New insights into the genetic etiology of Alzheimer's disease and related dementias

Autor: Bellenguez, Céline, Küçükali, Fahri, Jansen, Iris E., Kleineidam, Luca, Moreno-Grau, Sonia, Amin, Najaf, Naj, Adam C., Campos-Martin, Rafael, Grenier-Boley, Benjamin, Andrade, Victor, Holmans, Peter A., Boland, Anne, Damotte, Vincent, van der Lee, Sven J., Costa, Marcos R., Kuulasmaa, Teemu, Yang, Qiong, de Rojas, Itziar, Bis, Joshua C., Yaqub, Amber, Prokic, Ivana, Chapuis, Julien, Ahmad, Shahzad, Giedraitis, Vilmantas, Aarsland, Dag, Garcia-Gonzalez, Pablo, Abdelnour, Carla, Alarcón-Martín, Emilio, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Álvarez, Victoria, Armstrong, Nicola J., Tsolaki, Anthoula, Antúnez, Carmen, Appollonio, Ildebrando, Arcaro, Marina, Archetti, Silvana, Pastor, Alfonso Arias, Arosio, Beatrice, Athanasiu, Lavinia, Bailly, Henri, Banaj, Nerisa, Baquero, Miquel, Barral, Sandra, Beiser, Alexa, Pastor, Ana Belén, Below, Jennifer E., Benchek, Penelope, Benussi, Luisa, Berr, Claudine, Besse, Céline, Bessi, Valentina, Binetti, Giuliano, Bizarro, Alessandra, Blesa, Rafael, Boada, Mercè, Boerwinkle, Eric, Borroni, Barbara, Boschi, Silvia, Bossù, Paola, Bråthen, Geir, Bressler, Jan, Bresner, Catherine, Brodaty, Henry, Brookes, Keeley J., Brusco, Luis Ignacio, Buiza-Rueda, Dolores, Bûrger, Katharina, Burholt, Vanessa, Bush, William S., Calero, Miguel, Cantwell, Laura B., Chene, Geneviève, Chung, Jaeyoon, Cuccaro, Michael L., Carracedo, Ángel, Cecchetti, Roberta, Cervera-Carles, Laura, Charbonnier, Camille, Chen, Hung-Hsin, Chillotti, Caterina, Ciccone, Simona, Claassen, Jurgen A H R, Clark, Christopher, Conti, Elisa, Corma-Gómez, Anaïs, Costantini, Emanuele, Custodero, Carlo, Daian, Delphine, Dalmasso, Maria Carolina, Daniele, Antonio, Dardiotis, Efthimios, Dartigues, Jean-François, de Deyn, Peter Paul, de Paiva Lopes, Katia, de Witte, Lot D., Debette, Stéphanie, Deckert, Jürgen, Del Ser, Teodoro, Denning, Nicola, DeStefano, Anita, Dichgans, Martin, Diehl-Schmid, Janine, Diez-Fairen, Mónica, Rossi, Paolo Dionigi, Djurovic, Srdjan, Duron, Emmanuelle, Düzel, Emrah, Dufouil, Carole, Eiriksdottir, Gudny, Engelborghs, Sebastiaan, Escott-Price, Valentina, Espinosa, Ana, Ewers, Michael, Faber, Kelley M., Fabrizio, Tagliavini, Nielsen, Sune Fallgaard, Fardo, David W., Farotti, Lucia, Fenoglio, Chiara, Fernández-Fuertes, Marta, Ferrari, Raffaele, Ferreira, Catarina B., Ferri, Evelyn, Fin, Bertrand, Fischer, Peter, Fladby, Tormod, Fließbach, Klaus, Fongang, Bernard, Fornage, Myriam, Fortea, Juan, Foroud, Tatiana M., Fostinelli, Silvia, Fox, Nick C., Franco-Macías, Emlio, Bullido, María J, Frank-García, Ana, Froelich, Lutz, Fulton-Howard, Brian, Galimberti, Daniela, García-Alberca, Jose Maria, García-González, Pablo, Garcia-Madrona, Sebastian, Garcia-Ribas, Guillermo, Ghidoni, Roberta, Giegling, Ina, Giorgio, Giaccone, Goate, Alison M., Goldhardt, Oliver, Gomez-Fonseca, Duber, González-Pérez, Antonio, Graff, Caroline, Grande, Giulia, Green, Emma, Grimmer, Timo, Grünblatt, Edna, Grunin, Michelle, Gudnason, Vilmundur, Guetta-Baranes, Tamar, Haapasalo, Annakaisa, Hadjigeorgiou, Georgios, Haines, Jonathan L., Hamilton-Nelson, Kara L., Hampel, Harald, Hanon, Olivier, Hardy, John, Hartmann, Annette M., Hausner, Lucrezia, Harwood, Janet, Heilmann-Heimbach, Stefanie, Helisalmi, Seppo, Heneka, Michael T., Hernández, Isabel, Herrmann, Martin J., Hoffmann, Per, Holmes, Clive, Holstege, Henne, Vilas, Raquel Huerto, Hulsman, Marc, Humphrey, Jack, Biessels, Geert Jan, Jian, Xueqiu, Johansson, Charlotte, Jun, Gyungah R., Kastumata, Yuriko, Kauwe, John, Kehoe, Patrick G., Kilander, Lena, Ståhlbom, Anne Kinhult, Kivipelto, Miia, Koivisto, Anne, Kornhuber, Johannes, Kosmidis, Mary H., Kukull, Walter A., Kuksa, Pavel P., Kunkle, Brian W., Kuzma, Amanda B., Lage, Carmen, Laukka, Erika J., Launer, Lenore, Lauria, Alessandra, Lee, Chien-Yueh, Lehtisalo, Jenni, Lerch, Ondrej, Lleó, Alberto, Longstreth, William, Lopez, Oscar, de Munain, Adolfo Lopez, Love, Seth, Löwemark, Malin, Luckcuck, Lauren, Lunetta, Kathryn L., Ma, Yiyi, Macías, Juan, MacLeod, Catherine A., Maier, Wolfgang, Mangialasche, Francesca, Spallazzi, Marco, Marquié, Marta, Marshall, Rachel, Martin, Eden R., Montes, Angel Martín, Rodríguez, Carmen Martínez, Masullo, Carlo, Mayeux, Richard, Mead, Simon, Mecocci, Patrizia, Medina, Miguel, Meggy, Alun, Mehrabian, Shima, Mendoza, Silvia, Menéndez-González, Manuel, Mir, Pablo, Moebus, Susanne, Mol, Merel, Molina-Porcel, Laura, Montrreal, Laura, Morelli, Laura, Moreno, Fermin, Morgan, Kevin, Mosley, Thomas, Nöthen, Markus M., Muchnik, Carolina, Mukherjee, Shubhabrata, Nacmias, Benedetta, Ngandu, Tiia, Nicolas, Gael, Nordestgaard, Børge G, Olaso, Robert, Orellana, Adelina, Orsini, Michela, Ortega, Gemma, Padovani, Alessandro, Paolo, Caffarra, Papenberg, Goran, Parnetti, Lucilla, Pasquier, Florence, Pastor, Pau, Peloso, Gina, Pérez-Cordón, Alba, Pérez-Tur, Jordi, Pericard, Pierre, Peters, Oliver, Pijnenburg, Yolande A L, Pineda, Juan A., Piñol-Ripoll, Gerard, Pisanu, Claudia, Polak, Thomas, Popp, Julius, Posthuma, Danielle, Priller, Josef, Puerta, Raquel, Quenez, Olivier, Quintela, Inés, Thomassen, Jesper Qvist, Rábano, Alberto, Rainero, Innocenzo, Rajabli, Farid, Ramakers, Inez, Real, Luis M., Reinders, Marcel J T, Reitz, Christiane, Reyes-Dumeyer, Dolly, Ridge, Perry, Riedel-Heller, Steffi, Riederer, Peter, Roberto, Natalia, Rodriguez-Rodriguez, Eloy, Rongve, Arvid, Allende, Irene Rosas, Rosende-Roca, Maitée, Royo, Jose Luis, Rubino, Elisa, Rujescu, Dan, Sáez, María Eugenia, Sakka, Paraskevi, Saltvedt, Ingvild, Sanabria, Ángela, Sánchez-Arjona, María Bernal, Sanchez-Garcia, Florentino, Juan, Pascual Sánchez, Sánchez-Valle, Raquel, Sando, Sigrid Botne, Sarnowski, Chloé, Satizabal, Claudia L., Scamosci, Michela, Scarmeas, Nikolaos, Scarpini, Elio, Scheltens, Philip, Scherbaum, Norbert, Scherer, Martin, Schmid, Matthias, Schneider, Anja, Schott, Jonathan M., Selbæk, Geir, Seripa, Davide, Serrano, Manuel, Sha, Jin, Shadrin, Alexey, Skrobot, Olivia, Slifer, Susan, Snijders, Gijsje J L, Soininen, Hilkka, Solfrizzi, Vincenzo, Solomon, Alina, Song, Yeunjoo, Sorbi, Sandro, Sotolongo-Grau, Oscar, Spalletta, Gianfranco, Spottke, Annika, Squassina, Alessio, Stordal, Eystein, Tartan, Juan Pablo, Tárraga, Lluís, Tesí, Niccolo, Thalamuthu, Anbupalam, Thomas, Tegos, Tosto, Giuseppe, Traykov, Latchezar, Tremolizzo, Lucio, Tybjærg-Hansen, Anne, Uitterlinden, Andre, Ullgren, Abbe, Ulstein, Ingun, Valero, Sergi, Valladares, Otto, Broeckhoven, Christine Van, Vance, Jeffery, Vardarajan, Badri N., van der Lugt, Aad, Dongen, Jasper Van, van Rooij, Jeroen, van Swieten, John, Vandenberghe, Rik, Verhey, Frans, Vidal, Jean-Sébastien, Vogelgsang, Jonathan, Vyhnalek, Martin, Wagner, Michael, Wallon, David, Wang, Li-San, Wang, Ruiqi, Weinhold, Leonie, Wiltfang, Jens, Windle, Gill, Woods, Bob, Yannakoulia, Mary, Zare, Habil, Zhao, Yi, Zhang, Xiaoling, Zhu, Congcong, Zulaica, Miren, Farrer, Lindsay A., Psaty, Bruce M., Ghanbari, Mohsen, Raj, Towfique, Sachdev, Perminder, Mather, Karen, Jessen, Frank, Ikram, M Arfan, de Mendonça, Alexandre, Hort, Jakub, Tsolaki, Magda, Pericak-Vance, Margaret A., Amouyel, Philippe, Williams, Julie, Frikke-Schmidt, Ruth, Clarimon, Jordi, Deleuze, Jean-François, Rossi, Giacomina, Seshadri, Sudha, Andreassen, Ole, Ingelsson, Martin, Hiltunen, Mikko, Sleegers, Kristel, Schellenberg, Gerard D., van Duijn, Cornelia M., Sims, Rebecca, van der Flier, Wiesje M., Ruiz, Agustín, Ramirez, Alfredo, Lambert, Jean-Charles

Externí odkaz: https://hdl.handle.net/11250/3020580

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Autor: Bellenguez C; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Jansen IE; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Kleineidam L; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Moreno-Grau S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, UK., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Campos-Martin R; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Grenier-Boley B; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Andrade V; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Holmans PA; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Boland A; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Damotte V; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Costa MR; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., de Rojas I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Yaqub A; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Prokic I; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Chapuis J; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Ahmad S; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; LACDR, Leiden, the Netherlands., Giedraitis V; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Aarsland D; Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.; Institute of Psychiatry, Psychology & Neuroscience, London, UK., Garcia-Gonzalez P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Abdelnour C; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alarcón-Martín E; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain., Alcolea D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Alegret M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alvarez I; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Armstrong NJ; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Tsolaki A; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Antúnez C; Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Appollonio I; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Arcaro M; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy., Archetti S; Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy., Pastor AA; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Athanasiu L; NORMENT Centre, University of Oslo, Oslo, Norway., Bailly H; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Baquero M; Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Unit of Neurology, University of Parma and AOU, Parma, Italy.; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Beiser A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pastor AB; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Below JE; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Benchek P; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Berr C; Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France., Besse C; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Binetti G; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Bizarro A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Blesa R; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Boada M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Borroni B; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Boschi S; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy., Bossù P; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Bråthen G; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Bresner C; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Brookes KJ; Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Brusco LI; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina.; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Buiza-Rueda D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Bûrger K; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Burholt V; Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.; Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand., Bush WS; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Calero M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.; UFIEC, Instituto de Salud Carlos III, Madrid, Spain., Cantwell LB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chene G; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Chung J; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Cuccaro ML; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Carracedo Á; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain., Cecchetti R; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Cervera-Carles L; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Charbonnier C; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Chen HH; Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA., Chillotti C; Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy., Ciccone S; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Claassen JAHR; Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands., Clark C; Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland., Conti E; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy., Corma-Gómez A; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Costantini E; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Custodero C; University of Bari, 'A. Moro', Bary, Italy., Daian D; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Daniele A; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Dardiotis E; School of Medicine, University of Thessaly, Larissa, Greece., Dartigues JF; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., de Deyn PP; Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands., de Paiva Lopes K; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Debette S; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Del Ser T; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Denning N; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., DeStefano A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Diehl-Schmid J; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Diez-Fairen M; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Rossi PD; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Djurovic S; NORMENT Centre, University of Oslo, Oslo, Norway., Duron E; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Düzel E; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dufouil C; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Eiriksdottir G; Icelandic Heart Association, Kopovagur, Iceland., Engelborghs S; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel, Brussels, Belgium., Escott-Price V; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Espinosa A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ewers M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fabrizio T; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Farotti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Fenoglio C; University of Milan, Milan, Italy., Fernández-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Ferrari R; Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Ferreira CB; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Ferri E; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Fin B; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Fischer P; Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria., Fladby T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fließbach K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Fongang B; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Fornage M; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Fortea J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fostinelli S; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Fox NC; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Franco-Macías E; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Bullido MJ; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain., Frank-García A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Froelich L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Fulton-Howard B; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Galimberti D; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., García-Alberca JM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., García-González P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Garcia-Madrona S; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Giegling I; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Giorgio G; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Goate AM; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goldhardt O; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Gomez-Fonseca D; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., González-Pérez A; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Graff C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Grande G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Green E; Institute of Public Health, University of Cambridge, Cambridge, UK., Grimmer T; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Grunin M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Gudnason V; Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Guetta-Baranes T; Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK., Haapasalo A; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hadjigeorgiou G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Haines JL; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hamilton-Nelson KL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Hampel H; GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Hanon O; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Hardy J; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Hartmann AM; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Harwood J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Helisalmi S; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Heneka MT; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Hernández I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Herrmann MJ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Holmes C; Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK., Holstege H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Vilas RH; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Hulsman M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Humphrey J; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Biessels GJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands., Jian X; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Johansson C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Jun GR; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Kastumata Y; Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Kauwe J; Department of Biology, Brigham Young University, Provo, UT, USA., Kehoe PG; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kilander L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Ståhlbom AK; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Kivipelto M; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden., Koivisto A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Kosmidis MH; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kuksa PP; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kunkle BW; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Kuzma AB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lage C; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Laukka EJ; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Stockholm Gerontology Research Center, Stockholm, Sweden., Launer L; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA., Lauria A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Lee CY; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lehtisalo J; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Lerch O; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia., Lleó A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Longstreth W Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Lopez O; Framingham Heart Study, Framingham, MA, USA., de Munain AL; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Love S; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Löwemark M; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Luckcuck L; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Lunetta KL; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Ma Y; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Neurology, Columbia University, New York, NY, USA., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., MacLeod CA; School of Health Sciences, Bangor University, Bangor, UK., Maier W; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Mangialasche F; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Spallazzi M; Unit of Neurology, University of Parma and AOU, Parma, Italy., Marquié M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marshall R; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Montes AM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Rodríguez CM; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA., Mead S; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Medina M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Meggy A; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Mendoza S; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., Menéndez-González M; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Mir P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Mol M; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Molina-Porcel L; Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain., Montrreal L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Morelli L; Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina., Moreno F; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Morgan K; Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK., Mosley T; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Muchnik C; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Ngandu T; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Nicolas G; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Olaso R; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Orellana A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Orsini M; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ortega G; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Padovani A; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Paolo C; DIMEC, University of Parma, Parma, Italy., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Pasquier F; Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France., Pastor P; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Peloso G; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pérez-Cordón A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Pérez-Tur J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Institut de Biomedicina de València-CSIC CIBERNED, València, Spain.; Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain., Pericard P; US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France., Peters O; Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Polak T; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Popp J; CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany., Puerta R; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Quenez O; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Quintela I; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Thomassen JQ; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Rábano A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Rainero I; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Rajabli F; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Ramakers I; Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Reinders MJT; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.; Taub Institute, Columbia University, New York, NY, USA., Reyes-Dumeyer D; Department of Neurology, Columbia University, New York, NY, USA.; Taub Institute, Columbia University, New York, NY, USA., Ridge P; Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Riederer P; Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany., Roberto N; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Rodriguez-Rodriguez E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Rongve A; Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.; Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway., Allende IR; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Rosende-Roca M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain., Rubino E; Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Sakka P; Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece., Saltvedt I; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Sanabria Á; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sánchez-Arjona MB; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain., Juan PS; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Sánchez-Valle R; Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain., Sando SB; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway., Sarnowski C; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Satizabal CL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Scamosci M; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Scarmeas N; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Scarpini E; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Scherbaum N; LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Schneider A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Selbæk G; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Serrano M; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain., Sha J; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shadrin AA; NORMENT Centre, University of Oslo, Oslo, Norway., Skrobot O; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Slifer S; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Snijders GJL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland., Solfrizzi V; University of Bari, 'A. Moro', Bary, Italy., Solomon A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Song Y; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Sotolongo-Grau O; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Spottke A; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Stordal E; Department of Psychiatry, Namsos Hospital, Namsos, Norway., Tartan JP; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Tárraga L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Tesí N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Thomas T; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Tosto G; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Traykov L; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Tremolizzo L; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Tybjærg-Hansen A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Uitterlinden A; Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands., Ullgren A; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Ulstein I; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Valero S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valladares O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Broeckhoven CV; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Vance J; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., van der Lugt A; Department of Neurology, ErasmusMC, Rotterdam, the Netherlands., Dongen JV; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., van Rooij J; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.; Department of Neurology, ErasmusMC, Rotterdam, the Netherlands., van Swieten J; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.; Neurology Department, University Hospitals Leuven, Leuven, Belgium., Verhey F; Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands., Vidal JS; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Vogelgsang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA., Vyhnalek M; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia., Wagner M; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Wallon D; Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Wang LS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wang R; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Weinhold L; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Medical Science Department, iBiMED, Aveiro, Portugal., Windle G; School of Health Sciences, Bangor University, Bangor, UK., Woods B; School of Health Sciences, Bangor University, Bangor, UK., Yannakoulia M; Department of Nutrition and Diatetics, Harokopio University, Athens, Greece., Zare H; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Zhao Y; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zhang X; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zhu C; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zulaica M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain., Farrer LA; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Psaty BM; Framingham Heart Study, Framingham, MA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Health Service, University of Washington, Seattle, WA, USA., Ghanbari M; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Raj T; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sachdev P; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Mather K; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Jessen F; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Hort J; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia., Tsolaki M; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Pericak-Vance MA; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Amouyel P; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Williams J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Frikke-Schmidt R; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Clarimon J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Deleuze JF; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Rossi G; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Seshadri S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway., Ingelsson M; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Hiltunen M; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, UK., Sims R; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Ruiz A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ramirez A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Lambert JC; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.

Publikováno v: Nature genetics [Nat Genet] 2022 Apr; Vol. 54 (4), pp. 412-436. Date of Electronic Publication: 2022 Apr 04.