Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Rodrigo Diéguez"'
Autor:
Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado, Hendrik Arf, Jian Song, Hongryeol Park, Kai Kruse, Lydia Sorokin, Ralf H Adams
Publikováno v:
eLife, Vol 11 (2022)
The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity at
Externí odkaz:
https://doaj.org/article/7930d253dc954807918d7e254c682b87
Autor:
Kathrin Koch, Maren Lindner, Ann-Katrin Fleck, Marie Liebmann, Melanie Eschborn, Lisa Zondler, Rodrigo Diéguez-Hurtado, Ralf H. Adams, Gerd Meyer zu Hörste, Alexander Zarbock, Tanja Kuhlmann, Heinz Wiendl, Luisa Klotz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13081 (2022)
Pericytes at the blood–brain barrier (BBB) are located between the tight endothelial cell layer of the blood vessels and astrocytic endfeet. They contribute to central nervous system (CNS) homeostasis by regulating BBB development and maintenance.
Externí odkaz:
https://doaj.org/article/9eb3bee76976410d8a417b45a429a70e
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Kathleen Hübner, Pauline Cabochette, Rodrigo Diéguez-Hurtado, Cora Wiesner, Yuki Wakayama, Kathrin S. Grassme, Marvin Hubert, Stefan Guenther, Heinz-Georg Belting, Markus Affolter, Ralf H. Adams, Benoit Vanhollebeke, Wiebke Herzog
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Wnt signaling is known to regulate the formation of the blood-brain barrier. Here Hübner et al. dissect the underlying mechanisms using high resolution live imaging in zebrafish, and find that Wnt regulates anastomosis of angiogenic sprouts in the b
Externí odkaz:
https://doaj.org/article/24e4c6a49599424898a125c7c9be3b6f
Autor:
Katsuhiro Kato, Rodrigo Diéguez-Hurtado, Do Young Park, Seon Pyo Hong, Sakiko Kato-Azuma, Susanne Adams, Martin Stehling, Britta Trappmann, Jeffrey L. Wrana, Gou Young Koh, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Pericytes surround endothelial tubules and help maintain the integrity of blood vessels. Here the authors show that pericytes regulate lung morphogenesis via paracrine signalling controlled by components of the Hippo pathway.
Externí odkaz:
https://doaj.org/article/a1d83014331540c8b3d754cb9ea4c153
Autor:
Hanna M. Eilken, Rodrigo Diéguez-Hurtado, Inga Schmidt, Masanori Nakayama, Hyun-Woo Jeong, Hendrik Arf, Susanne Adams, Napoleone Ferrara, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced e
Externí odkaz:
https://doaj.org/article/0c3a3cf9ba3b4c24826d8cf136e3439f
Autor:
Klotz, Kathrin Koch, Maren Lindner, Ann-Katrin Fleck, Marie Liebmann, Melanie Eschborn, Lisa Zondler, Rodrigo Diéguez-Hurtado, Ralf H. Adams, Gerd Meyer zu Hörste, Alexander Zarbock, Tanja Kuhlmann, Heinz Wiendl, Luisa
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13081
Pericytes at the blood–brain barrier (BBB) are located between the tight endothelial cell layer of the blood vessels and astrocytic endfeet. They contribute to central nervous system (CNS) homeostasis by regulating BBB development and maintenance.
Autor:
Alfred Nordheim, Regine Muehlfriedel, Ralf H. Adams, Christer Betsholtz, Michael Martin Orlich, Mathias W. Seeliger, Konstantin Gaengel, Hartwig Wolburg, Rodrigo Diéguez-Hurtado, Cansu Ebru Oender, Vithiyanjali Sothilingam, Pascal Woelffing
RationalePericytes (PCs) and vascular smooth muscle cells (vSMCs), collectively known as mural cells (MCs), are recruited through PDGFB-PDGFRB signaling. MCs are essential for vascular integrity, and their loss has been associated with numerous disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0738a305516ca5e61bd8f8274f03c9d9
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482404
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482404
Autor:
Tilman Borggrefe, Marek Bartkuhn, M. Gabriele Bixel, Hanna M. Eilken, Melina Nieminen-Kelhä, Ralf H. Adams, Hendrik Arf, Rodrigo Diéguez-Hurtado, Susanne Adams, Peter Vajkoczy, Benedetto Daniele Giaimo, Katsuhiro Kato, Tobias Zimmermann, Francesca Ferrante
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications
Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mes