Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Rodolfo, Lavilla"'
Autor:
Marco Bertolini, Lorena Mendive-Tapia, Ouldouz Ghashghaei, Abigail Reese, Charles Lochenie, Anna M. Schoepf, Miquel Sintes, Karolina Tokarczyk, Zandile Nare, Andrew D. Scott, Stephen R. Knight, Advait R. Aithal, Amit Sachdeva, Rodolfo Lavilla, Marc Vendrell
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 969-977 (2024)
Externí odkaz:
https://doaj.org/article/cd2597a116b847edb6525daed38a5553
Autor:
Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield, Marc Vendrell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imag
Externí odkaz:
https://doaj.org/article/7e4b972f90a04057803fb05db7c472e8
Autor:
Angela Trejo, Carme Masdeu, Irene Serrano-Pérez, Marina Pedrola, Narcís Juanola, Ouldouz Ghashghaei, Guadalupe Jiménez-Galisteo, Rodolfo Lavilla, Francisco Palacios, Concepción Alonso, Miguel Viñas
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 83 (2023)
New antibiotic agents were prepared using Povarov and Ugi multicomponent reactions upon the known drugs sulfadoxine and dapsone. The prepared derivatives, with increased lipophilicity, showed improved efficiency against Mycolata bacteria. Microbiolog
Externí odkaz:
https://doaj.org/article/cb0cf07ddb914b668a61860981182a1d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 521-534 (2019)
Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the cas
Externí odkaz:
https://doaj.org/article/3e0ac4063b5e47a6a02325276a4ebe40
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1488 (2022)
In the context of the structural complexity necessary for a molecule to selectively display a therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic approach is essential. Typically, thousands of relatively simila
Externí odkaz:
https://doaj.org/article/a933f1a262064fb3babba3710d8795a4
Autor:
Marina Pedrola, Marta Jorba, Eda Jardas, Ferran Jardi, Ouldouz Ghashghaei, Miguel Viñas, Rodolfo Lavilla
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the
Externí odkaz:
https://doaj.org/article/9167266025804ae4bdd7b4ee6ad5556f
Autor:
Ismael Sánchez-Vera, Sonia Núñez-Vázquez, José Saura-Esteller, Ana M. Cosialls, Judith Heib, Pau Nadal Rodríguez, Ouldouz Ghashghaei, Rodolfo Lavilla, Gabriel Pons, Joan Gil, Daniel Iglesias-Serret
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8064
Fluorizoline is a synthetic molecule that induces apoptosis, by selectively targeting prohibitins (PHBs), through induction of the BH3-only protein NOXA. This induction is transcriptionally regulated by the integrated stress response (ISR)-related tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611fd67a46e5fd25be7d665c119e97a1
Autor:
Marta Jorba, Marina Pedrola, Ouldouz Ghashghaei, Rocío Herráez, Lluis Campos-Vicens, Franciso Javier Luque, Rodolfo Lavilla, Miguel Viñas
Publikováno v:
Antibiotics, Vol 10, Iss 6, p 709 (2021)
This work reports a detailed characterization of the antimicrobial profile of two trimethoprim-like molecules (compounds 1a and 1b) identified in previous studies. Both molecules displayed remarkable antimicrobial activity, particularly when combined
Externí odkaz:
https://doaj.org/article/8f05196364bf4386a24701798d921da8
Autor:
Lorena Mendive-Tapia, Can Zhao, Ahsan R. Akram, Sara Preciado, Fernando Albericio, Martin Lee, Alan Serrels, Nicola Kielland, Nick D Read, Rodolfo Lavilla, Marc Vendrell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Functionalizing antimicrobial peptides with fluorescent groups is a useful strategy for imaging infection, but the tag can alter the performance of the probe. Here, the authors report a spacer-free method to directly functionalise an amino acid with
Externí odkaz:
https://doaj.org/article/6fb748ca547d4e038602fff23bee1fb9
Publikováno v:
Synlett. 33:822-835
This Account summarizes the research of the group on the multicomponent reactions arena with fundamental heterocycles as substrates, using mechanistic considerations to hypothesize new processes and to rationalize results. Biomedical applications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b2c1b61ad87c24c28130b827c2a9a3
https://doi.org/10.1055/a-1750-3185
https://doi.org/10.1055/a-1750-3185