Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rodolphe Alves de Sousa"'
Publikováno v:
BioTech, Vol 12, Iss 3, p 57 (2023)
Targeted protein degradation is an attractive technology for cancer treatment due to its ability to overcome the unpredictability of the small molecule inhibitors that cause resistance mutations. In recent years, various targeted protein degradation
Externí odkaz:
https://doaj.org/article/4da46726c09b46afb5e379e013fcb943
Autor:
Anas Allam, Laure Maigre, Julia Vergalli, Estelle Dumont, Bertrand Cinquin, Rodolphe Alves de Sousa, Jelena Pajovic, Elizabeth Pinet, Nikaia Smith, Jean-Philippe Herbeuval, Matthieu Réfrégiers, Isabelle Artaud, Jean-Marie Pagès
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract A main challenge in chemotherapy is to determine the in cellulo parameters modulating the drug concentration required for therapeutic action. It is absolutely urgent to understand membrane permeation and intracellular concentration of antibi
Externí odkaz:
https://doaj.org/article/ca80691df79d435fac589a85f21b0920
Autor:
Melkon Iradyan, Nina Iradyan, Philippe Hulin, Artur Hambardzumyan, Aram Gyulkhandanyan, Rodolphe Alves de Sousa, Assia Hessani, Christos Roussakis, Guillaume Bollot, Cyril Bauvais, Vehary Sakanyan
Publikováno v:
Cancers, Vol 11, Iss 8, p 1094 (2019)
Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations
Externí odkaz:
https://doaj.org/article/69abee0c9bfe4eb5b860c6e1d844d705
Autor:
Stéphanie Arnould, Laura Ermellino, Jean-Philippe Herbeuval, Claude Sardet, Rodolphe Alves de Sousa, Nicolas Pietrancosta, Anna Hovhannisyan, Sébastien Nisole, Olivier Diaz, Simon Hayek, Pierre-Olivier Vidalain, Julien Dairou, Gagik Melikyan, Nassima Bekaddour, Vincent Lotteau, Enzo Tramontano
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
International audience; There is an increasing interest in the field of cancer therapy for small compounds targeting pyrimidine biosynthesis, and in particular dihydroorotate dehydrogenase (DHODH), the fourth enzyme of this metabolic pathway. Three a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165cc82b4bd18dd1566d0212c17f0b74
https://hal.archives-ouvertes.fr/hal-02372490/file/P1788-Manuscript-Revised-Final.pdf
https://hal.archives-ouvertes.fr/hal-02372490/file/P1788-Manuscript-Revised-Final.pdf
Autor:
Jean-Philippe Herbeuval, Rodolphe Alves de Sousa, Nicolas Pietrancosta, Simon Hayek, Robert Barouki, Pierre-Olivier Vidalain
Publikováno v:
Virologie. 22:27-40
Autor:
Estelle Dumont, Julia Vergalli, Rodolphe Alves de Sousa, Laure Maigre, Isabelle Artaud, Jean-Marie Pagès, Anas Allam
Publikováno v:
European Journal of Medicinal Chemistry. 127:748-756
Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphili
Autor:
Teodoro Zornoza, Franck Louis, Sara Rezai Amin, Rodolphe Alves de Sousa, Patrick M. Dansette, Carole Gruszczynski, Sophie Gautron, Vincent Vialou, Alejandro Orrico-Sanchez, Basile Coutens, Nicolas Pietrancosta, Francine Acher, Bruno P. Guiard, Laetitia Chausset-Boissarie, Assia Hessani, Bruno Giros
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2019, ⟨10.1038/s41380-019-0548-4⟩
Molecular Psychiatry, 2020, 25 (6), pp.1245-1259. ⟨10.1038/s41380-019-0548-4⟩
Molecular Psychiatry, Nature Publishing Group, 2019, ⟨10.1038/s41380-019-0548-4⟩
Molecular Psychiatry, 2020, 25 (6), pp.1245-1259. ⟨10.1038/s41380-019-0548-4⟩
International audience; Current antidepressants act principally by blocking monoamine reuptake by high-affinity transporters in the brain. However, these antidepressants show important shortcomings such as slow action onset and limited efficacy in ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a2c1742a246517d0a349fbbcb63e7
https://hal.archives-ouvertes.fr/hal-02351247
https://hal.archives-ouvertes.fr/hal-02351247
Autor:
Oumaïma Ibrahim-Granet, Daniel Mansuy, Olivier Helynck, Laurence du Merle, Rocío Vicentefranqueira, Grégory Jouvion, Jean-Paul Latgé, Frédéric Buron, Jean-Marc Cavaillon, Hélène Munier-Lehmann, Paris Laskaris, Franck Suzenet, José Antonio Calera, Rodolphe Alves de Sousa
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Antimicrobial Agents and Chemotherapy, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Antimicrobial Agents and Chemotherapy, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Aspergillus fumigatus can cause pulmonary aspergillosis in immunocompromised patients and is associated with a high mortality rate due to a lack of reliable treatment options. This opportunistic pathogen requires zinc in order to grow and cause disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc6264a48be262fe49b542189b82d94
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968421/file/AAC.02510-17.full.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968421/file/AAC.02510-17.full.pdf
Autor:
Jean-Philippe Herbeuval, Rodolphe Alves de Sousa, Robert Barouki, Nicolas Pietrancosta, Simon Hayek, Pierre-Olivier Vidalain
Publikováno v:
Virologie
Virologie, John Libbey Eurotext 2018, 22 (1), pp.1-13. ⟨10.1684/vir.2018.0717⟩
Virologie, John Libbey Eurotext 2018, 22 (1), pp.1-13. ⟨10.1684/vir.2018.0717⟩
Environmental pollution is of concern to civil society and as the problem intensifies, there is increasing pressure on politicians and polluters to assess and mitigate this risk. In addition, the emergence (or re-emergence) of viral pathologies such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d58d436c88f0da29934c6df71207a92
https://hal.archives-ouvertes.fr/hal-02351261
https://hal.archives-ouvertes.fr/hal-02351261
Autor:
Thierry Meinnel, Karim Hamiche, Rodolphe Alves de Sousa, Carmela Giglione, Laure Maigre, Alexis Denis, Sonia Fieulaine, Jean-Michel Bolla, Isabelle Artaud, Mickael Alimi, Abbass Taleb, Jean-Marie Pagès
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩
Scientific Reports, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩
Scientific Reports, 2017, 7, pp.39365. ⟨10.1038/srep39365⟩
Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae