Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

Autor: Beatriz Martín-Antonio, Belén Blanco, África González-Murillo, Laura Hidalgo, Jordi Minguillón, Gema Pérez-Chacón, Next Generation CART MAD Consortium, Lucía Fernández, Halin Bareke, Andrés París-Muñoz, Adriana Mañas, Cristina Aguirre-Portolés, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Marta Ibáñez-Navarro, Laura Clares-Villa, Sara Naharro, Antonio Perez-Martinez, Marcos Aldea, María Gaibar, Javier Ruiz-Navarro, Manuel Izquierdo, Juan M. Zapata, África González Murillo, Elena García Sánchez, Jorge García Martínez, Alba Rubio San Simón, Blanca Herrero, Gonzalo García Aguilera, Beatriz Horcajo Morera, Manuel Ramírez Orellana, Belén Blanco-Durango, Anais Jiménez-Reinoso, Rodrigo Lázaro-Gorines, Ivana Zagorac, Antonio Tapia Galisteo, Ángel Ramirez-Fernández, Laura Díez-Alonso, Carmen Dominguez-Alonso, Ainhoa Erce-Llamazares, Oana Hangiu, Laura Rubio Pérez, Marina Gómez Rosel, Alejandro Segura Tudela, Javier Arroyo-Ródena, Luis Álvarez-Vallina, Miguel Ángel Rodríguez Milla, Patricia García Rodríguez, Beatriz Somovilla Crespo, Javier García-Castro, Esperanza Esquinas Tarifa, Juana Serrano-López, Pilar Llamas-Sillero, Beatriz Martin-Antonio

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Adoptive T cellular immunotherapies have emerged as relevant approaches for treating cancer patients who have relapsed or become refractory (R/R) to traditional cancer treatments. Chimeric antigen receptor (CAR) T-cell therapy has improved survival i

Externí odkaz: https://doaj.org/article/49d95b3c222f4b7389eb0625d73c49df

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

Autor: Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz, Luis Álvarez-Vallina

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTImmune checkpoint blockade (ICB) with antibodies has shown durable clinical responses in a wide range of cancer types, but the overall response rate is still limited. Other effective therapeutic modalities to increase the ICB response rates a

Externí odkaz: https://doaj.org/article/87732fe8a8464638935a3dfe1b8c3ab0

Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity

Autor: Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Ole A. Mandrup, Ainhoa Erce-Llamazares, Rodrigo Lázaro-Gorines, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Seandean L. Harwood, Carlos Alfonso, Belen Blanco, Laura Rubio-Pérez, Anaïs Jiménez-Reinoso, Laura Díez-Alonso, Francisco J. Blanco, Laura Sanz, Kenneth A. Howard, Luis Álvarez-Vallina

Publikováno v: iScience, Vol 25, Iss 9, Pp 104958- (2022)

Summary: Costimulation of tumor-infiltrating T lymphocytes by anti-4-1BB monoclonal antibodies (mAbs) has shown anti-tumor activity in human trials, but can be associated with significant off-tumor toxicities involving FcγR interactions. Here, we in

Externí odkaz: https://doaj.org/article/c486f101097e4624bed914bc95a337c3

Fungal Ribotoxins: A Review of Potential Biotechnological Applications

Autor: Miriam Olombrada, Rodrigo Lázaro-Gorines, Juan C. López-Rodríguez, Álvaro Martínez-del-Pozo, Mercedes Oñaderra, Moisés Maestro-López, Javier Lacadena, José G. Gavilanes, Lucía García-Ortega

Publikováno v: Toxins, Vol 9, Iss 2, p 71 (2017)

Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins, ribotoxins stand out as promising candidates

Externí odkaz: https://doaj.org/article/065b011d01894cdfb16390920455bd00

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Autor: Jaime Tome-Amat, Javier Lacadena, Javier Ruiz-de-la-Herrán, Rodrigo Lázaro-Gorines, José G. Gavilanes

Publikováno v: Toxins, ISSN 2072-6651, 2019-10, Vol. 11, No. 10
Toxins
Volume 11
Issue 10
Toxins, Vol 11, Iss 10, p 593 (2019)
Archivo Digital UPM
Universidad Politécnica de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
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E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid

Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immunotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30f7b0bbba2881d83084246202b9cbc
https://oa.upm.es/63636/