Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Rodrigo L. O. R. Cunha"'
Autor:
Ivanildo A. Brito, Fernanda Thevenard, Thais A. Costa-Silva, Samuel S. Oliveira, Rodrigo L. O. R. Cunha, Emerson A. de Oliveira, Patricia Sartorelli, Rafael C. Guadagnin, Maiara M. Romanelli, Andre G. Tempone, João Henrique G. Lago
Publikováno v:
Molecules, Vol 27, Iss 3, p 893 (2022)
As part of our continuous studies involving the prospection of natural products from Brazilian flora aiming at the discovery of prototypes for the development of new antiparasitic drugs, the present study describes the isolation of two natural acetyl
Externí odkaz:
https://doaj.org/article/531831dd09e145699112039faad91c0d
Autor:
Cleverson R. Princival, Marcos V. L. R. Archilha, Alcindo A. Dos Santos, Maurício P. Franco, Ataualpa A. C. Braga, André F. Rodrigues-Oliveira, Thiago C. Correra, Rodrigo L. O. R. Cunha, João V. Comasseto
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4431-4439 (2017)
Externí odkaz:
https://doaj.org/article/42ee43c1dbf34a3d8e8d76e766af4687
Autor:
Natalia Girola, Pedro T. Resende-Lara, Carlos R. Figueiredo, Mariana H. Massaoka, Ricardo A. Azevedo, Rodrigo L. O. R. Cunha, Luciano Polonelli, Luiz R. Travassos
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Microtubules are important drug targets in tumor cells, owing to their role in supporting and determining the cell shape, organelle movement and cell division. The complementarity-determining regions (CDRs) of immunoglobulins have been reported to be
Externí odkaz:
https://doaj.org/article/127e3ac58e2645fbbcd2d8258bdd7894
Autor:
Carlos R. Figueiredo, Ricardo A. Azevedo, Sasha Mousdell, Pedro T. Resende-Lara, Lucy Ireland, Almudena Santos, Natalia Girola, Rodrigo L. O. R. Cunha, Michael C. Schmid, Luciano Polonelli, Luiz R. Travassos, Ainhoa Mielgo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatm
Externí odkaz:
https://doaj.org/article/2187804bb43e499384595d4ef3ffd93e
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 81, Iss 3, Pp 393-407 (2009)
Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organ
Externí odkaz:
https://doaj.org/article/b56f8ee3b7c043099456ca2b50689abc
Autor:
Juan Carlos Ramos Gonçalves, Helber Alves Negreiros, José Victor de Oliveira Santos, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Maria Luísa Lima Barreto do Nascimento, Paulo Michel Pinheiro Ferreira, Dalton Dittz, Débora Cavalcante Braz, Rodrigo L. O. R. Cunha, Felipe Cavalcanti Carneiro da Silva, Antonielly Campinho dos Reis, Adriana Maria Viana Nunes
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 21:1019-1026
Background: The search for novel metallic chemical compounds with toxicogenic effects has been of great importance for more efficient cancer treatment. Objective: The study evaluated the cytotoxic, genotoxic and mutagenic activity of organoteluran RF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826681e46d3df883322c697b5b1bd8c9
https://doi.org/10.2174/1871520620666200918110152
https://doi.org/10.2174/1871520620666200918110152
Autor:
Ivanildo A, Brito, Fernanda, Thevenard, Thais A, Costa-Silva, Samuel S, Oliveira, Rodrigo L O R, Cunha, Emerson A, de Oliveira, Patricia, Sartorelli, Rafael C, Guadagnin, Maiara M, Romanelli, Andre G, Tempone, João Henrique G, Lago
Publikováno v:
Molecules (Basel, Switzerland). 27(3)
As part of our continuous studies involving the prospection of natural products from Brazilian flora aiming at the discovery of prototypes for the development of new antiparasitic drugs, the present study describes the isolation of two natural acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::936e3e1cb7f1aed36998b4e37a08ca22
https://pubmed.ncbi.nlm.nih.gov/35164158
https://pubmed.ncbi.nlm.nih.gov/35164158
Publikováno v:
Zeitschrift für Kristallographie-New Crystal Structures, Vol 235, Iss 6, Pp 1535-1537 (2020)
C11H13Cl3O2Te, monoclinic, P21/c (no. 14), a = 11.0098(8) Å, b = 16.471(1) Å, c = 8.4975(7) Å, β = 99.421(7)°, V = 1520.17(19) Å3, Z = 4, R gt(F) = 0.0306, wR ref(F 2) = 0.0852, T = 293(2) K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05d6cdeb95784111c4b6901a10b6cc9
https://doi.org/10.1515/ncrs-2020-0380
https://doi.org/10.1515/ncrs-2020-0380
Autor:
Rodrigo L. O. R. Cunha, Gláucia Maria Machado-Santelli, Luiz R. Travassos, Adam A. Martens, Álvaro T. Omori, Felipe V. Pereira, Luiz Juliano, Thaysa Paschoalin
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2537-2545
Protease roles in cancer progression have been demonstrated and their inhibitors display antitumor effects. Cathepsins are lysosomal cysteine proteases that have increased expression in tumor cells, and tellurium compounds were described as potent cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99b89d29f17df5978043029ba81caba
https://doi.org/10.1016/j.bmc.2019.03.032
https://doi.org/10.1016/j.bmc.2019.03.032
Organotelluranes RT3 and RT4 are thiol reagents that induce mitochondrial transition pore (MTP) opening in a sensitive and insensitive manner to cyclosporin A. Although RT3 and RT4 promote glutathione depletion, paradoxically, they are also an effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9dfab5d88e9e4128a1296698b38cff0
https://doi.org/10.1101/2021.01.05.425411
https://doi.org/10.1101/2021.01.05.425411
