Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes.

Autor: de Aquino TM; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil | Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-900, Maceió-AL, Brazil., França PHB; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Rodrigues ÉEES; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Nascimento IJS; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Santos-Júnior PFS; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Aquino PGV; Chemistry Institute, Federal Rural University of Pernambuco, Garanhuns-PE 55292-270, Brazil., Santos MS; Chemistry Institute, Federal Rural University of Pernambuco, Garanhuns-PE 55292-270, Brazil., Queiroz AC; Laboratory of Pharmacology and Immunology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil | Laboratory of Microbiology, Immunology and Parasitology, Medical Science Center, Campus Arapiraca, Federal University of Alagoas, Arapiraca-AL 57309-005, Brazil., Araújo MV; Laboratory of Pharmacology and Immunology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Alexandre-Moreira MS; Laboratory of Pharmacology and Immunology, Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil., Rodrigues RRL; Laboratory of Infectious Diseases, Federal University of Parnaíba Delta, Parnaíba-PI 64202-020, Brazil., Rodrigues KAF; Laboratory of Infectious Diseases, Federal University of Parnaíba Delta, Parnaíba-PI 64202-020, Brazil., Freitas JD; Instrumental Analysis Laboratory, Federal Institute of Alagoas, Campus Maceió, Ferroviário Avenue, Maceió-AL 57020-600, Brazil., Bricard J; Laboratoire d\'Innovation thérapeutique, Labex Medalis, UMR 7200, CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, BP 60024, Illkirch 67401, France., Meneghetti MR; Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-900, Maceió-AL, Brazil., Bourguignon JJ; Laboratoire d\'Innovation thérapeutique, Labex Medalis, UMR 7200, CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, BP 60024, Illkirch 67401, France., Schmitt M; Laboratoire d\'Innovation thérapeutique, Labex Medalis, UMR 7200, CNRS, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, BP 60024, Illkirch 67401, France., da Silva-Júnior EF; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil | Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-900, Maceió-AL, Brazil., de Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió-AL 57072-900, Brazil.

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2022; Vol. 18 (2), pp. 151-169.