A Bayesian approach to incorporate structural data into the mapping of genotype to antigenic phenotype of influenza A(H3N2) viruses.

Autor: William T Harvey, Vinny Davies, Rodney S Daniels, Lynne Whittaker, Victoria Gregory, Alan J Hay, Dirk Husmeier, John W McCauley, Richard Reeve

Publikováno v: PLoS Computational Biology, Vol 19, Iss 3, p e1010885 (2023)

Surface antigens of pathogens are commonly targeted by vaccine-elicited antibodies but antigenic variability, notably in RNA viruses such as influenza, HIV and SARS-CoV-2, pose challenges for control by vaccination. For example, influenza A(H3N2) ent

Externí odkaz: https://doaj.org/article/748daf7ef66e4337b2240dde28132d5c

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.

Autor: Barbara Holzer, Pramila Rijal, Adam McNee, Basudev Paudyal, Veronica Martini, Becky Clark, Tanuja Manjegowda, Francisco J Salguero, Emily Bessell, John C Schwartz, Katy Moffat, Miriam Pedrera, Simon P Graham, Alistair Noble, Marie Bonnet-Di Placido, Roberto M La Ragione, William Mwangi, Peter Beverley, John W McCauley, Rodney S Daniels, John A Hammond, Alain R Townsend, Elma Tchilian

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009330 (2021)

Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions in both directions. The emergence of the 2009 pandemic H1N1 virus illustrates the import

Externí odkaz: https://doaj.org/article/a5cbfdb354aa4b55a29c8ce1f210c2ae

Overview of three influenza seasons in Georgia, 2014-2017.

Autor: Ann Machablishvili, Giorgi Chakhunashvili, Khatuna Zakhashvili, Irakli Karseladze, Olgha Tarkhan-Mouravi, Mari Gavashelidze, Tamar Jashiashvili, Lela Sabadze, Paata Imnadze, Rodney S Daniels, Burcu Ermetal, John W McCauley

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201207 (2018)

BACKGROUND:Influenza epidemiological and virologic data from Georgia are limited. We aimed to present Influenza Like Illness (ILI) and Severe Acute Respiratory Infection (SARI) surveillance data and characterize influenza viruses circulating in the c

Externí odkaz: https://doaj.org/article/3a275fa2baa244d0a7b773938332817c

Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses.

Autor: William T Harvey, Donald J Benton, Victoria Gregory, James P J Hall, Rodney S Daniels, Trevor Bedford, Daniel T Haydon, Alan J Hay, John W McCauley, Richard Reeve

Publikováno v: PLoS Pathogens, Vol 12, Iss 4, p e1005526 (2016)

Determining phenotype from genetic data is a fundamental challenge. Identification of emerging antigenic variants among circulating influenza viruses is critical to the vaccine virus selection process, with vaccine effectiveness maximized when consti

Externí odkaz: https://doaj.org/article/32a1f0107438412291d6245a850fac63

A Bayesian approach to incorporate structural data into the mapping of genotype to antigenic phenotype of influenza A(H3N2) viruses

Autor: William T. Harvey, Vinny Davies, Rodney S. Daniels, Lynne Whittaker, Victoria Gregory, Alan J. Hay, Dirk Husmeier, John W. McCauley, Richard Reeve

Publikováno v: Harvey, W, Davies, V, Daniels, R S, Whittaker, L, Gregory, V, Hay, A J, Husmeier, D, McCauley, J W & Reeve, R 2023, ' A Bayesian approach to incorporate structural data into the mapping of genotype to antigenic phenotype of influenza A(H3N2) viruses ', PLoS Computational Biology, vol. 19, no. 3, e1010885, pp. 1-28 . https://doi.org/10.1371/journal.pcbi.1010885

Surface antigens of pathogens are commonly targeted by vaccine-elicited antibodies but antigenic variability, notably in RNA viruses such as influenza, HIV and SARS-CoV-2, pose challenges for control by vaccination. For example, influenza A(H3N2) ent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0047c451743d3bf3b886a5d73af3f55