Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Rodolfo Negri"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6900 (2024)
Histone lysine demethylases (KDMs) play an essential role in biological processes such as transcription regulation, RNA maturation, transposable element control, and genome damage sensing and repair. In most cases, their action requires catalytic act
Externí odkaz:
https://doaj.org/article/47e064d09e5044e9bc92e5441e761afa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/328747785d754fe690b33627b8f2416f
Autor:
Elena Di Nisio, Svetlana Danovska, Livia Condemi, Angela Cirigliano, Teresa Rinaldi, Valerio Licursi, Rodolfo Negri
Publikováno v:
Metabolites, Vol 13, Iss 4, p 507 (2023)
We show that in S. cerevisiae the metabolic diauxic shift is associated with a H3 lysine 4 tri-methylation (H3K4me3) increase which involves a significant fraction of transcriptionally induced genes which are required for the metabolic changes, sugge
Externí odkaz:
https://doaj.org/article/0f1bd4c611a5453b98f9e92df21b2654
Autor:
Chiara Frigerio, Elena Di Nisio, Michela Galli, Chiara Vittoria Colombo, Rodolfo Negri, Michela Clerici
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3248 (2023)
DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic consequences for genome stability if not properly repaired. DSBs can be repaired by either non-homologous end joining (NHEJ) or homologous recombination (HR). The choi
Externí odkaz:
https://doaj.org/article/ae64cf5918384d67a32d88d0b84580e3
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/e3ead19f1dd34beea8dfc1d25b91bd61
Autor:
Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 129-138 (2020)
The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medi
Externí odkaz:
https://doaj.org/article/40e1c1c58ff541c6906128d70d7d2c1e
Autor:
Wei Wang, Elena Di Nisio, Valerio Licursi, Emanuele Cacci, Giuseppe Lupo, Zaal Kokaia, Sergio Galanti, Paolo Degan, Sara D’Angelo, Patrizio Castagnola, Sara Tavella, Rodolfo Negri
Publikováno v:
Life, Vol 12, Iss 11, p 1827 (2022)
We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine appar
Externí odkaz:
https://doaj.org/article/068c6363fc754d738bc440627f36ee8c
Autor:
Marilena P. Etna, Martina Severa, Valerio Licursi, Manuela Pardini, Melania Cruciani, Fabiana Rizzo, Elena Giacomini, Gianfranco Macchia, Orazio Palumbo, Raffaella Stallone, Massimo Carella, Mark Livingstone, Rodolfo Negri, Sandra Pellegrini, Eliana M. Coccia
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion. Here, the immunostimul
Externí odkaz:
https://doaj.org/article/eb748d7cd1c049debd23f736020b2119
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Eukaryotic genomes are wrapped around nucleosomes and organized into different levels of chromatin structure. Chromatin organization has a crucial role in regulating all cellular processes involving DNA-protein interactions, such as DNA transcription
Externí odkaz:
https://doaj.org/article/934311716639492cae96953697104f8f
Autor:
Noemi A. Guadagno, Claudia Moriconi, Valerio Licursi, Emanuela D'Acunto, Paola S. Nisi, Nicoletta Carucci, Antonella De Jaco, Emanuele Cacci, Rodolfo Negri, Giuseppe Lupo, Elena Miranda
Publikováno v:
Neurobiology of Disease, Vol 103, Iss , Pp 32-44 (2017)
The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity. The dementia FENIB is caused by polymerisation
Externí odkaz:
https://doaj.org/article/40f41ac322b146d2a0e0a47bb55bb048