Výsledky vyhledávání - "Rodrigo Manuel Paz"

D1 / D5 Inverse Agonists Restore Striatal Cholinergic Interneuron Physiology in Dyskinetic Mice

Autor: Rodrigo Manuel Paz, Agostina Mónica Stahl, Lorena Rela, Mario Gustavo Murer, Cecilia Tubert

Publikováno v: Movement Disorders. 37:1693-1706

In advanced stages of Parkinson's disease (PD), dyskinesia and motor fluctuations become seriously debilitating and therapeutic options become scarce. Aberrant activity of striatal cholinergic interneurons (SCIN) has been shown to be critical to PD a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353a4f3d03c967510c13409ae36e57e9
https://doi.org/10.1002/mds.29055

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Levodopa Causes Striatal Cholinergic Interneuron Burst‐Pause Activity in Parkinsonian Mice

Autor: Mario Gustavo Murer, Rodrigo Manuel Paz, Yimy Amarillo, Agostina Monica Stahl, Lorena Rela, Cecilia Tubert

Publikováno v: Movement Disorders. 36:1578-1591

Background Enhanced striatal cholinergic interneuron activity contributes to the striatal hypercholinergic state in Parkinson's disease (PD) and to levodopa-induced dyskinesia. In severe PD, dyskinesia and motor fluctuations become seriously debilita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1ed9af9ff350abdff20184dd7463ad
https://doi.org/10.1002/mds.28516

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Mechanisms of Antiparkinsonian Anticholinergic Therapy Revisited

Autor: Mario Gustavo Murer, Rodrigo Manuel Paz

Publikováno v: Neuroscience. 467

Before the advent of L-DOPA, the gold standard symptomatic therapy for Parkinson's disease (PD), anticholinergic drugs (muscarinic receptor antagonists) were the preferred antiparkinsonian therapy, but their unwanted side effects associated with impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e955b94ccc58a226b923a7d6065294e
https://pubmed.ncbi.nlm.nih.gov/34048797

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Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L‐DOPA in a mouse model of Parkinson's disease

Autor: Ettel Keifman, Rosario Moratalla, Rodrigo Manuel Paz, Diego E. Pafundo, Irene Ruiz-DeDiego, Mario Gustavo Murer, Oscar Solís

Publikováno v: Br J Pharmacol
Digital.CSIC. Repositorio Institucional del CSIC
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CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

BACKGROUND AND PURPOSE: L-DOPA-induced dyskinesia (LID) remains a major complication of L-DOPA therapy in Parkinson's disease. LID is believed to result from inhibition of substantia nigra reticulata (SNr) neurons by GABAergic striatal projection neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795aa77bd4c01078333c94945e0470ff
Wiley Online Library

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Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac

Autor: Roberto Etchenique, Mario Gustavo Murer, Rodrigo Manuel Paz, Cecilia Tubert, Agostina Monica Stahl, Lorena Rela, Analía Valeria López Díaz

Striatal cholinergic interneurons provide modulation to striatal circuits involved in voluntary motor control and goal-directed behaviors through their autonomous tonic discharge and their firing “pause” responses to novel and rewarding environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46037c0479c72db3be563f568469281f
https://www.sciencedirect.com/science/article/pii/S002839081830220X

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