Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice

Autor: Felipe S. Arruda, Fernanda D. Tomé, Anália C. Milhomem, Pablo I. R. Franco, Allisson B. Justino, Rodrigo R. Franco, Erica C. Campos, Foued S. Espindola, Danilo F. Soave, Mara Rubia N. Celes

Publikováno v: Pharmaceutics, Vol 16, Iss 8, p 1105 (2024)

Doxorubicin (DOX) is a potent chemotherapeutic agent used to treat multiple types of cancer, but its clinical application is limited by cardiotoxicity, mainly due to oxidative stress. Curcumin (CUR) is a natural polyphenolic compound with strong anti

Externí odkaz: https://doaj.org/article/f06e5785c64043899ed4c7f1aaffdfa1

Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells.

Autor: Tragkola V; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus., Anestopoulos I; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus., Kyriakou S; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus., Amery T; Watercress Company, Dorchester, UK., Franco R; School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA., Pappa A; Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece., Panayiotidis MI; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.

Publikováno v: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 Nov; Vol. 34 (9), pp. 985-999. Date of Electronic Publication: 2024 Jun 25.

Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its N -Acetylated Cysteine Conjugated form in Malignant Melanoma.

Autor: Kyriakou S; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus., Demosthenous N; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus., Amery T; The Watercress Company, Dorchester DT2 8QY, UK., Stewart KJ; Watercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK., Winyard PG; Watercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK., Franco R; Redox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Department of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Pappa A; Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece., Panayiotidis MI; Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Jan 08; Vol. 13 (1). Date of Electronic Publication: 2024 Jan 08.

A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge.

Autor: Pattnaik A; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Sahoo BR; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Struble LR; The Eppley Institute for Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Borgstahl GEO; The Eppley Institute for Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Zhou Y; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Franco R; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Barletta RG; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Osorio FA; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Petro TM; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Department of Oral Biology, University of Nebraska Medical Center, Lincoln, NE 68583, USA., Pattnaik AK; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2023 Apr 10; Vol. 11 (4). Date of Electronic Publication: 2023 Apr 10.

Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites.

Autor: Sahoo BR; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Crook AA; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Pattnaik A; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Torres-Gerena AD; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Khalimonchuk O; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Powers R; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for Integrated Biomolecular Communication, Lincoln, Nebraska, USA., Franco R; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Pattnaik AK; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Publikováno v: Journal of virology [J Virol] 2023 Feb 28; Vol. 97 (2), pp. e0136322. Date of Electronic Publication: 2023 Jan 23.