Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Rodolphe, Hajj"'
1
Combinational Drug Repurposing from Genetic Networks Applied to Alzheimer’s Disease
Autor: Serguei, Nabirotchkin, Jan, Bouaziz, Fabrice, Glibert, Jonas, Mandel, Julie, Foucquier, Rodolphe, Hajj, Noëlle, Callizot, Nathalie, Cholet, Mickaël, Guedj, Daniel, Cohen
Publikováno v: Journal of Alzheimer's Disease. 88:1585-1603
Background: Human diseases are multi-factorial biological phenomena resulting from perturbations of numerous functional networks. The complex nature of human diseases explains frequently observed marginal or transitory efficacy of mono-therapeutic in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689c941909510a2251ed0bd5d8421b6
https://doi.org/10.3233/jad-220120
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2
Akademický článek
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A).
Autor: Thomas Prukop, Jan Stenzel, Stephanie Wernick, Theresa Kungl, Magdalena Mroczek, Julia Adam, David Ewers, Serguei Nabirotchkin, Klaus-Armin Nave, Rodolphe Hajj, Daniel Cohen, Michael W Sereda
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0209752 (2019)
The most common type of Charcot-Marie-Tooth disease is caused by a duplication of PMP22 leading to dysmyelination, axonal loss and progressive muscle weakness (CMT1A). Currently, no approved therapy is available for CMT1A patients. A novel polytherap
Externí odkaz: https://doaj.org/article/54beea3e92d54d269e68e88861e3c885
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3
Combination of acamprosate and baclofen (PXT864) as a potential new therapy for amyotrophic lateral sclerosis
Autor: Julien Laffaire, Serguei Nabirotchkin, Noelle Callizot, Philippe Rinaudo, Peter Schmitt, Daniel Cohen, Lydie Boussicault, Rodolphe Hajj
Publikováno v: Journal of Neuroscience Research
There is currently no therapy impacting the course of amyotrophic lateral sclerosis (ALS). The only approved treatments are riluzole and edaravone, but their efficacy is modest and short‐lasting, highlighting the need for innovative therapies. We p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54574081e684e3891ff9d7410666c3df
https://doi.org/10.1002/jnr.24714
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4
An overview of ongoing clinical trials assessing pharmacological therapeutic strategies to manage chemotherapy‐induced peripheral neuropathy, based on preclinical studies in rodent models
Autor: Rodolphe Hajj, Hichem Bouchenaki, Aurore Danigo, Franck Sturtz, Laurent Magy, Claire Demiot
Publikováno v: Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, 35 (3), pp.506-523. ⟨10.1111/fcp.12617⟩
International audience; Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect induced by a variety of chemotherapeutic agents. Symptoms are mainly sensory: pain, tingling, numbness, and temperature sensitivity. They m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808266cc7d4671762744dca73307acac
https://hal.archives-ouvertes.fr/hal-03269233
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7
Les traitements pharmacologiques des douleurs neuropathiques
Autor: Rodolphe Hajj, Mélina Bégou, Laurent Magy, Hichem Bouchenaki, Claire Demiot
Publikováno v: Thérapie
Thérapie, EDP Sciences, 2019, 74 (6), pp.633-643. ⟨10.1016/j.therap.2019.04.003⟩
Thérapie, EDP Sciences-Depuis 2016, la revue Thérapie n’est plus publiée par EDP Sciences.> Therapies (Elsevier), 2019, 74 (6), pp.633-643. ⟨10.1016/j.therap.2019.04.003⟩
International audience; Neuropathic pain is defined as pain caused by a lesion or a disease affecting the somatosensory nervous system. Development of neuropathic pain is induced by many pathophysiological mechanisms affecting pain pathways. Neuropat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34dc46e5a19fa7cc06b244c5e2aa830
https://hal.archives-ouvertes.fr/hal-03332441
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8
Next-generation drug repurposing using human genetics and network biology
Autor: Philippe Rinaudo, Serguei Nabirotchkin, Jinchao Yu, Alex E. Peluffo, Rodolphe Hajj, Daniel Cohen
Publikováno v: Current opinion in pharmacology. 51
Drug repurposing has attracted increased attention, especially in the context of drug discovery rates that remain too low despite a recent wave of approvals for biological therapeutics (e.g. gene therapy). These new biological entities-based treatmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4deef1e97a3bc5677a20a13dda627848
https://pubmed.ncbi.nlm.nih.gov/31982325
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9
[Pharmacological management of neuropathic pain]
Autor: Hichem, Bouchenaki, Mélina, Bégou, Laurent, Magy, Rodolphe, Hajj, Claire, Demiot
Publikováno v: Therapie. 74(6)
Neuropathic pain is defined as pain caused by a lesion or a disease affecting the somatosensory nervous system. Development of neuropathic pain is induced by many pathophysiological mechanisms affecting pain pathways. Neuropathic pain has diverse ori
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::339c27204e7cb30fbe2885ca8eba33d8
https://pubmed.ncbi.nlm.nih.gov/31097329
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10
Molecular changes in the postmortem parkinsonian brain
Autor: Anthony H.V. Schapira, Damien Toulorge, Rodolphe Hajj
Publikováno v: Journal of Neurochemistry. 139:27-58
Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become clear that its etiological basis is broad. Post-mortem brain analysis, despite i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878bd002f51b082e0773542b4ec8b76f
https://doi.org/10.1111/jnc.13696
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