Insomnia Polygenic Component on Attention Deficit-Hyperactivity Disorder: Exploring this Association Using Genomic Data from Brazilian Families

Autor: Marina Xavier Carpena, Brenda Barbon Fraga, Thais Martins-Silva, Angélica Salatino-Oliveira, Júlia Pasqualini Genro, Guilherme V. Polanczyk, Cristian Zeni, Marcelo Schmitz, Rodrigo Chazan, Mara Helena Hutz, Luis Augusto Rohde, Luciana Tovo-Rodrigues

Publikováno v: Sleep Science, Vol 17, Iss 02, Pp e194-e198 (2024)

Introduction Insomnia is highly prevalent among individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). However, the biological mechanisms shared between both conditions is still elusive. We aimed to investigate whether insomnia's genomic c

Externí odkaz: https://doaj.org/article/be3029a29edc4d4caf92f76d2830f93f

CLOCK polymorphisms in attention-deficit/hyperactivity disorder (ADHD) : further evidence linking sleep and circadian disturbances and ADHD

Autor: Rodrigo Chazan, Angélica Salatino-Oliveira, Marina Xavier Carpena, Mara H. Hutz, Guilherme V. Polanczyk, Marcelo Schmitz, Cristian Patrick Zeni, Luis Augusto Rohde, Luciana Tovo-Rodrigues, Julia P. Genro

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Genes
Volume 10
Issue 2
Genes, Vol 10, Iss 2, p 88 (2019)

Circadian and sleep disorders, short sleep duration, and evening chronotype are often present in attention-deficit/hyperactivity disorder (ADHD). CLOCK, considered the master gene in the circadian rhythm, has been explored by few studies. Understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c810204abbf307d85525744707e90377

LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study

Autor: Cristian Patrick Zeni, Mara H. Hutz, Estela M. Bruxel, Angélica Salatino-Oliveira, Luiz Rohde, Marcelo Schmitz, Guilherme V. Polanczyk, Rodrigo Chazan, Mauricio Arcos-Burgos, Glaucia Chiyoko Akutagava-Martins, Julia P. Genro, Luciana Tovo-Rodrigues

Publikováno v: Genes, Brain and Behavior. 14:419-427

Latrophilin 3 (LPHN3) is a brain-specific member of the G-protein coupled receptor family associated to both attention-deficit/hyperactivity disorder (ADHD) genetic susceptibility and methylphenidate (MPH) pharmacogenetics. Interactions of LPHN3 vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb41ee9c93db3f67567bd19a3abf5746
https://doi.org/10.1111/gbb.12224

Association study ofGIT1gene with attention-deficit hyperactivity disorder in Brazilian children and adolescents

Autor: Guilherme V. Polanczyk, Angélica Salatino-Oliveira, Tatiana Roman, Rodrigo Chazan, Cristian Patrick Zeni, Mara H. Hutz, Luis Augusto Rohde, Marcelo Schmitz, Julia P. Genro

Publikováno v: Genes, Brain and Behavior. 11:864-868

Attention-deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with a worldwide prevalence of 5.3%. Recently, a Korean group assessed the G-protein-coupled receptor kinase-interacting protein 1 (GIT1) gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c54236e7f06cab9a873a22b05819241
https://doi.org/10.1111/j.1601-183x.2012.00835.x

Catechol-O-Methyltransferase Valine158Methionine Polymorphism Moderates Methylphenidate Effects on Oppositional Symptoms in Boys with Attention-Deficit/Hyperactivity Disorder

Autor: Mara H. Hutz, Ana P. Guimarães, Guilherme V. Polanczyk, Cristian Patrick Zeni, Angélica Salatino-Oliveira, Julia P. Genro, Rodrigo Chazan, Luis Augusto Rohde, Sidia M. Callegari-Jacques

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background The catechol- O -methyltransferase enzyme plays a key role in the function of prefrontal cortex, accounting for most of the degradation of dopamine. Previous studies have documented the improvement of oppositional symptoms in attention-def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2a45ded06b312c2bd9aff911ad7c3a
https://doi.org/10.1016/j.biopsych.2011.03.025