Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rodrigo D. Requião"'
Autor:
Otávio Augusto Leitão Dos Santos, Rodolfo L. Carneiro, Rodrigo D. Requião, Marcelo Ribeiro-Alves, Tatiana Domitrovic, Fernando L. Palhano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract During protein synthesis, organisms detect translation defects that induce ribosome stalling and result in protein aggregation. The Ribosome-associated Quality Control (RQC) complex, comprising TCF25, LTN1, and NEMF, is responsible for ident
Externí odkaz:
https://doaj.org/article/5283165e22dd4ec78e3d19d2bd07fc72
Autor:
Otávio Augusto Leitão Dos Santos, Rodolfo L. Carneiro, Rodrigo D. Requião, Marcelo Ribeiro-Alves, Tatiana Domitrovic, Fernando L. Palhano
During protein synthesis, organisms constantly survey defective translation events that may lead to ribosome stalling with consequent ribosome collisions. Translation problems can result in misfolded protein products that sequester ribosomes into int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49be1a8ea2b5969ce8cf8249d797e368
https://doi.org/10.1101/2023.02.06.527332
https://doi.org/10.1101/2023.02.06.527332
Autor:
Rodrigo D Requião, Luiza Fernandes, Henrique José Araujo de Souza, Silvana Rossetto, Tatiana Domitrovic, Fernando L Palhano
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005549 (2017)
As proteins are synthesized, the nascent polypeptide must pass through a negatively charged exit tunnel. During this stage, positively charged stretches can interact with the ribosome walls and slow the translation. Therefore, charged polypeptides ma
Externí odkaz:
https://doaj.org/article/e36b374260774d9d93e997c346067ad7
Publikováno v:
Biochemical Journal. 477:2921-2934
Protein segments with a high concentration of positively charged amino acid residues are often used in reporter constructs designed to activate ribosomal mRNA/protein decay pathways, such as those involving nonstop mRNA decay (NSD), no-go mRNA decay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8689488d284c1eded4e11e8805677d87
https://doi.org/10.1042/bcj20200303
https://doi.org/10.1042/bcj20200303
Autor:
Rodrigo D. Requião, Marcelo Ribeiro-Alves, Tatiana Domitrovic, Fernando L. Palhano, Mariana H. Moreira, Rodolfo L. Carneiro, Silvana Rossetto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Capsid proteins often present a positively charged arginine-rich sequence at their terminal regions, which has a fundamental role in genome packaging and particle stability for some icosahedral viruses. These sequences show little to no conservation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6320f29df94424f861b851e5cec0fb52
http://link.springer.com/article/10.1038/s41598-020-62328-w
http://link.springer.com/article/10.1038/s41598-020-62328-w
Autor:
Mariana H. Moreira, Géssica C. Barros, Fernando L. Palhano, Rodrigo D. Requião, Silvana Rossetto, Tatiana Domitrovic
Publikováno v:
RNA Biol
Translation initiation is a critical step in the regulation of protein synthesis, and it is subjected to different control mechanisms, such as 5’ UTR secondary structure and initiation codon context, that can influence the rates at which initiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541251bd422ec7ee248aabc60665a592
https://doi.org/10.1080/15476286.2019.1661213
https://doi.org/10.1080/15476286.2019.1661213
Autor:
Tatiana Domitrovic, Silvana Rossetto, Rodolfo L. Carneiro, Fernando L. Palhano, Rodrigo D. Requião
Publikováno v:
Nucleic Acids Research
The codon stabilization coefficient (CSC) is derived from the correlation between each codon frequency in transcripts and mRNA half-life experimental data. In this work, we used this metric as a reference to compare previously published Saccharomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f036ac0c2b57a7fbda3258a1792a2a2
https://doi.org/10.1093/nar/gkz033
https://doi.org/10.1093/nar/gkz033
Autor:
Rodolfo L. Carneiro, Rodrigo D. Requião, Fernando L. Palhano, Silvana Rossetto, Marcelo Ribeiro-Alves, Mariana H. Moreira, Tatiana Domitrovic
Capsid proteins often present a positively charged arginine-rich region at the N and/or C-termini that for some icosahedral viruses has a fundamental role in genome packaging and particle stability. These sequences show little to no conservation at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8b65b9e73a80af0769a52c64a5e670
https://doi.org/10.1101/600981
https://doi.org/10.1101/600981
Autor:
Rodrigo D. Requião, Fernando L. Palhano, Silvana Rossetto, Claudio A. Masuda, Géssica C. Barros, Rodolfo L. Carneiro, Tatiana Domitrovic, Mariana H. Moreira
Publikováno v:
Journal of Biological Chemistry. 296:100586
Highly positively charged protein segments are known to result in poor translation efficiency. This effect is explained by ribosome stalling caused by electrostatic interactions between the nascent peptide and the negatively charged ribosome exit tun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903338e7806de6949dd0a5d0ef084736
https://doi.org/10.1016/j.jbc.2021.100586
https://doi.org/10.1016/j.jbc.2021.100586
Autor:
Silvana Rossetto, Rodrigo D. Requião, Fernando L. Palhano, Henrique José Araujo de Souza, Tatiana Domitrovic
Publikováno v:
RNA Biology. 13:561-568
It has been proposed that polybasic peptides cause slower movement of ribosomes through an electrostatic interaction with the highly negative ribosome exit tunnel. Ribosome profiling data—the sequencing of short ribosome-bound fragments of mRNA—i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779dc1efb4bef9ef21e9ba81a116cf02
https://doi.org/10.1080/15476286.2016.1172755
https://doi.org/10.1080/15476286.2016.1172755