Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Rodrigo S, Lacruz"'
Autor:
Timothy G Bromage, Youssef Idaghdour, Rodrigo S Lacruz, Thomas D Crenshaw, Olexandra Ovsiy, Björn Rotter, Klaus Hoffmeier, Friedemann Schrenk
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301870 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0145919.].
Externí odkaz:
https://doaj.org/article/4a97ce892b544feba6f17557ba532af6
Autor:
Caterina Vianello, Federica Dal Bello, Sang Hun Shin, Sara Schiavon, Camilla Bean, Ana Paula Magalhães Rebelo, Tomáš Knedlík, Emad Norouzi Esfahani, Veronica Costiniti, Rodrigo S. Lacruz, Giuseppina Covello, Fabio Munari, Tommaso Scolaro, Antonella Viola, Elena Rampazzo, Luca Persano, Sara Zumerle, Luca Scorrano, Alessio Gianelle, Marta Giacomello
Publikováno v:
Cells, Vol 12, Iss 7, p 1089 (2023)
Recent proteomic, metabolomic, and transcriptomic studies have highlighted a connection between changes in mitochondria physiology and cellular pathophysiological mechanisms. Secondary assays to assess the function of these organelles appear fundamen
Externí odkaz:
https://doaj.org/article/62fe1550f87e4a5f8eb7dafcbe2587f7
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-13 (2021)
Abstract Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca2+) channels to treat hypertension when used at nanomolar dosage. More recently, its therapeutic application in hypertension has dec
Externí odkaz:
https://doaj.org/article/2fa6e7e6c82446bb83ef4585923e51e0
Autor:
Yi Li, Veronica Costiniti, Guilherme H. Souza Bomfim, Maria Neginskaya, Ga-Yeon Son, Beverly Rothermel, Evgeny Pavlov, Rodrigo S. Lacruz
Publikováno v:
Cells, Vol 11, Iss 22, p 3576 (2022)
The regulator of calcineurin (RCAN1) has been implicated in the pathogenesis of Down syndrome (DS). Individuals with DS show dental abnormalities for unknown reasons, and RCAN1 levels have been found to be elevated in several tissues of DS patients.
Externí odkaz:
https://doaj.org/article/a8150b60c2be40d9909a66c099bf16bb
Autor:
Veronica Costiniti, Guilherme H. Bomfim, Erna Mitaishvili, Ga-Yeon Son, Yi Li, Rodrigo S. Lacruz
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Most cells use calcium (Ca2+) as a second messenger to convey signals that affect a multitude of biological processes. The ability of Ca2+ to bind to proteins to alter their charge and conformation is essential to achieve its signaling role. Cytosoli
Externí odkaz:
https://doaj.org/article/4e330f6e3d2440d491451eca4cb73286
Autor:
Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and fol
Externí odkaz:
https://doaj.org/article/0300d7db026b4d60913b2983240f24ef
Publikováno v:
Cells, Vol 11, Iss 7, p 1190 (2022)
Plasma membrane protein channels provide a passageway for ions to access the intracellular milieu. Rapid entry of calcium ions into cells is controlled mostly by ion channels, while Ca2+-ATPases and Ca2+ exchangers ensure that cytosolic Ca2+ levels (
Externí odkaz:
https://doaj.org/article/aca5630d090d4687b76c497da615472a
Publikováno v:
American Journal of Biological Anthropology. 180:352-369
Autor:
Veronica Costiniti, Guilherme H. Bomfim, Yi Li, Erna Mitaishvili, Zhi-wei Ye, Jie Zhang, Danyelle M. Townsend, Marta Giacomello, Rodrigo S. Lacruz
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Enamel is the most calcified tissue in vertebrates. Enamel formation and mineralization is a two-step process that is mediated by ameloblast cells during their secretory and maturation stages. In these two stages, ameloblasts are characterized by dif
Externí odkaz:
https://doaj.org/article/1bb1899ecd644d48b2770a8f7d276569
Autor:
Martin Vaeth, Jun Yang, Megumi Yamashita, Isabelle Zee, Miriam Eckstein, Camille Knosp, Ulrike Kaufmann, Peter Karoly Jani, Rodrigo S. Lacruz, Veit Flockerzi, Imre Kacskovics, Murali Prakriya, Stefan Feske
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC chann
Externí odkaz:
https://doaj.org/article/cecf348141a04e5d97c610a4720fbbd4