Výsledky vyhledávání - "Rodríguez-Gimeno A"

Comprehensive

Autor: Natalia, Sacilotto, Paola, Dessanti, Michele M P, Lufino, Alberto, Ortega, Alejandra, Rodríguez-Gimeno, Jordi, Salas, Tamara, Maes, Carlos, Buesa, Cristina, Mascaró, Robert, Soliva

Publikováno v: ACS pharmacologytranslational science. 4(6)

Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdb475af769419458a84503ed2b670c4
https://pubmed.ncbi.nlm.nih.gov/34927013

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Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

Autor: Elvira Sondo, Alejandra Rodríguez-Gimeno, Federico Sorana, Ambra Gianotti, Luis J. V. Galietta, Loretta Ferrera, Fabio Bertozzi, Emanuela Caci, Nicoletta Pedemonte, Paolo Scudieri, Francesco Berti, Emanuela Pesce, Tiziano Bandiera, Paolo Di Fruscia, Valeria Tomati

Publikováno v: Science Advances

We identified a small molecule that, at picomolar concentrations, rescues mutant CFTR chloride channel from protein degradation.
F508del, the most frequent mutation causing cystic fibrosis (CF), results in mistrafficking and premature degradatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044383cc22cf034f23466b9e5b900469
https://pubmed.ncbi.nlm.nih.gov/32128418

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Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology.

Autor: Sacilotto, Natalia, Dessanti, Paola, Lufino, Michele M. P., Ortega, Alberto, Rodríguez-Gimeno, Alejandra, Salas, Jordi, Maes, Tamara, Buesa, Carlos, Mascaró, Cristina, Soliva, Robert

Publikováno v: ACS Pharmacology & Translational Science; 12/10/2021, Vol. 4 Issue 6, p1818-1834, 17p

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Polysulfonylamine, CXCII [1]. Polynäre Verbindungen aus Di(4-fluorbenzolsulfonyl) amin (FAH), 1,1,3-Trimethylharnstoff (TrMU) und Dimethylamin (Me2NH): Bildung und Strukturen des Cokristalls FAH·TrMU (Z′ = 1), des Salzes Me2NH2 +·FA– (Z′ = 6) und des Salz-Cokristalls FAH·TrMU·Me2NH2 +·FA– (Z′ = 1). Bemerkungen zur Oxophobie von C–F-Gruppen in Kristallstrukturen / Polysulfonylamines, CXCII. Polynary Compounds Based upon Di(4-fluorobenzenesulfonyl)amine (FAH), 1,1,3-Trimethylurea (TrMU) and Dimethylamine (Me2NH): Formation and Structures of the Cocrystal FAH·TrMU (Z′ = 1), the Salt Me2 NH2 +·FA− (Z′ = 6) and the Salt Cocrystal FAH·TrMU·Me2NH2 +·FA− (Z′ = 1). Comments on the Oxophobia of C–F Groups in Crystal Structures

Autor: Christoph Wölper, Alejandra Rodríguez-Gimeno, Katherine Chulvi Iborra, Ina Dix, Matthias Freytag, Peter G. Jones, Armand Blaschette

Publikováno v: Zeitschrift für Naturforschung B. 66:1161-1174

Cocrystallization of di(4-fluorobenzenesulfonyl)amine, (4-F-C6H4SO2)2NH (= FAH), with 1,3,3- trimethylurea (TrMU) from dichloromethane/petroleum ether afforded the molecular cocrystal FAH・TrMU (1, monoclinic, P21/n, Z′ = 1) and the salt cocrystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ec7933cedfe07d77fbd9a2c92555119
https://doi.org/10.1515/znb-2011-1112

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Polysulfonylamine, CLXXXIX [1]. Weitere Beispiele für die O-Protonierung von Harnstoffen mit Di(organosulfonyl)aminen: Bildung und Kristallstrukturen von 1,1-Dimethyluroniumdi( 4-fluorbenzolsulfonyl)amid und Di(1-methylharnstoff)- hydrogen(I)-di(4-fluorbenzolsulfonyl)amid/ Polysulfonylamines, CLXXXIX. Additional Examples of the O-Protonation of Ureas by Di(organosulfonyl)amines: Formation and Crystal Structures of 1,1-Dimethyluronium Di(4-fluorobenzenesulfonyl)amide and Di(1-methylurea)hydrogen(I)Di(4-fluorobenzenesulfonyl) amide

Autor: Wölper, C., Alejandra Rodríguez-Gimeno, Iborra, K. C., Jones, P. G., Blaschette, A.

Publikováno v: Scopus-Elsevier

Co-crystallization of N-methyl-substituted ureas with di(organosulfonyl)amines, (RSO2)2NH, leads unpredictably to either molecular co-crystals or, via proton transfer, to uronium salts. As a sequel to former reports, this communication describes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c6f067a1cf38a733f91be3382f4ec7
https://doi.org/10.1515/znb-2010-1112

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Polysulfonylamine, CLXXXVIII [1]. Kristallstrukturen von drei Dimethylammonium-di(4-halogenbenzolsulfonyl)amiden (Halogen = Cl, Br, I) und von Dimethylammonium-di(4-methylbenzolsulfonyl)amid: Eine isotype Reihe mit strukturbestimmenden starken Wasserstoffbrücken und beiläufigen Halogenbrücken/ Polysulfonylamines, CLXXXVIII. Crystal Structures of Three Dimethylammonium Di(4-halobenzenesulfonyl)amides (Halogen = Cl, Br, I) and of Dimethylammonium Di(4-methylbenzenesulfonyl)amide: An Isotypical Series Featuring Strong Structure-determining Hydrogen Bonds and Incidental Halogen Bonds

Autor: Matthias Freytag, Alejandra Rodríguez-Gimeno, Armand Blaschette, Christoph Wölper, Peter G. Jones

Publikováno v: Zeitschrift für Naturforschung B. 65:1258-1266

The four title compounds, Me2NH2 +·(4-Cl/Br/I/Me-C6H4-SO2)2N-, were obtained by metathesis of dimethylammonium chloride with the corresponding silver di(arenesulfonyl)amides. The products crystallize isotypically in the monoclinic space group Cc (Z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f2313bc5a3a1499d562eea91b297b08
https://doi.org/10.1515/znb-2010-1013

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