Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rodolfo Cadilla"'
Autor:
Helen F. Sneddon, Rodolfo Cadilla, Young Do, Jeffrey Guss, Gordon Saxty, Paresh I. Masuria, Caterina Musetti, J. Darren Stuart, Beth Pietrak, Daniela Ennulat, Andrew G. King, Barry G. Shearer, Nicholas J. Kramer, Peckham Gregory, Chuck Poole, Alan R. Rendina, Daniel J. Price, H. Fritz Kramer, Tiahshun Xu, Girish Sati, Stephen A. Thomson, Patricia A. Elkins, Jason A. Holt, Alan V. McDougal, Joseph W. Wilson, Susan B. Laffan, Michael R. Jeune, Jan Klapwijk, Dean N. Thomas, Mark Youngman, Paris Ward, Paul N. Mortenson, Lisa M. Shewchuk, Eugene L. Stewart, David N. Deaton
Publikováno v:
Bioorganicmedicinal chemistry. 28(23)
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC50 = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals. This molecule exhibited good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464fe491c8ae02c9501daac98d3f990
https://pubmed.ncbi.nlm.nih.gov/33059303
https://pubmed.ncbi.nlm.nih.gov/33059303
Autor:
Anthony L. Handlon, Lisa M. Leesnitzer, Joseph Wendell Wilson, Rodolfo Cadilla, Philip Stewart Turnbull, Chuck Poole, Raymond V. Merrihew, Lee T. Schaller, John C. Ulrich
Publikováno v:
ACS Medicinal Chemistry Letters. 7:83-88
A series of selective androgen receptor modulators (SARMs) containing the 1-(trifluoromethyl)benzyl alcohol core have been optimized for androgen receptor (AR) potency and drug-like properties. We have taken advantage of the lipophilic ligand efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1948a5cc793f5e6af8fe972330e13665
https://doi.org/10.1021/acsmedchemlett.5b00377
https://doi.org/10.1021/acsmedchemlett.5b00377
Autor:
John C. Ulrich, Petrov Kimberly, Tiffany Carpenter, David J. Cowan, J. Darren Stuart, J. David Becherer, Eugene L. Stewart, Frank Preugschat, David N. Deaton, W. Wallace Harrington, Yu Guo, Naphtali Milliken, Barry G. Shearer, Michael R. Jeune, Istvan Kaldor, Terrence L. Smalley, Curt D. Haffner, Brad R. Henke, Rodolfo Cadilla, Todd W. Shearer, Eric E. Boros, Christie Schulte
Publikováno v:
Journal of medicinal chemistry. 58(8)
A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e57c85a346e0819858a40ecdecdaa5
https://pubmed.ncbi.nlm.nih.gov/25828863
https://pubmed.ncbi.nlm.nih.gov/25828863
Publikováno v:
Current Topics in Medicinal Chemistry. 6:245-270
Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27910abb78823b837db08c179d67f11
https://doi.org/10.2174/156802606776173456
https://doi.org/10.2174/156802606776173456
Autor:
Rodolfo Cadilla, C. Fred Hassman, Stewart A. Noble, Michael Joseph Luzzio, Daniel J. Ricca, Adrian J. Pipe, Micheal D. Gaul, Kathryn L. Reed, John A. Josey, Stephen A. Thomson, Robert W. Wiethe
Publikováno v:
Tetrahedron. 51:6179-6194
The syntheses of the Fmoc-protected Peptide Nucleic Acid (PNA) monomer pentafluorophenyl esters of adenine (26), cytosine (23), guanine (29) and thymine (20), and their oligomerization are described. The Fmoc PNA backbone 1 is prepared as a stable hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f38971f2b6ea3521afedf1866aa1ba
https://doi.org/10.1016/0040-4020(95)00286-h
https://doi.org/10.1016/0040-4020(95)00286-h
Autor:
Cynthia L. Stevenson, Stewart A. Noble, Pamela H. Brown, Michael Joseph Luzzio, Stephen C. Brown, Charles W. Su, Michele A. Bonham, Daniel J. Ricca, C. Fred Hassman, Lee E. Babiss, Micheal D. Gaul, John E. Bisi, Robert W. Wiethe, Philip M. Myers, Rodolfo Cadilla, Jeffery C. Hanvey, David A. Bruckenstein, John A. Josey, Stephen A. Thomson, Adrian J. Pipe
Publikováno v:
Drug Development Research. 34:184-195
Peptide nucleic acids (PNA) are oligodeoxynucleotide (ODN) analogs in which the sugar phosphate backbone of the ODN has been replaced by one derived from units of N-ethylaminoglycine. PNAs recognize DNA and RNA in a sequence specific manner and form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4c8c13a32b936a1179593ea0369748
https://doi.org/10.1002/ddr.430340208
https://doi.org/10.1002/ddr.430340208
Autor:
Stewart A. Noble, Michael Joseph Luzzio, John A. Josey, Stephen A. Thomson, Rodolfo Cadilla, Adrian J. Pipe, C. F. Hassman, K. L. Reed, Micheal D. Gaul, Daniel J. Ricca, Robert W. Wiethe
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5c7bdaf9a7a79578111db6698c639d
https://doi.org/10.1002/chin.199538276
https://doi.org/10.1002/chin.199538276
Autor:
John A. Josey, Stephen A. Thomson, Ann Boyd, Michele A. Bonham, Lee E. Babiss, Karin G. Au, Daniel J. Ricca, Stewart A. Noble, John E. Bisi, Rodolfo Cadilla, Nancy J. Peffer, C. Fred Hassman, Jeffery C. Hanvey, David A. Bruckenstein, Stephen G. Carter
Publikováno v:
Science. 258:1481-1485
Peptide nucleic acids (PNAs) are polyamide oligomers that can strand invade duplex DNA, causing displacement of one DNA strand and formation of a D-loop. Binding of either a T10 PNA or a mixed sequence 15-mer PNA to the transcribed strand of a G-free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0800d47e69f924d08bf6ba4460b7f8
https://doi.org/10.1126/science.1279811
https://doi.org/10.1126/science.1279811
Autor:
George H. Fisher, Eugene H. Man, Radhika Chemburkar, William H. Frey, Nancy M. Garcia, Rodolfo Cadilla-Perezrios, Georgine Arends, Iris L. Payan
Publikováno v:
Journal of Neurochemistry. 48:510-515
The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c689afa2d962852b52a7b2beda1b23
https://doi.org/10.1111/j.1471-4159.1987.tb04122.x
https://doi.org/10.1111/j.1471-4159.1987.tb04122.x
Publikováno v:
Analytical Biochemistry. 149:484-491
A previously described procedure for determining the enantiomeric ratios of amino acids has produced inconsistent results when determining relatively low (less than or equal to 0.110) D/L ratios. The method involves synthesis of diastereomeric N-trif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d8ae34fe8580cff4cd9104db8d36d1
https://doi.org/10.1016/0003-2697(85)90603-7
https://doi.org/10.1016/0003-2697(85)90603-7