Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Rodrigo Ledesma- Amaro"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Microorganisms can be engineered to sustainably produce a variety of products including fuels, pharmaceuticals, materials, and food. However, highly engineered strains often result in low production yield, due to undesired effects such as me
Externí odkaz:
https://doaj.org/article/2753e359a1e346ab9a1bafc4fd42673f
Autor:
Wenwen Yu, Ke Jin, Dandan Wang, Nankai Wang, Yangyang Li, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There is a growing interest in the creation of engineered condensates formed via liquid–liquid phase separation (LLPS) to exert precise cellular control in prokaryotes. However, de novo design of cellular condensates to control metabolic f
Externí odkaz:
https://doaj.org/article/eeca9776e7854aaf8af0c0f3900be585
Publikováno v:
Synthetic and Systems Biotechnology, Vol 10, Iss 1, Pp 165-173 (2025)
Abscisic acid (ABA) is an important phytohormone with diverse applications. It currently relies on the fermentation of Botrytis cinerea, which suffers from limited availability of genetic engineering tools. Here, Yarrowia lipolytica was engineered to
Externí odkaz:
https://doaj.org/article/2b30b78b8bfb4ecf82b50f9fe4d160b9
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Conse
Externí odkaz:
https://doaj.org/article/b8ffe89328154004ba49d6bab200c00e
Autor:
Kiyan Shabestary, Cinzia Klemm, Benedict Carling, James Marshall, Juline Savigny, Marko Storch, Rodrigo Ledesma-Amaro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract In their natural environments, microorganisms mainly operate at suboptimal growth conditions with fluctuations in nutrient abundance. The resulting cellular adaptation is subject to conflicting tasks: growth or survival maximisation. Here, w
Externí odkaz:
https://doaj.org/article/86cb7d2efd3945909ec561f77dbc40c7
Autor:
Young-Kyoung Park, Lara Sellés Vidal, David Bell, Jure Zabret, Mladen Soldat, Martin Kavšček, Rodrigo Ledesma-Amaro
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background Limonene has a variety of applications in the foods, cosmetics, pharmaceuticals, biomaterials, and biofuels industries. In order to meet the growing demand for sustainable production of limonene at industry scale, it is essential
Externí odkaz:
https://doaj.org/article/d0342f782b0f407da47fa85e366a168b
Autor:
Shirin Bamezai, Giovanni Maresca di Serracapriola, Freya Morris, Rasmus Hildebrandt, Marc Augustine Sojerido Amil, Sporadicate iGEM Team, Rodrigo Ledesma‐Amaro
Publikováno v:
Engineering Biology, Vol 7, Iss 1-4, Pp 29-38 (2023)
Abstract The field of protein engineering has seen tremendous expansion in the last decade, with researchers developing novel proteins with specialised functionalities for a range of uses, from drug discovery to industrial biotechnology. The emergenc
Externí odkaz:
https://doaj.org/article/197d7fb2352346288106a5ddabcd6c21
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Mycosporine-like amino acids (MAAs), including shinorine and porphyra-334, are gaining attention as safe natural sunscreens. The production of MAAs has been achieved in diverse microbial hosts, including Saccharomyces cerevisiae.
Externí odkaz:
https://doaj.org/article/21e1e1c58c274d2e8bf77a045629afe8
Autor:
Xianhao Xu, Xueqin Lv, Shixiu Cui, Yanfeng Liu, Hongzhi Xia, Jianghua Li, Guocheng Du, Zhaofeng Li, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu
Publikováno v:
Engineering, Vol 28, Iss , Pp 166-178 (2023)
Terpenoids are the largest family of natural products. They are made from the building block isoprene pyrophosphate (IPP), and their bioproduction using engineered cell factories has received a great deal of attention. To date, the insufficient metab
Externí odkaz:
https://doaj.org/article/ca938e727558457f9f2a7d988c5bb549
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-13 (2023)
Abstract In the post-genomic era, the demand for faster and more efficient protein production has increased, both in public laboratories and industry. In addition, with the expansion of protein sequences in databases, the range of possible enzymes of
Externí odkaz:
https://doaj.org/article/bd19bfc13ff7467f87e0ba5f8b3da5a8