Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rodrigo I. Santos"'
Autor:
Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103363- (2024)
Summary: Previous work demonstrates that ebolaviruses can spread to neighboring cells through intercellular connections. Here, we present a protocol to quantify the intercellular spread of ebolaviruses via immunofluorescence. We describe steps for ce
Externí odkaz:
https://doaj.org/article/c25b044520a441e3997453ea720344af
Autor:
Rodrigo I. Santos, Philipp A. Ilinykh, Colette A. Pietzsch, Adam J. Ronk, Kai Huang, Natalia A. Kuzmina, Fuchun Zhou, James E. Crowe, Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113254- (2023)
Summary: Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV out
Externí odkaz:
https://doaj.org/article/8a1292785f724a3abef3fab20ae45612
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Powassan virus (POWV) is a neuroinvasive flavivirus transmitted to mammals by the bite of ixodid ticks. In this study, we sought to investigate the impact of tick salivary gland extract (SGE) on POWV neuroinvasion. BALB/c mice were footpad i
Externí odkaz:
https://doaj.org/article/af51e77a1f204ae9989dbb27e95d90ae
Autor:
Palaniappan Ramanathan, Bersabeh Tigabu, Rodrigo I. Santos, Philipp A. Ilinykh, Natalia Kuzmina, Olivia A. Vogel, Naveen Thakur, Hamza Ahmed, Chao Wu, Gaya K. Amarasinghe, Christopher F. Basler, Alexander Bukreyev
Publikováno v:
Viruses, Vol 15, Iss 5, p 1075 (2023)
Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less pathogenic, and Reston (RESTV) is not known to cause a disease in humans. The VP24 protein
Externí odkaz:
https://doaj.org/article/9daf9e18ecfc4868816c4867f5e79888
Autor:
Jingru Fang, Colette Pietzsch, Palaniappan Ramanathan, Rodrigo I. Santos, Philipp A. Ilinykh, Mariano A. Garcia-Blanco, Alexander Bukreyev, Shelton S. Bradrick
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Ebola virus (EBOV) genome and mRNAs contain long, structured regions that could hijack host RNA-binding proteins to facilitate infection. We performed RNA affinity chromatography coupled with mass spectrometry to identify host proteins that
Externí odkaz:
https://doaj.org/article/3e063c7ff21e4966a27fee9740480430
Autor:
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I. Santos, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Jr., Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1802-1815.e5 (2018)
Summary: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhance
Externí odkaz:
https://doaj.org/article/7731be7a37cd40b998e7c2e9e58cefde
Autor:
Saravanan Thangamani, Meghan E. Hermance, Rodrigo I. Santos, Mirko Slovak, Dar Heinze, Steven G. Widen, Maria Kazimirova
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Emerging and re-emerging diseases transmitted by blood feeding arthropods are significant global public health problems. Ticks transmit the greatest variety of pathogenic microorganisms of any blood feeding arthropod. Infectious agents transmitted by
Externí odkaz:
https://doaj.org/article/249944acead94ad98fe6f62ed568bf94
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific
Externí odkaz:
https://doaj.org/article/48b879ffa3974e9c88d3f79502e915e8
Autor:
Rodrigo I. Santos, Lézio S. Bueno-Júnior, Rafael N. Ruggiero, Mariana F. Almeida, Maria L. Silva, Flávia E. Paula, Vani M. A. Correa, Eurico Arruda
Publikováno v:
Viruses, Vol 6, Iss 10, Pp 3827-3836 (2014)
Oropouche virus (OROV) is an important cause of arboviral illness in Brazil and other Latin American countries, with most cases clinically manifested as acute febrile illness referred to as Oropouche fever, including myalgia, headache, arthralgia and
Externí odkaz:
https://doaj.org/article/2ddc49d4ec3749afa00120834d67527a
Publikováno v:
Viruses, Vol 8, Iss 8, p 220 (2016)
Powassan virus (POWV) belongs to the family Flaviviridae and is a member of the tick-borne encephalitis serogroup. Transmission of POWV from infected ticks to humans has been documented in the USA, Canada, and Russia, causing fatal encephalitis in 10
Externí odkaz:
https://doaj.org/article/89f8c48859904eb8b2f14bd7d6084f7b