Výsledky vyhledávání - "Rodrigo, Lombraña"

Akademický článek

Chromatin conformation regulates the coordination between DNA replication and transcription

Autor: Ricardo Almeida, José Miguel Fernández-Justel, Cristina Santa-María, Jean-Charles Cadoret, Laura Cano-Aroca, Rodrigo Lombraña, Gonzalo Herranz, Alessandra Agresti, María Gómez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA r

Externí odkaz: https://doaj.org/article/399d7ceb0c43497db1da7ece90fc06c8

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Akademický článek

Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

Autor: Rodrigo Lombraña, Alba Álvarez, José Miguel Fernández-Justel, Ricardo Almeida, César Poza-Carrión, Fábia Gomes, Arturo Calzada, José María Requena, María Gómez

Publikováno v: Cell Reports, Vol 16, Iss 6, Pp 1774-1786 (2016)

Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across diffe

Externí odkaz: https://doaj.org/article/735d1240a7a04d1c9d6fae8a4de76c0d

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Akademický článek

Strand‐specific, high‐resolution mapping of modified RNA polymerase II

Autor: Laura Milligan, Vân A Huynh‐Thu, Clémentine Delan‐Forino, Alex Tuck, Elisabeth Petfalski, Rodrigo Lombraña, Guido Sanguinetti, Grzegorz Kudla, David Tollervey

Publikováno v: Molecular Systems Biology, Vol 12, Iss 6, Pp 1-15 (2016)

Abstract Reversible modification of the RNAPII C‐terminal domain links transcription with RNA processing and surveillance activities. To better understand this, we mapped the location of RNAPII carrying the five types of CTD phosphorylation on the

Externí odkaz: https://doaj.org/article/0409b0dae53f4906ad18cf6fa2f647a8

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Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major

Autor: José Carlos Solana, Jose M. Requena, Alberto Rastrojo, Laura Corvo, Rodrigo Lombraña, Begoña Aguado

Publikováno v: Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)

Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe234ac0fe06248808812c9606db80be
https://doi.org/10.1038/s41598-019-43354-9

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Chromatin conformation regulates the coordination between DNA replication and transcription

Autor: Alessandra Agresti, Laura Cano-Aroca, Ricardo Almeida, Rodrigo Lombraña, Gonzalo Herranz, María Gómez, Cristina Santa-María, Jean-Charles Cadoret, José Miguel Fernández-Justel

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Chromatin is the template for the basic processes of replication and transcription, making the maintenance of chromosomal integrity critical for cell viability. To elucidate how dividing cells respond to alterations in chromatin structure, here we an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a69b09d88a849a7c7b6e7d8346e52c2
https://pubmed.ncbi.nlm.nih.gov/29686321

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Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

Autor: Arturo Calzada, Fábia Gomes, Alba Garcimartín Álvarez, Jose M. Requena, César Poza-Carrión, José Miguel Fernández-Justel, María Gómez, Ricardo Almeida, Rodrigo Lombraña

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports, Vol 16, Iss 6, Pp 1774-1786 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1237f222cea3ac1f42ae4dce4937366f
http://hdl.handle.net/10261/152216

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Strand-specific, high-resolution mapping of modified RNA polymerase II

Autor: Laura, Milligan, Vân A, Huynh-Thu, Clémentine, Delan-Forino, Alex, Tuck, Elisabeth, Petfalski, Rodrigo, Lombraña, Guido, Sanguinetti, Grzegorz, Kudla, David, Tollervey

Publikováno v: Molecular Systems Biology

Reversible modification of the RNAPII C‐terminal domain links transcription with RNA processing and surveillance activities. To better understand this, we mapped the location of RNAPII carrying the five types of CTD phosphorylation on the RNA trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::decec78c5c91370e7a6e111041a1347e
http://hdl.handle.net/20.500.11767/117343

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R-loops and initiation of DNA replication in human cells: a missing link?

Autor: Ricardo Almeida, Alba Garcimartín Álvarez, Rodrigo Lombraña, María Gómez

Publikováno v: Frontiers in Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Genetics, Vol 6 (2015)

The unanticipated widespread occurrence of stable hybrid DNA/RNA structures (R-loops) in human cells and the increasing evidence of their involvement in several human malignancies have invigorated the research on R-loop biology in recent years. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8450afe5e14c50940390b1d13eed99
http://hdl.handle.net/10261/152845

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High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins

Autor: Gonzalo Herranz, María Gómez, Sofia Madeira, Ricardo Almeida, Ugo Bastolla, Isabel Revuelta, Néstor Saiz, Rodrigo Lombraña

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

DNA replication origins are poorly characterized genomic regions that are essential to recruit and position the initiation complex to start DNA synthesis. Despite the lack of specific replicator sequences, initiation of replication does not occur at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934cf17ca6341066dcb63d51405e1752
https://pubmed.ncbi.nlm.nih.gov/23995398

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