Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rodolfo E. De La Vega"'
Autor:
Aysegul Atasoy-Zeybek, Michael J. Coenen, Gresin P. Hawse, Delphine Logeart-Avramoglou, Christopher H. Evans, Rodolfo E. De La Vega
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 350-363 (2023)
Bone morphogenetic protein-2 (BMP-2) is an osteogenic protein used clinically to enhance bone healing. However, it must be applied in very high doses, causing adverse side effects and increasing costs while providing only incremental benefit. Preclin
Externí odkaz:
https://doaj.org/article/a6616c8594034237bd2d18ec1d533163
Autor:
Carlos Julio Peniche Silva, Rodolfo E. De La Vega, Joseph Panos, Virginie Joris, Christopher H. Evans, Elizabeth R. Balmayor, Martijn van Griensven
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8556 (2023)
MicroRNAs (miRNAs) are short non-coding RNA sequences with the ability to inhibit the expression of a target mRNA at the post-transcriptional level, acting as modulators of both the degenerative and regenerative processes. Therefore, these molecules
Externí odkaz:
https://doaj.org/article/3c7ae3acef324e55a0d64a217a13bdf3
Autor:
Christopher V. Nagelli, Rodolfo E. De La Vega, Michael Coenen, Consuelo Lopez De Padilla, Joseph A. Panos, Alejandro Tovar, Sebastian A. Müller, Christopher H. Evans
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 2, Pp 100257- (2022)
Objective: To evaluate a single-step, gene-based procedure for repairing osteochondral lesions. Design: Osteochondral lesions were created in the patellar groove of skeletally mature rabbits. Autologous bone marrow aspirates were mixed with adenoviru
Externí odkaz:
https://doaj.org/article/b814580e853a4cd3bab7809aff52aad0
Autor:
Christopher R Paradise, Rodolfo E De La Vega, M Lizeth Galvan, Margarita E Carrasco, Roman Thaler, Andre J vanWijnen, Amel Dudakovic
Publikováno v:
JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021)
ABSTRACT Bromodomain (BRD) proteins are histone code interpreters that recognize acetylated lysines and link the dynamic state of chromatin with the transcriptional machinery. Here, we demonstrate that ablation of the Brd4 gene in primary mouse bone
Externí odkaz:
https://doaj.org/article/0f084c9fd5ba4ab08e548ed95f5d960f
Autor:
Guidong Shi, Zeling Long, Rodolfo E De la Vega, Atta Behfar, Steven L Moran, Christopher Evans, Chunfeng Zhao
Publikováno v:
Regenerative Medicine, 18(1), 55-71. Future Medicine Ltd.
Aim: This study was to detect the effects of purified exosome product (PEP) on C28/I2 cells and chondrocytes derived from osteoarthritis patients. Materials & methods: Cell viability and apoptosis assays were used to detect the effect of PEP on cells
Autor:
Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch, Aysegul Atasoy‐Zeybek, Consuelo Lopez De Padilla, Rodolfo E. De la Vega, Christopher H. Evans
Publikováno v:
Journal of Orthopaedic Research. Wiley
This study defined and compared the course of native, impaired and growth factor-stimulated bone regeneration in a rat femoral defect model. A mid-diaphyseal defect with rigid internal fixation was surgically created in the right femur of male Fische
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031255878
Delivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dc4a691b964765828bdee2b22314cd4
https://doi.org/10.1007/978-3-031-25588-5_7
https://doi.org/10.1007/978-3-031-25588-5_7
Publikováno v:
Cartilage Tissue Engineering ISBN: 9781071628386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bac97fbec91f1a761a8c78eeb05b83
https://doi.org/10.1007/978-1-0716-2839-3_20
https://doi.org/10.1007/978-1-0716-2839-3_20
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2598
Viral gene transfer, known as transduction, is a powerful research tool for studying the biology of chondrocytes in novel ways and also a technology enabling the use of gene therapy for regenerating cartilage and treating diseases that affect cartila
Autor:
Joseph A. Panos, Michael J. Coenen, Christopher V. Nagelli, Erin B. McGlinch, Aysegul Atasoy-Zeybek, Consuelo Lopez De Padilla, Ryan F. Coghlan, Brian Johnstone, Elisabeth Ferreira, Ryan M. Porter, Rodolfo E. De la Vega, Christopher H. Evans
Publikováno v:
Molecular Therapy, 31(2), 420-434. Cell Press
An estimated 100,000 patients each year in the United States suffer severe disability from bone defects that fail to heal, a con-dition where bone-regenerative therapies could provide sub-stantial clinical benefits. Although recombinant human bone mo