Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Rodrigo B Leal"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152905 (2016)
Carboxypeptidase A6 (CPA6) is an extracellular matrix metallocarboxypeptidase that modulates peptide and protein function by removal of hydrophobic C-terminal amino acids. Mutations in the human CPA6 gene that reduce enzymatic activity in the extrace
Externí odkaz:
https://doaj.org/article/87da2a20d5134553a816948a0270a596
Autor:
Fabiano M Cordova, Aderbal S Aguiar, Tanara V Peres, Mark W Lopes, Filipe M Gonçalves, Aline P Remor, Samantha C Lopes, Célso Pilati, Alexandra S Latini, Rui D S Prediger, Keith M Erikson, Michael Aschner, Rodrigo B Leal
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33057 (2012)
Manganese (Mn) is an essential metal for development and metabolism. However, exposures to high Mn levels may be toxic, especially to the central nervous system (CNS). Neurotoxicity is commonly due to occupational or environmental exposures leading t
Externí odkaz:
https://doaj.org/article/f16e7b7814864728b045cbe9c9aab524
Autor:
Ruth L. Quispe, Michael L. Jaramillo, Ingrid A. V. Wolin, Rômulo F. S. Canto, Flavio A. R. Barbosa, Antônio L. Braga, João B. T. Rocha, Michael Aschner, Rodrigo B. Leal, Andreza F. de Bem, Marcelo Farina
Publikováno v:
Neurotoxicity Research. 40:127-139
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling
Autor:
Yasmim de Oliveira Dalsenter, Morgana Moretti, Mauren K. Tavares, Priscila B. Rosa, Ana Lúcia S. Rodrigues, Daiane B. Fraga, Isabella A. Heinrich, Fernanda Neutzling Kaufmann, Luis E.B. Bettio, Vivian B. Neis, Andiara E. Freitas, Rodrigo B. Leal, Nicolle Platt, Isabel Werle, Axel Fogaça Rosado
Publikováno v:
Purinergic Signal
Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but the mechanisms underlying its effect are not well established. We investigated if the antidepressant-like effect induced by guanosine in the tail suspension t
Autor:
Roger Walz, Ana Lúcia S. Rodrigues, Rodrigo B. Leal, Ana Paula M. Nascimento, Isabella A. Heinrich, Andiara E. Freitas, Ingrid A.V. Wolin
Publikováno v:
Metabolic Brain Disease. 36:711-722
Fluoxetine is the foremost prescribed antidepressant. Drugs acting on monoaminergic system may also regulate glutamatergic system. Indeed, the investigation of proteins associated with this system, such as Narp (neuronal activity-dependent pentraxin)
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone
Autor:
Jefferson Luiz Brum Marques, Jeremy M. Henley, Katia Lin, Mark William Lopes, Roger Walz, Peter Wolf, Alexandre Ademar Hoeller, Zuner A. Bortolotto, André D’Ávila, Cristiane Ribeiro de Carvalho, Hiago Murilo Melo, Guilherme L. Fialho, Rodrigo B. Leal, Marcelo Neves Linhares
Publikováno v:
Molecular Neurobiology. 58:1859-1870
The central autonomic network, which is connected to the limbic system structures including the amygdala (AMY) and anterior hippocampus (aHIP), regulates the sympathetic and parasympathetic modulation of visceromotor, neuroendocrine, pain, and behavi
Autor:
Gudrian Ricardo Lopes de Almeida, Jozimar Carlos Szczepanik, Alcir Luiz Dafre, Gabriela Cristina de Paula, Isabella A. Heinrich, Ariana Ern Schmitz, Mauricio P. Cunha, Barbara dos Santos, Rodrigo B. Leal, Ingrid Selhorst, Andreza Fabro de Bem
Publikováno v:
Molecular Neurobiology. 58:735-749
Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer’s disease, and inflammation. Cell culture studies reported that MGO could impair the glyoxalase, thioredoxin, and
Autor:
Benildo Sousa Cavada, Larissa da Silva Chicas, Ivanice Bezerra Silva, Rodrigo B. Leal, Daniel Lucena Domingues, Maria Lucia Lira de Andrade, Ana Paula M. Nascimento, Gabriela Fernandes Oliveira Marques, Pedro Henrique de Souza Ferreira Bringel, Mayara Torquato Lima Silva, Claudia Figueiredo Lossio, Kyria S. Nascimento, Ana Maria Sampaio Assreuy, Maria Gleiciane de Queiroz Martins, Ingrid A.V. Wolin
Publikováno v:
International Journal of Biological Macromolecules. 156:1-9
Lectins from Diocleinae subtribe species (family Leguminosae) are of special interest since they present a wide spectrum of biological activities, despite their high structural similarity. During their synthesis in plant cells, these proteins undergo
Autor:
Liliana del Valle Sosa, Ana Clara Venier, Silvina Gutiérrez, Ezequiel Grondona, Alicia Inés Torres, Natacha Zlocowski, Rodrigo B. Leal, Ana Lucía De Paul, Alexandra Latini, Bethania Mongi-Bragato
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The molecular mechanisms underlying the capability of pituitary tumours to avoid unregulated cell proliferation are still not well understood. However, the NF-κB transcription factor, which is able to modulate not only cellular senescence but also t
Autor:
Priscila B. Rosa, Luis E.B. Bettio, Isabel Werle, Morgana Moretti, Rodrigo B. Leal, Vivian B. Neis, Ana Lúcia S. Rodrigues
Publikováno v:
Purinergic Signal
Although guanosine is an endogenous nucleoside that displays antidepressant-like properties in several animal models, the mechanism underlying its antidepressant-like effects is not well characterized. The present study aimed at investigating the inv