, Massachusetts.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Helin K; Division of Cancer Biology, The Institute of Cancer Research, London, United Kingdom., Sansom OJ; CRUK Beatson Institute, Glasgow, United Kingdom.; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Cichowski K; Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Dec 02; Vol. 14 (12), pp. 2430-2449.