Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity

Autor: Caroline Stekelenburg, Jean-Louis Blouin, Federico Santoni, Norann Zaghloul, Elisabeth A. O’Hare, Rodolphe Dusaulcy, Pierre Maechler, Valerie M. Schwitzgebel

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract We identified two NEXMIF variants in two unrelated individuals with non-autoimmune diabetes and autistic traits, and investigated the expression of Nexmif in mouse and human pancreas and its function in pancreatic beta cells in vitro and in

Externí odkaz: https://doaj.org/article/34e22b0932044412902bc1caf1277407

Sphingosine‐1‐phosphate as a key player of insulin secretion induced by high‐density lipoprotein treatment

Autor: Marie‐Claude Brulhart‐Meynet, Aurélien Thomas, Jonathan Sidibé, Florian Visentin, Rodolphe Dusaulcy, Valérie Schwitzgebel, Zoltan Pataky, Jacques Philippe, Nicolas Vuilleumier, Richard W. James, Yvan Gosmain, Miguel A. Frias

Publikováno v: Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)

Abstract Beta cell failure is one of the most important features of type 2 diabetes mellitus (T2DM). High‐density lipoprotein (HDL) has been proposed to improve β‐cell function. However, the mechanisms involved in this process are still poorly u

Externí odkaz: https://doaj.org/article/162fc634a107485baf6cbfe38cfba621

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Autor: Rodolphe Dusaulcy, Chloé Rancoule, Sandra Grès, Estelle Wanecq, André Colom, Charlotte Guigné, Laurens A. van Meeteren, Wouter H. Moolenaar, Philippe Valet, Jean Sébastien Saulnier-Blache

Publikováno v: Journal of Lipid Research, Vol 52, Iss 6, Pp 1247-1255 (2011)

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific c

Externí odkaz: https://doaj.org/article/e5ac99397ff44ed8be0927e7dbf10e8b

Sphingosine‐1‐phosphate as a key player of insulin secretion induced by high‐density lipoprotein treatment

Autor: Zoltan Pataky, Rodolphe Dusaulcy, Richard W. James, Nicolas Vuilleumier, Jacques Philippe, Miguel Frias, Valerie M. Schwitzgebel, Jonathan Sidibé, Florian Visentin, Aurélien Thomas, Yvan Gosmain, Marie-Claude Brulhart-Meynet

Publikováno v: Physiological Reports
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Physiological reports, vol. 9, no. 6, pp. e14786
Physiological reports, Vol. 9, No 6 (2021) P. e14786

Beta cell failure is one of the most important features of type 2 diabetes mellitus (T2DM). High‐density lipoprotein (HDL) has been proposed to improve β‐cell function. However, the mechanisms involved in this process are still poorly understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18aafebc1a234b608f3aad5f52b836ba
https://doi.org/10.14814/phy2.14786

Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

Autor: Jakob S. Hansen, Michel Pinget, Bente Klarlund Pedersen, Cédric Howald, Peter Plomgaard, Emmanouil T. Dermitzakis, Sabine Rütti, Karim Bouzakri, Rodolphe Dusaulcy

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Rutti, S, Dusaulcy, R, Hansen, J S, Howald, C, Dermitzakis, E T, Pedersen, B K, Pinget, M, Plomgaard, P & Bouzakri, K 2018, ' Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines ', Scientific Reports, vol. 8, 10072 . https://doi.org/10.1038/s41598-018-28117-2
Scientific Reports
Scientific Reports, Vol. 8, No 1 (2018) P. 10072

Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb3776ec1a6ed76a6813582cbcd197
http://link.springer.com/article/10.1038/s41598-018-28117-2