Výsledky vyhledávání - "Rodolfo M. Alarcon"

In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection

Autor: W. Timothy Jenkins, Kevin Jenkins, Amit Maity, Monika Kumanova, Panagiotis Alexiou, Diane Marotta, Rodolfo M. Alarcon, Constantinos Koumenis, Artemis G. Hatzigeorgiou, Donald Baldwin, Jayashree Karar, Sydney M. Evans, Cameron J. Koch, John W. Tobias

Publikováno v: Cancer Research. 71:779-789

Hypoxia is a key determinant of tumor aggressiveness, yet little is known regarding hypoxic global gene regulation in vivo. We used the hypoxia marker EF5 coupled with laser-capture microdissection to isolate RNA from viable hypoxic and normoxic regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd0bba3084ef4f00c98b81ed04d2f96
https://doi.org/10.1158/0008-5472.can-10-3061

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A role ofmiR-27in the regulation of adipogenesis

Autor: Zhanguo Gao, Qun Lin, Zhong Yun, Rodolfo M. Alarcon, Jianping Ye

Publikováno v: FEBS Journal. 276:2348-2358

MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis in adult tissues. Recently, miRNAs have emerged as a class of epigenetic regulators of metabolism and energy homeostasis. We ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce33af89c1020ba1e5147196414ebf2
https://doi.org/10.1111/j.1742-4658.2009.06967.x

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Oxygen and Cell Fate Decisions

Autor: Zhong Yun, Yuri Kim, Qun Lin, Rodolfo M. Alarcon

Publikováno v: Gene Regulation and Systems Biology, Vol 2, Pp 43-51 (2008)
Gene Regulation and Systems Biology
Gene Regulation and Systems Biology, Vol 2 (2008)

Molecular oxygen has been known to play a critical role in a wide range of biological processes including glycolysis, mitochondrial respiration, angiogenesis, pulmonary functions, and cardiovascular activities. An emerging theme has developed in rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1b512f0defeda4a613cca74b979a1a
http://la-press.com/article.php?article_id=550

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p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts

Autor: Amato J. Giaccia, Susan J. Knox, Rodolfo M. Alarcon, Brent A. Rupnow

Publikováno v: Cell Death & Differentiation. 5:141-147

Deregulated c-Myc expression leads to a cellular state where proliferation and apoptosis are equally favored depending on the cellular microenvironment. Since the apoptotic sensitivity of many cells is influenced by the status of the p53 tumor suppre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1fe6a7bac1bf4f1748cae7872802b5
https://doi.org/10.1038/sj.cdd.4400328

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Genetic Determinants That Influence Hypoxia-Induced Apoptosis

Autor: Nicholas C. Denko, Rodolfo M. Alarcon, Amato J. Giaccia

Publikováno v: The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity: Novartis Foundation Symposium 240

The p53 tumour suppressor gene is capable of activating both death receptor and mitochondrial-signalled forms of apoptotic cell death in response to diverse stimuli. Studies have suggested that impairment of the mitochondrial-signalled Apaf/caspase 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37f9fa008fe6125f974c8596485fa573
https://doi.org/10.1002/0470868716.ch8

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Emerging tick-borne disease in African vipers caused by a Cowdria-like organism

Autor: Rodolfo M. Alarcon, Lucille J.V. Stribling, Jill E. Parker, Yvette B. Gonzalez, Carrie J. Andrews, Johnathan L. Kiel, Jeeva Vivekananda

Publikováno v: Annals of the New York Academy of Sciences. 1081

Heartwater is a tick-borne infectious disease caused by the rickettsial organism Cowdria ruminantium, currently Ehrlichia ruminantium. It poses an imminent threat to the Western Hemisphere, where it could cause mortality in cattle and other ruminant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfe98ce2d873bf8ef0f2bb21a4fb35f
https://pubmed.ncbi.nlm.nih.gov/17135546

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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation

Autor: William H. Hoffman, Scott W. Lowe, Jennifer Derr, Michael B. Kastan, Yoichi Taya, Constantinos Koumenis, Amato J. Giaccia, Patrick D. Sutphin, Rodolfo M. Alarcon, Maureen E. Murphy, Ester M. Hammond

Publikováno v: Molecular and cellular biology. 21(4)

Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4c90f6e15b943b581859c8be503d30
https://pubmed.ncbi.nlm.nih.gov/11158315

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Abstract 5004: In vivo profiling of hypoxic mRNA and miRNA expression in gliomas and head and neck tumors

Autor: Cameron J. Koch, Donald A. Baldwin, Amit Maity, Monika Kumanova, Diane Marotta, Jayashree Karar, Kevin Jenkins, Rodolfo M. Alarcon, Artemis G. Hatzigeorgiou, Panagiotis Alexiou, W. Timothy Jenkins, Constantinos Koumenis, Sydney M. Evans, John W. Tobias

Publikováno v: Cancer Research. 71:5004-5004

Hypoxia plays a key role in tumor aggressiveness and radiation resistance, yet little is known regarding hypoxic global gene regulation in vivo. Although the regulation of mRNA and miRNA expression by hypoxia has been investigated in isolation in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b7214f7e21d74c7d32ed889b7e2f1b
https://doi.org/10.1158/1538-7445.am2011-5004

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