Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rodrigo Aguayo-Ortíz"'
Autor:
José Luis Madrigal-Angulo, Carlos Ménez-Guerrero, Samuel Estrada-Soto, Juan José Ramírez-Espinosa, Julio César Almanza-Pérez, Ismael León-Rivera, Emanuel Hernández-Núñez, Yoshajandith Aguirre-Vidal, Carlos D. Flores-León, Rodrigo Aguayo-Ortíz, Gabriel Navarrete-Vazquez
Publikováno v:
Bioorganicmedicinal chemistry letters. 70
In current work, we prepared a series of nine 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones using a two-step pathway. Compounds 1-9 were tested in vitro using a set of three proteins recognized as important targets in diabetes and related dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552d9dc0b4ef9f3e79c4b24c3b4036b3
https://pubmed.ncbi.nlm.nih.gov/35598791
https://pubmed.ncbi.nlm.nih.gov/35598791
Autor:
Miriam Díaz-Rojas, Martin González-Andrade, Rodrigo Aguayo-Ortiz, Rogelio Rodríguez-Sotres, Araceli Pérez-Vásquez, Abraham Madariaga-Mazón, Rachel Mata
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
This work aimed to discover protein tyrosine phosphatase 1B (PTP1B) inhibitors from a small molecule library of natural products (NPs) derived from selected Mexican medicinal plants and fungi to find new hits for developing antidiabetic drugs. The pr
Externí odkaz:
https://doaj.org/article/05e6978ed0304e5581f30093b1d3dda1
Autor:
Carlos Martínez-Conde, Blanca Colín-Lozano, Abraham Gutiérrez-Hernández, Emanuel Hernández-Núñez, Lilián Yépez-Mulia, Luis Fernando Colorado-Pablo, Rodrigo Aguayo-Ortiz, Jaime Escalante, Julio C. Rivera-Leyva, Jessica Nayelli Sánchez-Carranza, Elizabeth Barbosa-Cabrera, Gabriel Navarrete-Vazquez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14949 (2023)
Parasitic diseases, including giardiasis caused by Giardia lamblia (G. lamblia), present a considerable global health burden. The limited effectiveness and adverse effects of current treatment options underscore the necessity for novel therapeutic co
Externí odkaz:
https://doaj.org/article/96f4cfda6d4e43ccbae13f1cc4ef8fbe
Autor:
Andy Y. Liu, Rodrigo Aguayo-Ortiz, Guadalupe Guerrero-Serna, Nulang Wang, Muriel G. Blin, Daniel R. Goldstein, L. Michel Espinoza-Fonseca
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 380-384 (2022)
Phospholamban (PLN) and Sarcolipin (SLN) are homologous membrane proteins that belong to the family of proteins that regulate the activity of the cardiac calcium pump (sarcoplasmic reticulum Ca2+-ATPase, SERCA). PLN and SLN share highly conserved leu
Externí odkaz:
https://doaj.org/article/9e4f8ec9e0414fe08348b6802eddd02a
Autor:
Carlos D. Flores-León, Luis Fernando Colorado-Pablo, Miguel Á. Santos-Contreras, Rodrigo Aguayo-Ortiz
Publikováno v:
Frontiers in Drug Discovery, Vol 2 (2023)
Human epigenetic enzyme disruptor of telomeric silencing 1-like (DOT1L) is a key drug target for treating acute myeloid leukemia. Several nucleoside and non-nucleoside DOT1L inhibitors have been developed to inhibit its histone methyltransferase acti
Externí odkaz:
https://doaj.org/article/cc6a778d6a8e4ca3bfeee924d2616664
Autor:
Rodrigo Aguayo-Ortiz, Jeffery Creech, Eric N. Jiménez-Vázquez, Guadalupe Guerrero-Serna, Nulang Wang, Andre Monteiro da Rocha, Todd J. Herron, L. Michel Espinoza-Fonseca
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting “undruggable” regions of membrane proteins to
Externí odkaz:
https://doaj.org/article/39ac1d8d1b97427ba94cce0ca3901e15
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 705-713 (2020)
Sarcoplasmic reticulum Ca2+ pump (SERCA) is a critical component of the Ca2+ transport machinery in myocytes. There is clear evidence for regulation of SERCA activity by PLB, whose activity is modulated by phosphorylation of its N-terminal domain (re
Externí odkaz:
https://doaj.org/article/72dd00a178e94cbab4530c66acc069cc
Autor:
M'Lynn E Fisher, Elisa Bovo, Rodrigo Aguayo-Ortiz, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young
Publikováno v:
eLife, Vol 10 (2021)
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor phospholamban. A new regulator, dwarf open reading frame (DWORF), has been re
Externí odkaz:
https://doaj.org/article/87991ab8aa184f75a15e117bb6842178
Autor:
Maritere Uriostegui-Arcos, Rodrigo Aguayo-Ortiz, María del Pilar Valencia-Morales, Erika Melchy-Pérez, Yvonne Rosenstein, Laura Dominguez, Mario Zurita
Publikováno v:
Open Biology, Vol 10, Iss 6 (2020)
Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between
Externí odkaz:
https://doaj.org/article/ee28c7419a534ba9b9149e592f226f14
Autor:
Víctor Martínez-Rosas, Beatriz Hernández-Ochoa, Gabriel Navarrete-Vázquez, Carlos Martínez-Conde, Fernando Gómez-Chávez, Laura Morales-Luna, Abigail González-Valdez, Roberto Arreguin-Espinosa, Sergio Enríquez-Flores, Verónica Pérez de la Cruz, Rodrigo Aguayo-Ortiz, Carlos Wong-Baeza, Isabel Baeza-Ramírez, Saúl Gómez-Manzo
Publikováno v:
Molecules, Vol 27, Iss 4, p 1174 (2022)
Trichomoniasis is a sexually transmitted disease with a high incidence worldwide, affecting 270 million people. Despite the existence of a catalog of available drugs to combat this infection, their extensive use promotes the appearance of resistant T
Externí odkaz:
https://doaj.org/article/d7eb153ffb6943c69fc122bb7ddd4799