Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Rodolfo Madrid"'
Autor:
Rodolfo Madrid, Ricardo Piña, Gonzalo Ugarte, Richard Pino, Katherine Valdebenito, Camilo Guevara, Sofía Romero, Ana Gomez Del Campo, Victor Cornejo, Maria Pertusa
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S695-S696 (2023)
Externí odkaz:
https://doaj.org/article/fafa75f7f3d5473eaa01fc48beabf22a
Autor:
Maria Pertusa, Carolina González, Bastián Rivera, Claudio Moreno, Felix Viana, Rodolfo Madrid
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S707-S708 (2023)
Externí odkaz:
https://doaj.org/article/74002af9c90e43e496a6a05e884b1560
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Cold thermoreceptor neurons detect temperature drops with highly sensitive molecular machinery concentrated in their peripheral free nerve endings. The main molecular entity responsible for cold transduction in these neurons is the thermo-TRP channel
Externí odkaz:
https://doaj.org/article/310524fb54d24cf48268fd4e36833175
Autor:
Erick Olivares, Simón Salgado, Jean Paul Maidana, Gaspar Herrera, Matías Campos, Rodolfo Madrid, Patricio Orio
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139314 (2015)
Cold-sensitive nerve terminals (CSNTs) encode steady temperatures with regular, rhythmic temperature-dependent firing patterns that range from irregular tonic firing to regular bursting (static response). During abrupt temperature changes, CSNTs show
Externí odkaz:
https://doaj.org/article/8e62f5c28fde473db2719c556a75e7f7
Autor:
Félix Viana, Patricio Orio, Kang Sik Park, Jorge Fernández-Trillo, Boris Lavanderos, María Pertusa, Ji Yeon Hwang, Claudio Moreno, Bastián Rivera, Rodolfo Madrid
Publikováno v:
J Neurosci
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
In mammals, environmental cold sensing conducted by peripheral cold thermoreceptor neurons mostly depends on TRPM8, an ion channel that has evolved to become the main molecular cold transducer. This TRP channel is activated by cold, cooling compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a30608e0aa60a7b8ec17e638df879f
http://hdl.handle.net/10261/267479
http://hdl.handle.net/10261/267479
Autor:
Cristian Arredondo, Carolina Cefaliello, Agnieszka Dyrda, Nur Jury, Pablo Martinez, Iván Díaz, Armando Amaro, Helene Tran, Danna Morales, Maria Pertusa, Lorelei Stoica, Elsa Fritz, Daniela Corvalán, Sebastián Abarzúa, Maxs Méndez-Ruette, Paola Fernández, Fabiola Rojas, Meenakshi Sundaram Kumar, Rodrigo Aguilar, Sandra Almeida, Alexandra Weiss, Fernando J. Bustos, Fernando González-Nilo, Carolina Otero, Maria Florencia Tevy, Daryl A. Bosco, Juan C. Sáez, Thilo Kähne, Fen-Biao Gao, James D. Berry, Katharine Nicholson, Miguel Sena-Esteves, Rodolfo Madrid, Diego Varela, Martin Montecino, Robert H. Brown, Brigitte van Zundert
Publikováno v:
Neuron. 110:1656-1670.e12
Non-cell-autonomous mechanisms contribute to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), in which astrocytes release unidentified factors that are toxic to motoneurons (MNs). We report her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0008063d400e3b00a4aa9c2dc5dafab6
https://doi.org/10.1016/j.neuron.2022.02.010
https://doi.org/10.1016/j.neuron.2022.02.010
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4420, p 4420 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4420, p 4420 (2020)
TRPM8 is the main molecular entity responsible for cold sensing. This polymodal ion channel is activated by cold, cooling compounds such as menthol, voltage, and rises in osmolality. In corneal cold thermoreceptor neurons (CTNs), TRPM8 expression det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ce2441634f1d94561d72b7ca09a19c
Autor:
Rodolfo Madrid, María Pertusa
Publikováno v:
Temperature. 4:346-349
Exposure of body surface to temperature reductions evokes a wide variety of cold sensations, from comfortable cooling to intense pain depending on the intensity, speed and duration of the stimulus....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::257ac23443e026b4279390bfa540863b
https://doi.org/10.1080/23328940.2017.1341968
https://doi.org/10.1080/23328940.2017.1341968
Autor:
Juan Bacigalupo, Patricio Orio, Ricardo Piña, Matías Campos, Rodolfo Madrid, Carlos Belmonte, Erick Olivares, Gonzalo Ugarte, Almudena Íñigo-Portugués
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The cornea is extensively innervated by trigeminal ganglion cold thermoreceptor neurons expressing TRPM8 (transient receptor potential cation channel subfamily M member 8). These neurons respond to cooling, hyperosmolarity and wetness of the corneal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8e2e27d1753d254870281b6c104b36
http://hdl.handle.net/10261/217947
http://hdl.handle.net/10261/217947
Autor:
Ricardo Piña, Pablo Rozas, Ashok B. Kulkarni, Rodolfo Madrid, Christian Gonzalez-Billault, María Pertusa, Andrew Cho, Pablo Lazcano, Elias Utreras, Anita Terse
Publikováno v:
Pain
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
We reported earlier that TNF-α, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and recently found to be involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172fd9bee8bb523223d7d668794c78e4
https://doi.org/10.1097/j.pain.0000000000000527
https://doi.org/10.1097/j.pain.0000000000000527