Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity

Autor: Allen-Redpath, K, Aldrovandi, M, Lauder, SN, Gketsopoulou, A, Tyrrell, VJ, Slatter, DA, Andrews, R, Watkins, WJ, Atkinson, G, McNeill, E, Gilfedder, A, Protty, M, Burston, J, Johnson, SRC, Rodrigues, PRS, Jones, DO, Lee, R, Handa, A, Channon, K, Obaji, S, Alvarez-Jarreta, J, Krönke, G, Ackermann, J, Jenkins, PV, Collins, PW, O'Donnell, VB

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Abdominal aortic aneurysm (AAA) is a disease of the abdominal aorta where inflammation causes damage and can ultimately lead to rupture. When this happens, uncontrolled internal bleeding can lead to death within minutes. Many aneurysms a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c578070775aca45439d10f8ed4410bfa
https://ora.ox.ac.uk/objects/uuid:9a217d97-a4d3-4fa5-9ce7-63b306358451

Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.

Autor: Sharma S; Project Sepsis, Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK; Department of Obstetrics & Gynaecology, University Hospital of Wales, Cardiff, CF14 4XW, UK. Electronic address: SharmaS44@cardiff.ac.uk., Rodrigues PRS; Project Sepsis, Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK., Zaher S; Project Sepsis, Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK; Department of Obstetrics & Gynaecology, University Hospital of Wales, Cardiff, CF14 4XW, UK., Davies LC; Project Sepsis, Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK; Biomedical Sciences Unit, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK., Ghazal P; Project Sepsis, Systems Immunity Research Institute, Cardiff University, Cardiff, CF14 4XN, UK. Electronic address: ghazalp@cardiff.ac.uk.

Publikováno v: EBioMedicine [EBioMedicine] 2022 Dec; Vol. 86, pp. 104337. Date of Electronic Publication: 2022 Dec 02.

mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health - a prospective observational cohort study protocol.

Autor: Sharma S; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK SharmaS44@cardiff.ac.uk.; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK., Zaher S; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK.; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK., Rodrigues PRS; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Davies LC; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Edkins S; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Strang A; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Chakraborty M; Regional Neonatal Intensive Care Unit, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK., Watkins WJ; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK., Andrews R; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Parkinson E; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Angelopoulos N; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Moet L; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Shepherd F; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Davies KMM; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., White D; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Oram S; Department of Anaesthesia and Critical Care, University Hospital of Wales, Cardiff, UK., Siddall K; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK., Keeping V; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK., Simpson K; Department of Anaesthesia and Critical Care, University Hospital of Wales, Cardiff, UK., Faggian F; Department of Microbiology, University Hospital of Wales, Cardiff, UK., Bray M; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK., Bertorelli C; Department of Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK., Bell S; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Department of Anaesthesia and Critical Care, University of Wales Cardiff, Cardiff, UK., Collis RE; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Department of Anaesthetics, Intensive Care and Pain Medicine, Cardiff and Vale University Health Board, Cardiff, UK., McLaren JE; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Labeta M; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., O'Donnell VB; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK., Ghazal P; Project Sepsis, Systems Immunity Research Institute, Cardiff University Cardiff Institute of Infection and Immunity, Cardiff, UK.; Cardiff Division of Infection and Immunity, Cardiff University, Cardiff, UK.

Publikováno v: BMJ open [BMJ Open] 2022 Sep 17; Vol. 12 (9), pp. e066382. Date of Electronic Publication: 2022 Sep 17.

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.

Autor: Misheva M; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Kotzamanis K; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Davies LC; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Tyrrell VJ; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Rodrigues PRS; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Benavides GA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Hinz C; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Murphy RC; Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045, USA., Kennedy P; Cayman Chemical, 1180 E Ellsworth Rd, Ann Arbor, MI, 48108, USA., Taylor PR; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, CF14 4XN, Cardiff, UK., Rosas M; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Jones SA; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., McLaren JE; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Deshpande S; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Andrews R; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gausstraße 20, 42119, Wuppertal, Germany., Czubala MA; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Gurney M; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Aldrovandi M; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Meckelmann SW; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Ghazal P; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK., Darley-Usmar V; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., White DA; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK. WhiteD13@cardiff.ac.uk., O'Donnell VB; Systems Immunity Research Institute and Division of Infection and Immunity, and School of Medicine, Cardiff University, CF14 4XN, Cardiff, UK. o-donnellvb@cardiff.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 10; Vol. 13 (1), pp. 139. Date of Electronic Publication: 2022 Jan 10.

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications.

Autor: Alvarez-Jarreta J; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK., Rodrigues PRS; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Fahy E; Department of Bioengineering, University of California, San Diego, CA 92037, USA., O'Connor A; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Price A; School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK., Gaud C; Bioinformatics, Babraham Institute, Cambridge CF24 3AA, UK., Andrews S; Bioinformatics, Babraham Institute, Cambridge CF24 3AA, UK., Benton P; The Scripps Research Institute, Center for Metabolomics, La Jolla, CA 92037, USA., Siuzdak G; The Scripps Research Institute, Center for Metabolomics, La Jolla, CA 92037, USA., Hawksworth JI; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Valdivia-Garcia M; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Allen SM; School of Computer Science and Informatics, Cardiff University, Cardiff CF24 3AA, UK., O'Donnell VB; School of Medicine, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2021 Jun 16; Vol. 37 (10), pp. 1478-1479.