Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.

Autor: Lakeman IMM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Rodríguez-Girondo MDM; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands., Lee A; Public Health and Primary Care, University of Cambridge Centre for Cancer Genetic Epidemiology, Cambridge, UK., Celosse N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Braspenning ME; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., van Engelen K; Department of Human Genetics, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands., van de Beek I; Department of Human Genetics, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands., van der Hout AH; Department of Clinical Genetics, University Medical Centre Groningen, Groningen, The Netherlands., Gómez García EB; Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands., Mensenkamp AR; Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands., Ausems MGEM; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands., Hooning MJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Adank MA; Family Cancer Clinic, Antoni van Leeuwenhoek Netherlands Cancer Institute, Amsterdam, The Netherlands., Hollestelle A; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Schmidt MK; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Division of Psychosocial Research and Epidemiology, Antoni van Leeuwenhoek Netherlands Cancer Institute, Amsterdam, The Netherlands., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Devilee P; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands p.devilee@lumc.nl.; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of medical genetics [J Med Genet] 2023 Apr; Vol. 60 (4), pp. 327-336. Date of Electronic Publication: 2022 Sep 22.