Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Rodrigues AD"'
Autor:
Rodrigues Ad
Publikováno v:
Biochemical Pharmacology. 57:465-480
With the increased availability of human liver tissue, recombinant (cDNA-expressed) cytochrome P450 proteins (rCYPs), and knowledge of the human CYP pool (e.g. immunoquantitated levels of each CYP form in native liver microsomes), it is now possible
Autor:
Rodrigues Ad
Publikováno v:
Biochemical Pharmacology. 48:2147-2156
Autor:
Varma, MV, El‐Kattan, AF, Feng, B, Steyn, SJ, Maurer, TS, Scott, DO, Rodrigues, AD, Tremaine, LM
Publikováno v:
Clinical Pharmacology & Therapeutics; Jul2017, Vol. 102 Issue 1, p33-36, 4p
Autor:
Varma, MV, Kimoto, E, Scialis, R, Bi, Y, Lin, J, Eng, H, Kalgutkar, AS, El‐Kattan, AF, Rodrigues, AD, Tremaine, LM
Publikováno v:
Clinical Pharmacology & Therapeutics; Mar2017, Vol. 101 Issue 3, p406-415, 10p
Autor:
Cuyue Tang, De Schepper Pj, Gelmann A, Woolf Ej, De Lepeleire I, Sandhu P, Greenberg He, Schwartz Ji, Rose Mj, Van Hecken A, Qin Mei, Rodrigues Ad, Rushmore Th, Shou M, Ebel Dl
Publikováno v:
Pharmacogenetics. 11(3)
In-vitro studies were conducted to assess the impact of CYP2C9 genotype on the metabolism (methyl hydroxylation) and pharmacokinetics of celecoxib, a novel cyclooxygenase-2 inhibitor and CYP2C9 substrate. When compared to cDNA-expressed wild-type CYP
Autor:
Wong Sl, Rodrigues Ad
Publisher Summary It is now known that most of the drug-metabolizing enzyme (DME) systems present in the human liver, for example, cytochrome P450, CYP; UDP-glucuronosyltransferase, UDPGT; Nacetyltransferase, NAT; and NADPH-dependent flavin-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f8bc88432fecf991ace452becd6ce5
https://doi.org/10.1016/s1054-3589(08)60202-1
https://doi.org/10.1016/s1054-3589(08)60202-1
Autor:
Machinist Jm, Rodrigues Ad
Publikováno v:
Toxicology and applied pharmacology. 137(2)
The effects of zileuton, a 5-lipoxygenase inhibitor, on hepatic peroxisomal enzyme activity as well as hepatic drug metabolizing activity in male and female CD-1 mice were assessed after oral administration of the drug (50, 150, or 450 mg/kg/day) for
Autor:
Rodrigues Ad
Publisher Summary This chapter describes a simple, rapid, and sensitive assay procedure for measuring CYP2D6-dependent monooxygenase activity in human liver microsomes employing [O-methyl- 14 C]dextromethorphan as substrate. The assay involves the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b0bf163ed5dd08004de4b2e9fd0bf3
https://doi.org/10.1016/s0076-6879(96)72023-2
https://doi.org/10.1016/s0076-6879(96)72023-2
Publikováno v:
Chemical research in toxicology. 4(3)
The efficacy of 3-tert-butyl-4-hydroxyanisole (BHA) as a chemopreventive agent against chemically induced cancer or toxicity may involve the direct modulation of cytochrome P-450 dependent monooxygenase function. This hypothesis was investigated by u
Autor:
Eley, T, Han, Y‐H, Huang, S‐P, He, B, Li, W, Bedford, W, Stonier, M, Gardiner, D, Sims, K, Rodrigues, AD, Bertz, RJ
Publikováno v:
Clinical Pharmacology & Therapeutics; Feb2015, Vol. 97 Issue 2, p159-166, 8p