Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Rodrigo A. Grandy"'
Autor:
Giovanni Canu, Emmanouil Athanasiadis, Rodrigo A. Grandy, Jose Garcia-Bernardo, Paulina M. Strzelecka, Ludovic Vallier, Daniel Ortmann, Ana Cvejic
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endothelial cells which undergo endothelial-to-haematopoietic transition (EH
Externí odkaz:
https://doaj.org/article/f031a1a8c22e4eac9643b185f66b7a70
Autor:
Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 165-179 (2019)
Summary: Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these interplays at the molecular level remains challenging due to the lack of efficient methods allowing cell c
Externí odkaz:
https://doaj.org/article/1845b195505f44a78af9a9414bb07768
Autor:
Julian E. Sale, Alastair Crisp, Cara B. Eldridge, Finian J. Allen, Rodrigo A. Grandy, Ludovic Vallier
Publikováno v:
Stem Cell Reports
Summary The ability of human induced pluripotent stem cells (hiPSCs) to differentiate in vitro to each of the three germ layer lineages has made them an important model of early human development and a tool for tissue engineering. However, the factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d9ba43813a50567ccb044d62b4dc41
https://doi.org/10.1016/j.stemcr.2020.08.003
https://doi.org/10.1016/j.stemcr.2020.08.003
Autor:
Ludovic Vallier, Rodrigo A. Grandy, Daniel Ortmann, Ana Cvejic, Emmanouil Athanasiadis, Giovanni Canu, Paulina M. Strzelecka, Jose Garcia-Bernardo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-28 (2020)
Genome Biology
Genome Biology
Funder: INTENS EU fp8 consortium
Funder: ERC advanced grant New-Chol
Background: Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endot
Funder: ERC advanced grant New-Chol
Background: Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1048c73f14726bb5794189a6d600226a
http://link.springer.com/article/10.1186/s13059-020-02058-4
http://link.springer.com/article/10.1186/s13059-020-02058-4
Autor:
Rodrigo A. Grandy, Loukia Yiangou, Daniel Ortmann, Ludovic Vallier, Anna Osnato, Sanjay Sinha
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The mesoderm is one of the three germ layers produced during gastrulation from which muscle, bones, kidneys, and the cardiovascular system originate. Understanding the mechanisms that control mesoderm specification could inform many applications, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a703c7bd59c722ba9e2b476a91a67
https://doi.org/10.1074/jbc.ra119.008251
https://doi.org/10.1074/jbc.ra119.008251
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease
Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to advancing this enterprise, their limitation in modeling all the aspects of complex human dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da29db177b1069dae6376ba908a41015
https://doi.org/10.1146/annurev-pathol-020117-043634
https://doi.org/10.1146/annurev-pathol-020117-043634
Autor:
Rodrigo A. Grandy, Anna Osnato, Pedro Madrigal, Siim Pauklin, Daniel Ortmann, Ludovic Vallier, Kim Jee Goh, Stephanie Brown
Most mammalian stem cells undergo cellular division during their differentiation to produce daughter cells with a new cellular identity. However, the cascade of epigenetic events and molecular mechanisms occurring between successive cell divisions up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de77488ba024a8cd5b67b23d952b3902
https://doi.org/10.1101/2020.06.26.173211
https://doi.org/10.1101/2020.06.26.173211
Autor:
Jennifer VanOudenhove, Sayyed K. Zaidi, Jane B. Lian, Prachi N. Ghule, Janet L. Stein, Rodrigo A. Grandy, Gary S. Stein
Publikováno v:
Journal of Cellular Physiology. 232:1254-1257
The cell cycle in pluripotent human embryonic stem cells is governed by unique mechanisms that support unrestricted proliferation and competency for endodermal, mesodermal, and ectodermal differentiation. The abbreviated G1 period with retention of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201653e6d2bf4bf2c22c501a1f8d552c
https://doi.org/10.1002/jcp.25567
https://doi.org/10.1002/jcp.25567
Mesoderm is one of the three germ layers produced during gastrulation from which muscle, bones, kidneys and the cardiovascular system originate. Understanding the mechanisms controlling mesoderm specification could be essential for a diversity of app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbb3c52eb5b4201e433d27ea0ef441c
Autor:
Rodrigo A. Grandy, Gary S. Stein, Janet L. Stein, Joseph R. Boyd, Sayyed K. Zaidi, Ricardo F. Medina, Jane B. Lian
Publikováno v:
Journal of Cellular Physiology. 231:2007-2013
Embryonic stem cells (ESCs) exhibit unrestricted and indefinite, but stringently controlled, proliferation, and can differentiate into any lineage in the body. In the current study, we test the hypothesis that expression of ribosomal RNA (rRNA) and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026fd305336213f44fd9593b33181af5
https://doi.org/10.1002/jcp.25309
https://doi.org/10.1002/jcp.25309