Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rodrigo Matus Nicodemos"'
Autor:
Ahmed S. Fahad, Cheng Yu Chung, Sheila N. López Acevedo, Nicoleen Boyle, Bharat Madan, Matías F. Gutiérrez-González, Rodrigo Matus-Nicodemos, Amy D. Laflin, Rukmini R. Ladi, John Zhou, Jacy Wolfe, Sian Llewellyn-Lacey, Richard A. Koup, Daniel C. Douek, Henry H. Balfour, David A. Price, Brandon J. DeKosky
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective human T cell receptors
Externí odkaz:
https://doaj.org/article/eeee0fb53a204636b7baa68d6140de84
Autor:
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sékaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Externí odkaz:
https://doaj.org/article/1a92cd130be447828fcd995ae89a3b10
Autor:
Steven A. Rosenberg, Jessica S. Crystal, Katarzyna Trebska-McGowan, Jared Gartner, Maria R. Parkhurst, Harlan Robins, Bryan Howie, Daniel C. Douek, Rodrigo Matus-Nicodemos, Todd D. Prickett, Drew C. Deniger, Paul F. Robbins, Alena Gros, Anna Pasetto
Gating strategy, Shannon entropy, PD-1 expression, additional co-culture data, primers sequence, Frequency of the top 10 CD8+PD-1+ TCRB in bulk unsorted TIL and sorted TIL subsets, Retrospective analysis of pairing the most frequent TCRB in the CD8+P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18367889110460b48bb9bc005e4ef135
https://doi.org/10.1158/2326-6066.22537856.v1
https://doi.org/10.1158/2326-6066.22537856.v1
Autor:
Steven A. Rosenberg, Jessica S. Crystal, Katarzyna Trebska-McGowan, Jared Gartner, Maria R. Parkhurst, Harlan Robins, Bryan Howie, Daniel C. Douek, Rodrigo Matus-Nicodemos, Todd D. Prickett, Drew C. Deniger, Paul F. Robbins, Alena Gros, Anna Pasetto
Adoptive transfer of T cells with engineered T-cell receptor (TCR) genes that target tumor-specific antigens can mediate cancer regression. Accumulating evidence suggests that the clinical success of many immunotherapies is mediated by T cells target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f756e67c9f5eec0686a55a42d7f64c
https://doi.org/10.1158/2326-6066.c.6548573.v1
https://doi.org/10.1158/2326-6066.c.6548573.v1
Autor:
Krystelle Nganou-Makamdop, James M Billingsley, Zachary Yaffe, Gregory O'Connor, Gregory K Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M Robertson, Mandy L Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E Bosinger, Daniel C Douek
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007246 (2018)
Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administra
Externí odkaz:
https://doaj.org/article/222e9d607de04416ad02ccb59781e2f1
Autor:
Bitha Narayanan, Diego Prado De Maio, James LaPorta, Yekaterina Voskoboynik, Rodrigo Matus-Nicodemos, Sean Summers, Usha Ganapathi, Anibal Valentin-Acevedo, Lori R. Covey
Our previous work found that the RNA binding protein polypyrimidine tract-binding protein (PTBP1) is critical for regulating multiple events in T cell activation including changes in proliferation, and expression of activation markers and cytokines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359c97ac390325e4543515eb4126ab24
https://doi.org/10.1101/2022.03.21.485057
https://doi.org/10.1101/2022.03.21.485057
Autor:
Ahmed S Fahad, Cheng-Yu Chung, Sheila N Lopez Acevedo, Nicoleen Boyle, Bharat Madan, Matias F Gutiérrez-González, Rodrigo Matus-Nicodemos, Amy D Laflin, Rukmini R Ladi, John Zhou, Jacy Wolfe, Sian Llewellyn-Lacey, Richard A Koup, Daniel C Douek, Henry H Balfour Jr, David A Price, Brandon J DeKosky
Publikováno v:
Protein Eng Des Sel
Functional analyses of the T cell receptor (TCR) landscape can reveal critical information about protection from disease and molecular responses to vaccines. However, it has proven difficult to combine advanced next-generation sequencing technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c06b4d41bad58dde16f6e72aebfc5fb
https://europepmc.org/articles/PMC9005053/
https://europepmc.org/articles/PMC9005053/
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0158708 (2016)
We have previously shown that the RNA binding protein, polypyrimidine tract-binding protein (PTBP1) plays a critical role in regulating the expression of CD40L in activated CD4 T cells. This is achieved mechanistically through message stabilization a
Externí odkaz:
https://doaj.org/article/569f786ca9464f9aa5ef868e174418fc
Autor:
J. Zhou, D. Doueck, R. R. Ladi, Bharat Madan, Jacy R. Wolfe, N. Boyle, C. Yu Chung, David Price, S. N. Lopez Acevedo, Sian Llewellyn-Lacey, Rodrigo Matus-Nicodemos, A. S. Fahad, Amy D. Laflin, H. H. Balfour, Brandon J. DeKosky, Matias Gutiérrez-González
Functional analyses of the T cell receptor (TCR) landscape can reveal critical information about protection from disease and molecular responses to vaccines. However, it has proven difficult to combine advanced next-generation sequencing technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0112137bee9700696c19aab0e78ec5
https://doi.org/10.1101/2021.10.19.465057
https://doi.org/10.1101/2021.10.19.465057
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco