Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rodrigo Moraga‐Amaro"'
Autor:
Rodrigo Moraga-Amaro, Daniel Aaron Vazquez-Matias, Luiza Reali Nazario, Rudi A.J.O. Dierckx, Jimmy Stehberg, Janine Doorduin, Erik F.J. de Vries
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106727- (2024)
Most pharmacological treatments for depression target monoamine transporters and about 50 % of treated patients attain symptomatic remission. Once remission is attained, it is hard to distinguish the changes on brain monoaminergic transmission induce
Externí odkaz:
https://doaj.org/article/12ec4986401648ffb9086986c621f35a
Autor:
Rodrigo Moraga-Amaro, Cyprien G. J. Guerrin, Luiza Reali Nazario, Bruno Lima Giacobbo, Rudi A. J. O. Dierckx, Jimmy Stehberg, Erik F. J. de Vries, Janine Doorduin
Publikováno v:
Stress, Vol 25, Iss 1, Pp 145-155 (2022)
Worldwide, millions of people suffer from treatment-resistant depression. Ketamine, a glutamatergic receptor antagonist, can have a rapid antidepressant effect even in treatment-resistant patients. A proposed mechanism for the antidepressant effect o
Externí odkaz:
https://doaj.org/article/54be6d66690f44e78b6a1ee5fbc7ed8f
Autor:
Maxs Méndez-Ruette, Sergio Linsambarth, Rodrigo Moraga-Amaro, Daisy Quintana-Donoso, Luis Méndez, Giovanni Tamburini, Francisca Cornejo, Rodrigo F. Torres, Jimmy Stehberg
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The human insula has been consistently reported to be overactivated in all anxiety disorders, activation which has been suggested to be proportional to the level of anxiety and shown to decrease with effective anxiolytic treatment. Nonetheless, studi
Externí odkaz:
https://doaj.org/article/b0530154c0be457db5636c9281783935
Autor:
Kavya Prasad, Erik F. J. de Vries, Jürgen W. A. Sijbesma, Lara Garcia-Varela, Daniel A. Vazquez-Matias, Rodrigo Moraga-Amaro, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Aren van Waarde
Publikováno v:
Molecular pharmaceutics, 19(8), 2992-3001. AMER CHEMICAL SOC INC
Adenosine A2A and dopamine D2 receptors in the basal ganglia form heterotetrameric structures that are involved in the regulation of motor activity and neuropsychiatric functions. The present study examines the A2A receptor-mediated modulation of D2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab08b4c959435f79047e26315c4279d
https://research.rug.nl/en/publications/6b52f1a8-7c74-4b9f-a788-da6f621975fb
https://research.rug.nl/en/publications/6b52f1a8-7c74-4b9f-a788-da6f621975fb
Autor:
Lara García-Varela, Rodrigo Moraga-Amaro, Gert Luurtsema, Aren van Waarde, Manuel Rodríguez-Pérez, Pablo Aguiar, Rudi Dierckx, Antía Custodia, Philip H. Elsinga, Tomás Sobrino, Nicola Antonio Colabufo
Publikováno v:
Molecular Pharmaceutics
Molecular pharmaceutics, 18(8), 3073-3085. AMER CHEMICAL SOC INC
Molecular pharmaceutics, 18(8), 3073-3085. AMER CHEMICAL SOC INC
P-Glycoprotein (P-gp) is an efflux pump located at the blood-brain barrier (BBB) that contributes to the protection of the central nervous system by transporting neurotoxic compounds out of the brain. A decline in P-gp function has been related to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585ecbf7a9244c6fc7c770fbe1088c17
https://doi.org/10.1021/acs.molpharmaceut.1c00302
https://doi.org/10.1021/acs.molpharmaceut.1c00302
Autor:
Erik F. J. de Vries, Rudi Dierckx, Anna Schildt, Antoon T.M. Willemsen, Jurgen W. A. Sijbesma, Vesna Sossi, Rodrigo Moraga-Amaro, Bruno Lima-Giacobbo, Janine Doorduin
Publikováno v:
Molecular Imaging and Biology, 22(4), 931-939. SPRINGER
Purpose: [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the vesicular acetylcholine transporter (VAChT), a marker of the cholinergic system. We evaluated the quantification of [18F]FEOBV in rats in control conditions and after part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63913b3984ed26ed4c6c707b865982b4
https://doi.org/10.1007/s11307-019-01466-8
https://doi.org/10.1007/s11307-019-01466-8
Autor:
Anna Schildt, Erik F. J. de Vries, Elke Bromberg, Bruno Lima Giacobbo, Janine Doorduin, Luiza Reali Nazario, Rodrigo Moraga-Amaro, Rudi Dierckx
Publikováno v:
Psychopharmacology
Psychopharmacology, 237(6), 1595-1606. SPRINGER
Psychopharmacology, 237(6), 1595-1606. SPRINGER
Introduction Depression is characterized by behavioral, cognitive and physiological changes, imposing a major burden on the overall wellbeing of the patient. Some evidence indicates that social stress, changes in growth factors (e.g., brain-derived n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0704cdd5d94e99f42c46878fb531497
https://hdl.handle.net/11370/4f57e1ad-77f2-4bab-a22c-8235481f597e
https://hdl.handle.net/11370/4f57e1ad-77f2-4bab-a22c-8235481f597e
Autor:
Aren van Waarde, Jurgen W. A. Sijbesma, Antoon T. M. Willemsen, Erik F. J. de Vries, Vesna Sossi, Janine Doorduin, Anna Schildt, Rodrigo Moraga-Amaro, Bruno Lima Giacobbo, Rudi Dierckx
Publikováno v:
Molecular pharmaceutics, 17(3), 865-872. AMER CHEMICAL SOC INC
Molecular Pharmaceutics
Molecular Pharmaceutics
The interaction of dopaminergic and cholinergic neurotransmission in, e.g., Parkinson's disease has been well established. Here, D2 receptor antagonists were used to assess changes in [18F]-FEOBV binding to the vesicular acetylcholine transporter (VA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971ddf5f0fbf079fd12ed18375790990
https://doi.org/10.1021/acs.molpharmaceut.9b01129
https://doi.org/10.1021/acs.molpharmaceut.9b01129
Autor:
Rodrigo Moraga-Amaro, Paula Muñoz, Tomás Villalobos, Sergio Linsambarth, Francisco Maldonado, Valeria Meirone, Bruno Femopase, Jimmy Stehberg
Publikováno v:
Psychiatry Research. 320:115036
Activation of the insula is found in all anxiety-related disorders and increased insular-prefrontal cortex (PFC) functional connectivity is associated with reduced anxiety. In this study, the combined stimulation of the insula and PFC using the dTMS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8e0aa48073da0aa38f4c3b766e8a88
https://doi.org/10.1016/j.psychres.2022.115036
https://doi.org/10.1016/j.psychres.2022.115036
Autor:
Sergio Linsambarth, Francisco J. Carvajal, Rodrigo Moraga‐Amaro, Luis Mendez, Giovanni Tamburini, Ivanka Jimenez, Daniel Antonio Verdugo, Gonzalo I. Gómez, Nur Jury, Pablo Martínez, Brigitte Zundert, Lorena Varela‐Nallar, Mauricio A. Retamal, Claire Martin, Guillermo A. Altenberg, Mariana C. Fiori, Waldo Cerpa, Juan A. Orellana, Jimmy Stehberg
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(2)
Astrocytes release gliotransmitters via connexin 43 (Cx43) hemichannels into neighboring synapses, which can modulate synaptic activity and are necessary for fear memory consolidation. However, the gliotransmitters released, and their mechanisms of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7838b0514432db32cadce51904a342e3
https://pubmed.ncbi.nlm.nih.gov/35061296
https://pubmed.ncbi.nlm.nih.gov/35061296